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Functional dietary lipids and gut microbiota on metabolic disorders

Research Project

Project/Area Number 18K17920
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Miyamoto Junki  東京農工大学, (連合)農学研究科(研究院), 准教授 (20805668)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords腸内細菌 / 腸内細菌代謝物 / 食用油 / 肥満 / エネルギー代謝 / 内分泌 / GLP-1 / gut microbial metabolite / gut microbiota / FFARs / obesity / dietary lipid / GPCRs / free fatty acid receptor / 脂肪酸受容体
Outline of Final Research Achievements

The present study provided that gut microbial metabolites derived from dietary lipids prevent high fat diet-induced obesity. Gut microbial metabolites contribute to promoting the secretion of GLP-1 via GPR40/GPR120 in enteroendocrine cells and regulate glucose homeostasis. These findings suggest that gut microbial metabolites derived from dietary lipids could contribute to the development of novel therapeutic strategies for metabolic disorders.

Academic Significance and Societal Importance of the Research Achievements

近年の腸内細菌研究の発展に伴い、様々な病態と密接に関与することが科学的根拠に基づいて明らかにされ始めている。本研究における食用油-腸内環境-生体側の受容体を介した生体エネルギー代謝調節の解明は、新たな代謝性疾患における治療標的となる可能性が示唆される。今後、機能性食用油の摂取、プロバイオティクス様の腸内細菌代謝産生菌の投与、さらには、腸内細菌代謝物の直接的な摂取による代謝性疾患に対する新たな治療法の開発が期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (54 results)

All 2021 2020 2019 2018 Other

All Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 12 results,  Open Access: 11 results) Presentation (23 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Book (16 results) Remarks (3 results)

  • [Journal Article] Gut microbial short-chain fatty acids-mediated olfactory receptor 78 stimulation promotes anorexigenic gut hormone peptide YY secretion in mice.2021

    • Author(s)
      Nishida A, Miyamoto J, Shimizu H, Kimura I.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 557 Pages: 48-54

    • DOI

      10.1016/j.bbrc.2021.03.167

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia2021

    • Author(s)
      Lee Eunyoung、Zhang Xilin、Noda Tomoe、Miyamoto Junki、Kimura Ikuo、Tanaka Tomoaki、Sakurai Kenichi、Hatano Ryo、Miki Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 19 Pages: 10796-10796

    • DOI

      10.3390/ijms221910796

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice2020

    • Author(s)
      Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
    • Journal Title

      Science

      Volume: 367 Issue: 6481 Pages: 8429-8429

    • DOI

      10.1126/science.aaw8429

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of uremic dysbiosis to insulin resistance and sarcopenia.2020

    • Author(s)
      Uchiyama K, Wakino S, Irie J, Miyamoto J, Matsui A, Tajima T, Itoh T, Oshima Y, Yoshifuji A, Kimura I, Itoh H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 35 Issue: 9 Pages: 1501-1517

    • DOI

      10.1093/ndt/gfaa076

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice.2019

    • Author(s)
      Ohue-Kitano R, Taira S, Watanabe K, Masujima Y, Kuboshima T, Miyamoto J, Nishitani Y, Kawakami H, Kuwahara H, Kimura I.
    • Journal Title

      Nutrients.

      Volume: 11 Issue: 5 Pages: 1036-1036

    • DOI

      10.3390/nu11051036

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids2019

    • Author(s)
      Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41467-019-11978-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms2019

    • Author(s)
      Lee Eunyoung、Miedzybrodzka Emily L.、Zhang Xilin、Hatano Ryo、Miyamoto Junki、Kimura Ikuo、Fujimoto Kosuke、Uematsu Satoshi、Rodriguez-Cuenca Sergio、Vidal-Puig Antonio、Gribble Fiona M.、Reimann Frank、Miki Takashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 18 Pages: 4448-4448

    • DOI

      10.3390/ijms20184448

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions2019

    • Author(s)
      Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 116 Issue: 47 Pages: 23813-23821

