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Statistical evaluation of low-dose radiation effects allowing for measurement errors

Research Project

Project/Area Number 18K18019
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 60030:Statistical science-related
Research InstitutionRadiation Effects Research Foundation

Principal Investigator

Misumi Munechika  公益財団法人放射線影響研究所, 統計部, 副部長 (90457432)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線疫学 / 測定誤差 / 統計的方法 / 線量反応 / 放射線量推定 / 線量反応曲線 / 放射線リスク / 統計学 / 疫学 / 低線量被曝
Outline of Final Research Achievements

In radiation epidemiology, when the radiation dose-response is estimated using the radiation dose estimate with measurement errors, the shape of the dose-response curve is affected by correcting the measurement error without ignoring it even in the low dose range. Simulation studies based on the setting of epidemiological data of Atomic bomb survivors show that measurement errors affect the shape of the dose-response and that the estimated shape of the dose-response could be different by the methods for the measurement error correction. Furthermore, through discussions based on the results, in collaboration with members of the International Commission on Radiological Protection (ICRP), a paper that predicts the lifetime risk of radiation in populations around the world, which can be an important source for future radiation protection discussions, has been published.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、低い線量域でも被曝放射線量推定値の測定誤差の影響を補正する必要性と、測定誤差の線量反応曲線の形への影響も考慮した解析が必要であることを示した。原爆被爆者の研究は放射線による死亡やがん罹患リスクの量反応曲線を直線で考える根拠となってきた。その最新のがん罹患率の線量反応にこれまでの報告と異なる結果が出たことについて、シミュレーションによって説明する試みを紹介することで、放射線影響研究の研究者と議論した。その結果として、国際放射線防護委員会(ICRP)の主要メンバーと放射線防護基準の議論で資料となる科学論文を発表した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results)

  • [Journal Article] Lifetime mortality risk from cancer and circulatory disease predicted from the Japanese atomic bomb survivor Life Span Study data taking account of dose measurement error2020

    • Author(s)
      Mark P Little, David Pawel, Munechika Misumi, Nobuyuki Hamada, Harry M Cullings, Richard Wakeford, Kotaro Ozasa
    • Journal Title

      Radiation Research

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Methods for regression analysis with exposure uncertainty in radiation risk analysis2021

    • Author(s)
      三角宗近
    • Organizer
      統計関連学会連合大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Radiation risk analysis and statistical methods for the long-term follow-up studies of Japanese atomic bomb survivor cohort2021

    • Author(s)
      三角宗近
    • Organizer
      WNAR 2021 (Annual meeting of the Western North American Region of the International Biometric Society))
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Statistical evaluation of low dose radiation dose-response allowing for measurement errors2019

    • Author(s)
      Munechika Misumi
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bayesian dosimetric error models fitted to Japanese A-bomb Life Span Study mortality data and predicted population cancer and non-cancer risk2019

    • Author(s)
      Mark P Little, Munechika Misumi, Kotaro Ozasa, Eric J Grant
    • Organizer
      16th International Congress of Radiation Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Consideration of low-dose radiation risk in the presence of measurement error from a statistical perspective2019

    • Author(s)
      Munechika Misumi
    • Organizer
      5th International Symposium on Radiation Protection
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement error correction for radiation risk estimation in atomic bomb survivor studies2019

    • Author(s)
      Munechika Misumi
    • Organizer
      WNAR (Western north American region of the International Biometric Society) annual meeting 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of measurement error in radiation dose estimate for dose-response modeling of cancer risk2019

    • Author(s)
      Munechika Misumi
    • Organizer
      40th Annual conference of the International Society for Clinical Biostatistics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] An evaluation of measurement error correction in radiation risk analysis focusing on low dose exposure2018

    • Author(s)
      Munechika Misumi
    • Organizer
      SRA(Society for risk analysis) 2018 annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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