Lifestyle-related factors associated with low back pain: a cross-sectional analysis using a large-scale health checkup data

• Project/Area Number: 18K17979
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Showa University
• Principal Investigator: Yoshimoto Takahiko 昭和大学, 医学部, 講師 (20747365)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2018: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
• Keywords: 腰痛 / 労働者 / 生活習慣 / 健康診断 / メタボリックシンドローム / 脂質

Outline of Final Research Achievements

Using health checkup data from a large cohort of Japanese adults, we investigated the association of low back pain with lifestyle behaviors, blood sample, and metabolic syndrome. We found that abnormal lipid levels (low HDL-C, and high LDL-C/HDL-C ratio) and a clustering of unhealthy lifestyles were significantly associated with low back pain. Moreover, the significant relationship between metabolic syndrome and low back pain in women was observed. These findings may provide implications for better preventive strategy and management of low back pain, considering modifiable lifestyle factors.

Academic Significance and Societal Importance of the Research Achievements

生活習慣に密接に関連する血清脂質やメタボリックシンドロームと腰痛の関連を明らかにしたことは、腰痛の発症機序の検討、または保健指導の現場での活用等において有用な基礎資料となりうる。また、不健康な生活習慣要因の集積と腰痛症に関する知見は我が国初の報告であり、国民病ともいえる腰痛に対して、modifiableな要素である生活習慣という視点を含めた新たな対策の開発に寄与するものと考える。

Research Products

• [Journal Article] Clustering of Lifestyle Factors and Its Association with Low Back Pain: A Cross-Sectional Study of Over 400,000 Japanese Adults (2020)
  • Author(s): Yoshimoto Takahiko、Ochiai Hirotaka、Shirasawa Takako、Nagahama Satsue、Uehara Akihito、Muramatsu Jun、Kokaze Akatsuki
  • Journal Title: Journal of Pain Research Volume: Volume 13 Pages: 1411-1419
  • DOI: 10.2147/jpr.s247529
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study (2019)
  • Author(s): Yoshimoto Takahiko、Ochiai Hirotaka、Shirasawa Takako、Nagahama Satsue、Uehara Akihito、Sai Shogo、Kokaze Akatsuki
  • Journal Title: Biology of Sex Differences Volume: 10 Issue: 1
  • DOI: 10.1186/s13293-019-0249-3
  • Peer Reviewed / Open Access
• [Journal Article] Association between serum lipids and low back pain among a middle-aged Japanese population: a large-scale cross-sectional study (2018)
  • Author(s): Yoshimoto Takahiko、Ochiai Hirotaka、Shirasawa Takako、Nagahama Satsue、Kobayashi Mariko、Minoura Akira、Miki Ayako、Chen Yingli、Hoshino Hiromi、Kokaze Akatsuki
  • Journal Title: Lipids in Health and Disease Volume: 17 Issue: 1 Pages: 266-266
  • DOI: 10.1186/s12944-018-0907-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 女性における生活習慣リスク要因の集積と腰痛症との関連（ZRF study 第19報） (2019)
  • Author(s): 吉本隆彦、落合裕隆、白澤貴子、長濱さつ絵、小風暁
  • Organizer: 日本公衆衛生学会総会
• [Presentation] 腰痛症とメタボリックシンドロームおよびその構成要素の集積との関連（ZRF study 第15報） (2019)
  • Author(s): 吉本隆彦、落合裕隆、白澤貴子、長濱さつ絵、小林真理子、箕浦明、星野祐美、小風暁
  • Organizer: 日本疫学会学術総会
• [Presentation] 中年者における血清脂質と腰痛症の関連（ZRF study 第12報） (2018)
  • Author(s): 吉本隆彦、落合裕隆、白澤貴子、箕浦明、長濱さつ絵、小林真理子、芦川真名美、星野祐美、小風暁
  • Organizer: 日本衛生学会学術総会