    • DOI

      10.1073/pnas.1912573116

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway2018

    • Author(s)
      Lee Eun-Young、Zhang Xilin、Miyamoto Junki、Kimura Ikuo、Taknaka Tomoaki、Furusawa Kenichi、Jomori Takahito、Fujimoto Kosuke、Uematsu Satoshi、Miki Takashi
    • Journal Title

      Journal of Endocrinology

      Volume: 239 Issue: 3 Pages: 267-276

    • DOI

      10.1530/joe-18-0241

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.2018

    • Author(s)
      Watanabe K, Igarashi M, Li X, Nakatani A, Miyamoto J, Inaba Y, Sutou A, Saito T, Sato T, Tachibana N, Inoue H, Kimura I.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 8 Pages: e0202083-e0202083

    • DOI

      10.1371/journal.pone.0202083

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner.2018

    • Author(s)
      Nakatani A, Li X, Miyamoto J, Igarashi J, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H, Kimura I.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 501 Issue: 4 Pages: 955-961

    • DOI

      10.1016/j.bbrc.2018.05.090

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Barley β-glucan improves metabolic condition via short-chain fatty acids produced by gut microbial fermentation in high fat diet fed mice.2018

    • Author(s)
      Miyamoto J, Watanabe K, Taira S, Kasubuchi M, Li X, Irie J, Itoh H, Kimura I.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 4 Pages: e0196579-e0196579

    • DOI

      10.1371/journal.pone.0196579

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規短鎖脂肪酸受容体 Olfr78 を介した代謝調節機構の解明2021

    • Author(s)
      西田朱里、宮本潤基、清水秀憲、木村郁夫
    • Organizer
      内分泌代謝学サマーセミナー
    • Related Report
      2021 Annual Research Report
  • [Presentation] 母胎連関における食由来代謝物と生体エネルギー代謝調節2021

    • Author(s)
      安藤有菜、宮本潤基、木村郁夫
    • Organizer
      内分泌代謝学サマーセミナー
    • Related Report
      2021 Annual Research Report
  • [Presentation] 食由来腸内細菌代謝物の脂肪酸受容体を介したエネルギー代謝調節2021

    • Author(s)
      宮本潤基、入江潤一郎、伊藤裕、木村郁夫
    • Organizer
      第42回日本肥満学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Metabolic regulation via ketone body receptors under ketogenic conditions2021

    • Author(s)
      Nishida Akari, Junki Miyamoto, Ryuji Ohue-Kitano, Hironori Katoh, Ikuo Kimura
    • Organizer
      Experimental Biology 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食・栄養シグナルの分子レベルでの解明;栄養シグナルとしての脂肪酸の利用2021

    • Author(s)
      宮本潤基
    • Organizer
      Visionary農芸化学100 symposium(食品機能学領域)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 脂肪酸受容体とエネルギー代謝調節2021

    • Author(s)
      宮本潤基、木村郁夫
    • Organizer
      第37回DDS学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 食由来腸内細菌代謝物と肥満2021

    • Author(s)
      宮本潤基
    • Organizer
      第39回日本内分泌学会 内分泌代謝学サマーセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 創薬応用に向けた栄養認識受容体と肥満2021

    • Author(s)
      宮本潤基、木村郁夫
    • Organizer
      日本薬理学会次世代の会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 食事脂質由来腸内細菌代謝産物と宿主エネルギー代謝制御2020

    • Author(s)
      向山広美、宮本潤基、五十嵐美樹、木村郁夫
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ケトジェニック環境下におけるGPR109Aの機能解析2020

    • Author(s)
      西田朱里、大植隆司、宮本潤基、木村郁夫
    • Organizer
      日本栄養食糧学会第74回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] GPCRs for ketone bodies and energy homeostasis2020

    • Author(s)
      宮本潤基
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 食由来栄養シグナルと宿主エネルギー代謝調節2020

