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Development of a liver rehabilitation program for practical application of a remote diet and exercise program

Research Project

Project/Area Number 18K17918
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

OH SECHANG  筑波大学, 医学医療系, 研究員 (10789639)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords振動刺激 / 加速度訓練 / 運動 / 遠隔指導 / マイオカイン / 糖代謝 / 疲労 / 生活習慣病 / 筋硬度 / 運動療法 / 遠隔運動指導 / 全身振動プログラム / 脂肪肝 / 非アルコール性脂肪性肝疾患 / 食事療法 / 身体組成 / Titin-N fragment / 慢性腰痛症 / 全身振動トレーニング / アディポカイン / ヘパトカイン / 肥満 / 食事
Outline of Final Research Achievements

This study aimed to develop a practical remote exercise program that can be used as a more proactive support measure for a large number of patients in a medical organization. Although exercise is essential as a primary treatment, many patients have difficulty practicing and continuing exercise due to psychological and physical obstacles and susceptibility to fatigue. Therefore, we devised a vibration program consisting of movements that efficiently stimulate skeletal muscles throughout the body in a short time. Implementation of this program revealed improvement in glucose and lipid metabolism along with improvement in myokines. The results suggest that this program is an effective exercise method with excellent continuity and efficiency, even for those who tend to avoid exercise, and does not cause a high degree of fatigue. Furthermore, this program can be used without difficulty in remote exercise programs.

Academic Significance and Societal Importance of the Research Achievements

生活習慣病に対して運動療法は基本治療として重要であるが、心理的・身体的な障害や疲労しやすい点より、運動療法の実践と継続が困難である症例も少なくない。そこで,娯楽性・安全性・継続性に優れ,効果的な運動療法の代替手段の確立が求められている。本研究の最初ステップとして、日常の運動が困難な者でも楽しく実施可能な「適切かつ誰でも続けられる運動療法」をコンセプトに、遠隔運動指導で無理なく十分使える新たな運動法の構築を目指した。本プログラムは運動実践に苦しむ多くの人へ遠隔的に適用することが可能であり、身体的自立やその親族の介護負担の軽減を通じて、生涯自立と生きがいを確保する点で大きな意義があると考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019 2018

All Journal Article (15 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 14 results,  Open Access: 15 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] The anthropometric measure ‘A Body Shape Index' may predict the risk of osteoporosis in middle-aged and older Korean people2022

    • Author(s)
      Bokun Kim, Gwon-Min Kim, Eonho Kim, Joonsung Park, Tomonori Isobe, Yutaro Mori, Sechang Oh
    • Journal Title

      Int J Environ Res Public Health

      Volume: 19 Issue: 8 Pages: 4926-4926

    • DOI

      10.3390/ijerph19084926

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice2021

    • Author(s)
      Miura I, Komine S, Okada K, Wada S, Warabi E, Uchida F, Oh S, Suzuki H, Mizokami Y, Shoda J
    • Journal Title

      Physiol Reps

      Volume: 9 Issue: 9

    • DOI

      10.14814/phy2.14859

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of dietary habits and physical activity levels with non-alcoholic fatty liver disease with advanced liver fibrosis2021

    • Author(s)
      Yabe Y, Kim T, Oh S, Oshida N, Hasegawa N, Kamimaki T, Someya N, Shoda J
    • Journal Title

      Int J Environ Res and Public Health

      Volume: 18 Issue: 17 Pages: 8918-8918

    • DOI

      10.3390/ijerph18178918

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise in young adults: A pilot study2021

    • Author(s)
      Komine S, Miura I, Shoda J, TokinoyaK, Oh S, Miyashita N, Omori H
    • Journal Title

      Physiol Reps

      Volume: 9 Issue: 24 Pages: 15130-15130

    • DOI

      10.14814/phy2.15130

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The A Body Shape Index Might Be a Stronger Predictor of Chronic Kidney Disease Than BMI in a Senior Population2021

    • Author(s)
      Kim Bokun、Kim Gwonmin、Kim Eonho、Park Jonghwan、Isobe Tomonori、Sakae Takeji、Oh Sechang
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 24 Pages: 12874-12874

