Does Morning or Evening Exercise Alter HDL cholesterol efflux capacity and Clock Gene Expression?

• Project/Area Number: 18K17940
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Waseda University
• Principal Investigator: Kim Hyeon Ki 早稲田大学, 理工学術院, 講師(任期付) (10791874)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 運動実施時間帯 / 血中脂質 / HDL-C取り込み能 / 日内リズム / 血糖値 / HDL-C引き抜き能 / 時計遺伝子

Outline of Final Research Achievements

The purpose of this study was to examine the effects of short-term (1 week) morning or evening endurance exercise on HDL-cholesterol efflux capacity (a measure of the function of good cholesterol) and blood lipids in healthy young men. The results showed that HDL-C and TG/HDL ratios increased and decreased significantly after the intervention compared to baseline in both trials. On the other hand, triglyceride and apolipoprotein B concentrations were significantly decreased only in the evening trial compared to the morning trial. However, there was no significant change in HDL-cholesterol efflux capacity in both trials.
These results suggest that evening endurance exercise may have a more favorable effect on cardiovascular disease risk factors than morning endurance exercise.

Academic Significance and Societal Importance of the Research Achievements

本研究は、異なる運動実施時間帯（朝・夕）から新たな心血管疾患の予測因子（HDL-C引き抜き能）及び血中脂質（HDL-C、LDL-C）に着目し、それを活かした持久性運動の効果を検討した。その結果、夕の持久性運動は、朝の持久性運動に比べて心血管疾患リスク因子により好ましい影響を与える可能性が示唆された。本研究の主な知見は、心血管疾患を予防させる上で、現場での指導に直接利用できる有益な情報をもたらすといえる。また、様々な病態や疾患との関連性についても示唆できる可能性があり、研究の更なる発展性が期待できる。

Research Products

• [Journal Article] Consumption of Biscuits with a Beverage of Mulberry or Barley Leaves in the Afternoon Prevents Dinner-Induced High, but Not Low, Increases in Blood Glucose among Young Adults (2020)
  • Author(s): Kuwahara Mai、Kim Hyeon-Ki、Ozaki Mamiho、Nanba Takuya、Chijiki Hanako、Fukazawa Mayuko、Okubo Jin、Mineshita Yui、Takahashi Masaki、Shibata Shigenobu
  • Journal Title: Nutrients Volume: 12 Issue: 6 Pages: 1580-1580
  • DOI: 10.3390/nu12061580
  • Peer Reviewed
• [Journal Article] Effect of the Intake of a Snack Containing Dietary Fiber on Postprandial Glucose Levels (2020)
  • Author(s): Kim HK, Nanba T, Ozaki M, Chijiki H, Takahashi M, Fukazawa M, Okubo J, Shibata S.
  • Journal Title: Foods Volume: 9 Issue: 10 Pages: 1500-1500
  • DOI: 10.3390/foods9101500
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans. (2020)
  • Author(s): Masaki Takahashi, Mamiho Ozaki, Miku Tsubosaka, Hyeon-Ki Kim, Hiroyuki Sasaki, Yuji Matsui, Masanobu Hibi, Noriko Osaki, Masashi Miyashita, Shigenobu Shibata
  • Journal Title: Nutrients Volume: 12 Issue: 2 Pages: 565-565
  • DOI: 10.3390/nu12020565
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chrono-exercise for health promotion (2019)
  • Author(s): Hyeon-Ki Kim
  • Journal Title: Korean Journal of human movement Volume: 1 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Effects of increased daily physical activity on mental health and depression biomarkers in postmenopausal women (2019)
  • Author(s): Takahashi M, Lim PJ, Tsubosaka M, Kim H-K, Miyashita M, Suzuki K, Tan EL, Shibata S
  • Journal Title: Journal of Physical Therapy Science Volume: 31 Issue: 4 Pages: 408-413
  • DOI: 10.1589/jpts.31.408
  • NAID: 130007621862
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults (2018)
  • Author(s): Takahashi Masaki、Ozaki Mamiho、Kang Moon-Il、Sasaki Hiroyuki、Fukazawa Mayuko、Iwakami Tamao、Lim Pei、Kim Hyeon-Ki、Aoyama Shinya、Shibata Shigenobu
  • Journal Title: Nutrients Volume: 10 Issue: 11 Pages: 1763-1763
  • DOI: 10.3390/nu10111763
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Screen time duration or timing? Exploring the relationship between screen time and obesity, physical activity, dry eyes, and learning ability in elementary school children. (2020)
  • Author(s): 峯下由衣、金鉉基、神藤貴江、千々木華子、難波拓哉、尾根田諭、古橋捷太、桑原麻衣、諏訪間杏、勢能あゆみ、柴田重信
  • Organizer: 日本時間生物学会
• [Presentation] Effects of acute endurance exercise performed in the morning and evening on 24-h interstitial fluid glucose levels (2019)
  • Author(s): Kim, H,K., Furuhashi, S., Fukazawa, M., Okubo, J., Ozaki, M., Chijiki, H., Nanba, T., Oneda, S., Shinto, T., Tabata, H., Takahashi, M., Sakamoto, S., Shibata, S
  • Organizer: European College of Sport Science
  • Int'l Joint Research
• [Presentation] 朝の魚肉タンパク質の摂取が高齢者の骨格筋量および筋力に及ぼす影響 (2019)
  • Author(s): 金 鉉基、難波拓哉、深澤真由子、大久保仁、尾崎真実帆、千々木華子、 内田健志、加藤綾華、中岡隆志、柴田重信
  • Organizer: 日本サルコペニア・フレイル学会
  • Int'l Joint Research
• [Presentation] Effects of acute endurance exercise performed in the morning and evening on 24-h interstitial fluid glucose levels. (2019)
  • Author(s): Kim, H-K., Furuhashi, S., Fukazawa, M., Okubo, J., Ozaki, M., Chijiki, H., Nanba, T., Oneda, S., Shinto, T., Tabata, H., Takahashi, M., Sakamoto, S., Shibata, S
  • Organizer: Annual Congress of the European College of Sport Science
  • Int'l Joint Research
• [Book] 時間栄養学 (2020)
  • Author(s): 柴田 重信、金 鉉基ほか
  • Total Pages: 256
  • Publisher: 化学同人
  • ISBN: 9784759820362