    • Author(s)
      宮本潤基
    • Organizer
      第51回HiHA Webinar
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 食由来腸内細菌代謝物とエネルギー制御2020

    • Author(s)
      宮本潤基、木村郁夫
    • Organizer
      第9回Academy of Aging and CArdiovascular-Diabetes Research研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 食由来腸内細菌代謝物と肥満2020

    • Author(s)
      宮本潤基
    • Organizer
      第41回日本肥満学会・第38回日本肥満症治療学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Host energy regulation by gut microbial metabolites derived from ω6 polyunsaturated fatty acids.2019

    • Author(s)
      Miyamoto J, Igarashi M, Sugimoto Y, Arita M, Kimura I
    • Organizer
      60th International Conference on the Bioscience of Lipids (ICBL2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.2019

    • Author(s)
      Miyamoto J, Mukouyama H, Kimura I
    • Organizer
      Winter conference 2019: Diet and Digestive disease
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 腸内環境と栄養シグナルによる宿主エネルギー代謝制御機構の解明2019

    • Author(s)
      宮本潤基、北野(大植)隆司、五十嵐美樹、入江潤一郎、伊藤裕、木村郁夫
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ケトジェニック環境下におけるGPR43の機能解析2019

    • Author(s)
      宮本潤基、北野(大植)隆司、五十嵐美樹、入江潤一郎、伊藤裕、木村郁夫
    • Organizer
      第19回日本抗加齢医学会総会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食由来栄養シグナルと腸内環境を介した宿主エネルギー代謝制御2019

    • Author(s)
      宮本潤基、木村郁夫
    • Organizer
      生理学研究所研究会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食事脂質由来腸内細菌代謝物と宿主生体恒常性維持2018

    • Author(s)
      宮本潤基、木村郁夫
    • Organizer
      第9回機能油脂懇話会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Gut microbiota and free fatty acid receptors mediated host energy regulation2018

    • Author(s)
      Miyamoto Junki, Kimura Ikuo
    • Organizer
      AOCS Annual Meeting & Expo
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 腸内細菌代謝物と腸管バリア2018

    • Author(s)
      宮本潤基、鈴木卓弥、木村郁夫、田辺創一
    • Organizer
      第22回日本心血管内分泌代謝学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脂肪酸受容体を介した腸内細菌代謝物の包括的なエネルギー代謝制御機構の解明2018

    • Author(s)
      宮本潤基、唐木晋一郎、岸野重信、入江潤一郎、菅原達也、杉本幸彦、有田誠、小川順、伊藤裕、木村郁夫
    • Organizer
      第91回日本内分泌学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] ケトン体(アセト酢酸)の受容体を介した脂質代謝2021

    • Author(s)
      西田朱里、宮本潤基、木村郁夫
    • Total Pages
      3
    • Publisher
      化学と生物
    • Related Report
      2021 Annual Research Report
  • [Book] 妊娠中の食物繊維摂取と胎児の代謝2021

    • Author(s)
      渡辺啓太、西田朱里、宮本潤基、木村郁夫
    • Total Pages
      9
    • Publisher
      糖尿病学2021
    • Related Report
      2021 Annual Research Report
  • [Book] 腸内環境と肥満2021

    • Author(s)
      宮本潤基、木村郁夫
    • Total Pages
      4
    • Publisher
      Medical Practice.
    • Related Report
      2021 Annual Research Report
  • [Book] 食と腸内細菌による宿主の代謝制御2021

    • Author(s)
      宮本潤基、渡辺啓太、木村郁夫
    • Total Pages
      186
    • Publisher
      生化学
    • Related Report
      2020 Research-status Report
  • [Book] ケトン体生成を促す食事療法による体脂肪減少メカニズム2020

    • Author(s)
      渡辺啓太、向山広美、宮本潤基、木村郁夫
    • Total Pages
      287
    • Publisher
      バイオサイエンスとインダストリー(B&I)
    • Related Report
      2020 Research-status Report
  • [Book] 腸内細菌叢と肥満(脂質)2020

