| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Activation of thermogenic adipocytes has been considered an attractive target for weight loss and treatment of metabolic disease. Thermogenic adipocytes (beige and brown) adipocytes, which constitute brown adipose tissue (BAT), have many mitochondria containing uncoupling protein 1 (UCP1). We found that tocopherols upregulate peroxisome proliferator-activated receptor γ co-activator-1 α (PGC1-α) activation via p38 MAPK pathway and promotes thermogenic adipocyte differentiation in mammalian adipocytes. Our present findings suggest that tocopherols have a potential ability to prevent obesity and obesity-related disease by enhance of energy consumption in adipocyte.
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