    • DOI

      10.3390/ijerph182412874

    • Related Report
      2021 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Establishment of a murine, lipopolysaccharide-induced sepsis model for testing anaerobic exercise thresholds and early mobilization2021

    • Author(s)
      Matsuishi Yujiro、Shimojo Nobutake、Hoshino Haruhiko、Enomoto Yuki、Mathis Bryan J.、Oh Sechang、Kawano Satoru、Myoenzono Kanae、Maeda Seiji、Shoda Junichi、Inoue Shigeaki、Inoue Yoshiaki
    • Journal Title

      Medicine in Drug Discovery

      Volume: 9 Pages: 100074-100074

    • DOI

      10.1016/j.medidd.2020.100074

    • URL

      https://pure.teikyo.jp/en/publications/8e313d46-fd94-4c8b-a1a0-fb7f05e0e852

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD2021

    • Author(s)
      Oh Sechang、Tsujimoto Takehiko、Kim Bokun、Uchida Fumihiko、Suzuki Hideo、Iizumi Seiichiro、Isobe Tomonori、Sakae Takeji、Tanaka Kiyoji、Shoda Junichi
    • Journal Title

      JHEP Reports

      Volume: 3 Issue: 3 Pages: 100253-100253

    • DOI

      10.1016/j.jhepr.2021.100253

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Exercise on the Oral Microbiota and Saliva of Patients with Non-Alcoholic Fatty Liver Disease2021

    • Author(s)
      Uchida F, Oh S, Shida T, Suzuki H, Yamagata K, Mizokami Y, Bukawa H, Tanaka K, Shoda J
    • Journal Title

      Int J Environ Res Public Health

      Volume: 18 Issue: 7 Pages: 3470-3470

    • DOI

      10.3390/ijerph18073470

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical and anthropometric characteristics of non‐obese non‐alcoholic fatty liver disease subjects in Japan2020

    • Author(s)
      Shida Takashi、Oshida Natsumi、Suzuki Hideo、Okada Kosuke、Watahiki Takahisa、Oh Sechang、Kim Taeho、Isobe Tomonori、Okamoto Yoshikazu、Ariizumi Shun‐ichi、Yamamoto Masakazu、Shoda Junichi
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 9 Pages: 1032-1046

    • DOI

      10.1111/hepr.13543

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiorespiratory fitness is strongly linked to metabolic syndrome among physical fitness components: a retrospective cross-sectional study2020

    • Author(s)
      Kim Bokun、Ku Minjae、Kiyoji Tanaka、Isobe Tomonori、Sakae Takeji、Oh Sechang
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 39 Issue: 1 Pages: 30-30

    • DOI

      10.1186/s40101-020-00241-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships of Fat and Muscle Mass with Chronic Kidney Disease in Older Adults: A Cross-Sectional Pilot Study2020

    • Author(s)
      Kim Bokun、Park Hyuntae、Kim Gwonmin、Isobe Tomonori、Sakae Takeji、Oh Sechang
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 23 Pages: 9124-9124

    • DOI

      10.3390/ijerph17239124

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary Levels of Titin-N Fragment, a Skeletal Muscle Damage Marker, are Increased in Subjects with Nonalcoholic Fatty Liver Disease2019

    • Author(s)
      Oshida Natsumi、Shida Takashi、Oh Sechang、Kim Taeho、Isobe Tomonori、Okamoto Yoshikazu、Kamimaki Takashi、Okada Kosuke、Suzuki Hideo、Ariizumi Shun-ichi、Yamamoto Masakazu、Shoda Junichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19498-19498

    • DOI

      10.1038/s41598-019-56121-7

    • NAID

      120007132916

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole body vibration for patients with nonalcoholic fatty liver disease: a 6-month prospective study2019

    • Author(s)
      Oh S, Oshida N, Someya N, Maruyama T, Isobe T, Okamoto Y, Kim T, Kim B, Shoda J
    • Journal Title

      Physiological Reports

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Progressive reduction in skeletal muscle mass to visceral fat area ratio is associated with a worsening of the hepatic conditions of non-alcoholic fatty liver disease2019

