| Project/Area Number |
18K17976
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Keio University |
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Principal Investigator |
AW WanPing 慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 (20736441)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Rice bran / colitis / gut microbiome / metabolome / Rice Bran / DSS colitis / Metabolome / Microbiome / rice bran / Nutriomics / Gut Microbiome / Gut Metabolome / Functional Food |
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| Outline of Final Research Achievements |
Our results suggest that colitic mice fed 10% RB supplemented diet had higher abundance of Clostridiaceae. Fecal microbiota transplantation from RB-fed mice suppressed colitis. This strongly suggests that RB suppresses colitis through gut microbiota modulation.The fecal metabolome profile was dynamically changed by RB intake. Enrichment analysis revealed that RB intervention enriched the tryptophan metabolism pathway. Our results revealed that RB improves colitis via gut environment modulation.
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| Academic Significance and Societal Importance of the Research Achievements |
We have provided scientific evidence that rice bran suppresses colitis and we could apply it to recommending IBD patients to consume unpolished brown rice instead of white rice. Our methodology in elucidating the anti-colitic mechanisms of rice bran could also be applied to other food products.
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