The effects of vitamin E on adipocyte differentiation and the mechanisms.
| Project/Area Number |
18K17942
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | National Center for Child Health and Development (2019-2020)
Kanagawa Institute of Technology (2018) |
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Principal Investigator |
Tanaka Rieko 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, (非)研究員 (80579962)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Tocopherol / Thermogenic adipocyte / Beige adipocyte / Brown adipocyte / UCP1 / PGC-1α / p38 MAPK / ビタミンE / 熱産生型脂肪細胞 / ベージュ脂肪細胞 / 褐色脂肪細胞 / 肥満 / 脂肪細胞 / 転写因子 / microRNA |
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| Outline of Final Research Achievements |
Activation of thermogenic adipocytes has been considered an attractive target for weight loss and treatment of metabolic disease. Thermogenic adipocytes (beige and brown) adipocytes, which constitute brown adipose tissue (BAT), have many mitochondria containing uncoupling protein 1 (UCP1). We found that tocopherols upregulate peroxisome proliferator-activated receptor γ co-activator-1 α (PGC1-α) activation via p38 MAPK pathway and promotes thermogenic adipocyte differentiation in mammalian adipocytes. Our present findings suggest that tocopherols have a potential ability to prevent obesity and obesity-related disease by enhance of energy consumption in adipocyte.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によってビタミンE同族体のうち特にδ-トコフェロールが褐色脂肪組織における熱産生を亢進する事が明らかとなり、δ-トコフェロールの摂取が肥満を抑制する可能性が示された。これらの知見は肥満をターゲットとした医薬品やサプリメントの開発シーズとして非常に有用である。また、本研究の成果はビタミンEの機能として報告されている代謝疾患の改善に、脂肪組織における熱産生能の向上が関与する可能性を示している。
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Report
(4 results)
Research Products
(10 results)