    • Author(s)
      向山広美、宮本潤基、木村郁夫
    • Total Pages
      624
    • Publisher
      ヒトマイクロバイオーム最前線
    • Related Report
      2020 Research-status Report
  • [Book] 食由来栄養シグナルと腸内環境を介した宿主エネルギー代謝制御2020

    • Author(s)
      渡辺啓太、向山広美、宮本潤基、木村郁夫
    • Total Pages
      78
    • Publisher
      糖尿病・内分泌代謝科
    • Related Report
      2020 Research-status Report
  • [Book] 妊娠中の母体の代謝がこどもに与える影響2020

    • Author(s)
      宮本潤基、渡辺啓太、木村郁夫、長谷耕二
    • Total Pages
      123
    • Publisher
      臨床免疫・アレルギー科
    • Related Report
      2020 Research-status Report
  • [Book] 腸内細菌とDOHaD学説2020

    • Author(s)
      宮本潤基、渡辺啓太、木村郁夫
    • Total Pages
      116
    • Publisher
      Pharma Medica
    • Related Report
      2020 Research-status Report
  • [Book] 胎児期・乳児期の腸内細菌叢の長期的影響2020

    • Author(s)
      渡辺啓太、宮本潤基、長谷耕二、木村郁夫
    • Total Pages
      70
    • Publisher
      医学のあゆみ 特集号
    • Related Report
      2020 Research-status Report
  • [Book] 低炭水化物食における分子栄養メカニズム2020

    • Author(s)
      西田朱里、宮本潤基、大植隆司、木村郁夫
    • Total Pages
      89
    • Publisher
      Pharma Medica
    • Related Report
      2020 Research-status Report
  • [Book] 宿主エネルギー代謝制御における腸内細菌と遊離脂肪酸の役割2019

    • Author(s)
      向山広美, 宮本潤基
    • Total Pages
      6
    • Publisher
      オレオサイエンス
    • Related Report
      2019 Research-status Report
  • [Book] 短鎖脂肪酸による疾患制御2019

    • Author(s)
      宮本潤基, 木村郁夫
    • Total Pages
      5
    • Publisher
      医学のあゆみ 特集号
    • Related Report
      2019 Research-status Report
  • [Book] 腸内細菌叢を標的にした医薬品と保健機能食品の開発2018

    • Author(s)
      宮本潤基、木村郁夫
    • Total Pages
      8
    • Publisher
      技術情報協会
    • Related Report
      2018 Research-status Report
  • [Book] 脂肪酸代謝と腸内環境2018

    • Author(s)
      宮本潤基、中谷明穂、木村郁夫
    • Total Pages
      6
    • Publisher
      アンチ・エイジング医学
    • Related Report
      2018 Research-status Report
  • [Book] 肥満と腸内細菌叢2018

    • Author(s)
      渡辺啓太、宮本潤基、木村郁夫
    • Total Pages
      4
    • Publisher
      Modern Physician.
    • Related Report
      2018 Research-status Report
  • [Remarks] 妊娠中の食物繊維摂取は胎児の代謝機能の発達を促し、出生後、子の肥満になりにくい体質をつくる

    • URL

      https://www.tuat.ac.jp/outline/disclosure/pressrelease/2019/20200226_01.html

    • Related Report
      2020 Research-status Report
  • [Remarks] 腸内細菌は食用油に含まれる多価不飽和脂肪酸を代謝することにより宿主の肥満を防ぐことを解明

    • URL

      https://www.tuat.ac.jp/outline/disclosure/pressrelease/2019/20190905_01.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 低炭水化物食や断続的断食による減量メカニズムの解明―ケトン体の新たな受容体を発見―

    • URL

      https://www.tuat.ac.jp/outline/disclosure/pressrelease/2019/20191101_01.html

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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