    • Author(s)
      Shida T, Oshida N, Oh S, Okada K, Shoda J
    • Journal Title

      Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

      Volume: 12 Pages: 495-503

    • DOI

      10.2147/dmso.s185705

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abdominal fat accumulation as a potential risk factor for low back pain in adult men: a comparative study2019

    • Author(s)
      Kim B, Oh S, Ku M, Kim E
    • Journal Title

      International Journal of Applied Exercise Physiology

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 中高年肥満者における全身振動プログラムが糖代謝能と疲労度に及ぼす影響2021

    • Author(s)
      張翰林、金美珍、金泰浩、磯辺智範、森祐太郎、栄武二、大藏倫博、田中喜代次、 呉世昶
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヒト遅発性筋痛の抑制に及ぼすスルフォラファン摂取の有効性2021

    • Author(s)
      上野友睦、三浦往、小峰昇一、時野谷勝幸、呉世昶、羅成圭、石倉恵介、胡騰、大森肇
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 水素水による抗酸化能の増大が運動耐容能に与える影響2021

    • Author(s)
      高倉有,西野遼,平野伸一,早川瑠璃子,呉世昶,森祐太郎,磯辺智範,榮武二
    • Organizer
      第28回日本運動生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における食生活パターンの調査2020

    • Author(s)
      矢部義人,志田隆史,金泰浩,呉世昶,正田純一
    • Organizer
      第56回日本肝臓学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Anti-steatosis and fibrosis effect is a weight loss-independent benefit of regular exercise on NAFLD: a retrospective study2020

    • Author(s)
      Sechang Oh, Bokun Kim, Tomonori Isobe, Takeji Sakae, Junichi Shoda
    • Organizer
      2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular hydrogen improves exercise endurance capacity in mice2020

    • Author(s)
      Yu Takakura, Ryo Nishino, Ruriko Hayakawa, Sechang Oh, Takeji Sakae, Ikuru Miura, Junichi Shoda, Tomonori Isobe
    • Organizer
      2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Decreased cardiorespiratory fitness is strongly associated with metabolic syndrome: A cross-sectional study2020

    • Author(s)
      Bokun Kim, Sechang Oh, Tomonori Isobe, Takeji Sakae
    • Organizer
      2020 International Congress on Obesity and Metabolic Syndrome (ICOMES) meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有酸素性運動は転写因子Nrf2活性化を誘導し非アルコール性脂肪性肝疾患(NAFLD)の肝病態を改善する2019

    • Author(s)
      呉世昶,正田純一
    • Organizer
      第27回日本消化器関連学会週間
    • Related Report
      2019 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)における体重減少とは独立した運動療法の肝病態改善効果2019

    • Author(s)
      呉世昶,田中喜代次,正田純一
    • Organizer
      第74回日本体力医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 継続的走運動は高脂肪食摂餌 p62 遺伝子欠失マウスにおける脂肪性肝炎を改善する2019

    • Author(s)
      和田聖大,小峰昇一,岡田浩介,呉 世昶,蕨 栄治,大森肇,正田純一
    • Organizer
      第27回日本消化器関連学会週間
    • Related Report
      2019 Research-status Report
  • [Presentation] NAFLDの運動療法による病態改善効果とヘパトカイン,マイオカイン,アディポカインの変動2018

    • Author(s)
      呉 世昶,正田純一
    • Organizer
      第42回日本肝臓学会東部会(パネルディスカッション NASH・NAFLD の展望)
    • Related Report
      2018 Research-status Report
  • [Presentation] Role of exercise in weight loss and weight maintenance2018

    • Author(s)
      Oh S, Kim J, Shoda J
    • Organizer
      2018 Spring Scientific Meeting of KSSO
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂肪肝の改善に向けた運動療法の重要性2018

    • Author(s)
      呉 世昶
    • Organizer
      第9回市民公開講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 医師・コメディカルのための メディカルフィットネス2019

    • Author(s)
      日本体力医学会(日本医学会第39分科会);呉世昶
    • Total Pages
      160
    • Publisher
      社会保険研究所
    • ISBN
      9784789468206
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2025-03-27  

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