Systemic effects of exercise on mitochondrial adaptations
| Project/Area Number |
18K17941
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Kanagawa University |
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Principal Investigator |
Kitaoka Yu 神奈川大学, 人間科学部, 准教授 (30726914)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | エクサカイン / 運動 / エクソソーム / ミトコンドリア |
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| Outline of Final Research Achievements |
We found that blood samples taken immediately after high-intensity interval exercise contain "exerkine" that enhances glycolytic capacity and mitochondrial respiratory function in skeletal muscle cells. Our results suggested that these factors may be secreted by exercise in extracellular vesicles. However, it remains unclear that whether "exerkine" is actually involved in the chronic adaptation of the whole body.
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| Academic Significance and Societal Importance of the Research Achievements |
運動は健康の維持および増進に貢献すると考えられているが、そのメカニズムは不明な点が多い。近年、骨格筋から分泌される生理活性因子であるマイオカインの重要性が示唆されているが、運動効果をもたらす物質は骨格筋由来の因子だけとは限らない。本研究では運動によって体内で分泌される因子をエクサカインと定義し、細胞外小胞に含まれる形で分泌されるエクサカインが運動による身体の適応に関与する可能性を示した。
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Report
(4 results)
Research Products
(11 results)
