Implication of alpha-Klotho as a novel predictor of stress

• Project/Area Number: 18K17923
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Osaka University
• Principal Investigator: Nakanishi Kaori 大阪大学, キャンパスライフ健康支援センター, 助教 (10650872)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ストレス / 健康障害 / Klotho / バイオマーカー / クロトー

Outline of Final Research Achievements

While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of αKlotho as a possible objective biomarker of stress. Serum levels of soluble αKlotho (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the sαKl levels. Since sαKl showed the same tendency as the total Kessler Screening Scale for Psychological Distress (K6) score in terms of the relationship between stress management and sleeping conditions, increased sαKl levels could be associated with considerable psychological stress.
We also evaluated the role of sαKl in preventing disease progression. A decrease in sαKl levels could be associated with the progression of pre-clinical disorders.

Academic Significance and Societal Importance of the Research Achievements

慢性的なストレスはメンタルの不調だけでなく心血管疾患、消化器疾患、メタボリックシンドロームなど様々な疾患や健康障害を増悪させ、現代社会において大きな問題となっており、ストレスへの対策は疾病予防の観点からも極めて重要である。しかし、今までストレスを客観的に評価する確立された指標は明らかにはなっていなかった。本研究で、ストレスや睡眠の質が血中の老化関連分子クロトーに影響を与えることを発見したことから、ストレス状態を示す新しいバイオマーカーとして、血清αKlothoが今後利用できる可能性があると考えられる。

Research Products

• [Journal Article] Serum Klotho Levels Contribute to the Prevention of Disease Progression. (2021)
  • Author(s): Nakanishi K, Nishida M, Taneike M, Yamamoto R, Moriyama T, Yamauchi-Takihara K.
  • Journal Title: Int J Gen Med. Volume: 14 Pages: 229-236
  • DOI: 10.2147/ijgm.s291437
  • Peer Reviewed / Open Access
• [Journal Article] Alpha-Klotho is a novel predictor of treatment responsiveness in patients with heart failure. (2021)
  • Author(s): Taneike M, Nishida M, Nakanishi K, Sera F, Kioka H, Yamamoto R, Ohtani T, Hikoso S, Moriyama T, Sakata Y, Yamauchi-Takihara K.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 2058-2058
  • DOI: 10.1038/s41598-021-81517-9
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Skipping Breakfast, Lunch, and Dinner with Weight Gain and Overweight/Obesity in University Students: A Retrospective Cohort Study (2021)
  • Author(s): Yamamoto Ryohei、Tomi Ryohei、Shinzawa Maki、Yoshimura Ryuichi、Ozaki Shingo、Nakanishi Kaori、Ide Seiko、Nagatomo Izumi、Nishida Makoto、Yamauchi-Takihara Keiko、Kudo Takashi、Moriyama Toshiki
  • Journal Title: Nutrients Volume: 13 Issue: 1 Pages: 271-271
  • DOI: 10.3390/nu13010271
  • Peer Reviewed / Open Access
• [Journal Article] Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. (2021)
  • Author(s): Koba, Takeda, Narumi, Shiromizu, Nojima, Ito, Kuroyama, Futami, Takimoto, Matsuki, Edahiro, Nojima, Hayama, Fukushima, Hirata, Koyama, Iwahori, Nagatomo, Suzuki, Shirai, Murakami, Nakanishi, Nakatani, Suga, Miyake, Shiroyama, Kida, Sasaki, Ueda, Mizuguchi, Adachi, Tomonaga, Kumanogoh
  • Journal Title: ERJ open research. Volume: 7(1) Issue: 1 Pages: 00658-2020
  • DOI: 10.1183/23120541.00658-2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study (2020)
  • Author(s): Tomi Ryohei、Yamamoto Ryohei、Shinzawa Maki、Kimura Yoshiki、Fujii Yoshiyuki、Aoki Katsunori、Ozaki Shingo、Yoshimura Ryuichi、Taneike Manabu、Nakanishi Kaori、Nishida Makoto、Yamauchi-Takihara Keiko、Kudo Takashi、Isaka Yoshitaka、Moriyama Toshiki
  • Journal Title: Nutrients Volume: 12 Issue: 11 Pages: 3549-3549
  • DOI: 10.3390/nu12113549
  • Peer Reviewed / Open Access
• [Journal Article] Occupational sedentary behavior and prediction of proteinuria in young to middle-aged adults: a retrospective cohort study (2020)
  • Author(s): Fujii Yoshiyuki、Yamamoto Ryohei、Shinzawa Maki、Kimura Yoshiki、Aoki Katsunori、Tomi Ryohei、Ozaki Shingo、Yoshimura Ryuichi、Taneike Manabu、Nakanishi Kaori、Nishida Makoto、Yamauchi-Takihara Keiko、Kudo Takashi、Isaka Yoshitaka、Moriyama Toshiki
  • Journal Title: Journal of Nephrology Volume: 27 Issue: 3 Pages: 719-728
  • DOI: 10.1007/s40620-020-00826-w
  • Peer Reviewed
• [Journal Article] An Implication of alpha-Klotho as the Predictive Factor of Stress: A Cross-sectional Study (2019)
  • Author(s): Kaori Nakanishi, Makoto Nishida, Manabu Taneike, Ryohei Yamamoto, Hiroyoshi Adachi, Toshiki Moriyama, Keiko Yamauchi-Takihara
  • Journal Title: Journal of Investigative Medicine Volume: 印刷中 Issue: 7 Pages: 1082-1086
  • DOI: 10.1136/jim-2018-000977
  • Peer Reviewed
• [Remarks] 大阪大学キャンパスライフ健康支援センターホームページ
  • URL: https://hacc.osaka-u.ac.jp/ja/
• [Remarks] ResOU（リソウ）
  • URL: https://resou.osaka-u.ac.jp/ja