| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
This study was carried out to investigate the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on urinary bladder smooth muscle (UBSM) and gastrointestinal smooth muscle (GISM) and the intracellular signal transduction via prostanoid TP receptors in UBSM. The results were as follow: 1) Contractile prostanoids stimulate the UBSM TP receptors, and enhanced the UBSM mechanical activities; 2) The UBSM mechanical activities enhanced by TP receptor stimulations were elicited via the activation of Ca2+ channels; 3) The UBSM contractions induced by electrical field stimulation (EFS) was enhanced by a prostanoid TP receptor agonist, and this augmentation was suppressed by DHA; 4) EPA enhances the UBSM mechanical activities; 5) DHA and EPA non-selectively suppressed the GISM contractions.
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