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Elucidation of the acquisition mechanism of neural substrate for the perception of sound texture

Research Project

Project/Area Number 18K18138
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 61060:Kansei informatics-related
Research InstitutionThe University of Tokyo

Principal Investigator

SHIRAMATSU Tomoyo  東京大学, 大学院情報理工学系研究科, 助教 (30750020)

Project Period (FY) 2019-02-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords音楽 / 質感 / 臨界期 / 聴覚野 / 和音 / 嗜好性 / 受容野 / 聴皮質
Outline of Final Research Achievements

This study aimed to elucidate the mechanisms underlying the acquisition of the neural basis for the perception and preference of sound texture. First, we compared the preference for harmonicity of two-tone chord and the response properties of the auditory cortex in rats, which were exposed to consonant or dissonant chords before and after the critical period. The results showed that exposure to chords during the critical period affected the preference and response properties of the auditory cortex.
Second, we confirmed that the information representation of musical rhythm can be explained by the properties of adaptation in the auditory cortex and that animal models show synchronized movements to the beat of music as well as humans do. These results suggest that the neural basis of information processing for sound texture is influenced not only by innate neural properties such as adaptation but also by neural properties acquired through auditory experiences during the critical period.

Academic Significance and Societal Importance of the Research Achievements

和音に代表される,音の質感の知覚能力を,我々が生得的に有しているのか,あるいは経験や学習によって後天的に獲得するのかは,これまで様々な分野で議論されてきた.心理物理学や神経科学では,生後間もない乳児や,音楽に接する機会のない地域の住民,動物モデルを対象として,和音の協和性の知覚能力や選好性とその神経基盤における,生得的要素と後天的要素の分離が試みられてきた.本研究は,後天的要素の検討において,感覚系の臨界期,すなわち,生後に受容した聴覚刺激に応じて神経回路が劇的に発達する時期と,臨界期以降の可塑性との区別を,動物モデルにより初めて試みており,当該分野の知見を大きく広げたと言える.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 5 results) Presentation (42 results) (of which Int'l Joint Research: 7 results,  Invited: 7 results)

  • [Journal Article] Information Processing Capacity in the Rat Auditory Cortex2022

    • Author(s)
      石田直輝,窪田智之,伊藤圭基,白松(磯口)知世,諏訪瑛介,高橋宏知
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 142 Issue: 5 Pages: 569-577

    • DOI

      10.1541/ieejeiss.142.569

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2022-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oddball-irrelevant visual stimuli cross-modally attenuate auditory mismatch negativity in rats2022

    • Author(s)
      Tomoyo Isoguchi Shiramatsu, Kanato Mori, Hirokazu Takahashi
    • Journal Title

      NeuroReport

      Volume: 33 Issue: 8 Pages: 363-368

    • DOI

      10.1097/wnr.0000000000001793

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous beat synchronization in rats: Neural dynamics and motor entrainment2022

    • Author(s)
      Yoshiki Ito, Tomoyo Isoguchi Shiramatsu, Naoki Ishida, Karin Oshima, Kaho Magami, Hirokazu Takahashi
    • Journal Title

      Science Advances

      Volume: 8 Issue: 45

    • DOI

      10.1126/sciadv.abo7019

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oddball-irrelevant visual stimuli cross-modally attenuate auditory mismatch negativity in rats2022

    • Author(s)
      Tomoyo Isoguchi Shiramatsu, Kanato Mori, Hirokazu Takahashi
    • Journal Title

      NeuroReport

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deviance Detection Property in Dissociated Cultures of Neurons2021

    • Author(s)
      窪田 智之,櫻山 和浩,白松(磯口) 知世,高橋 宏知
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 141 Issue: 5 Pages: 661-667

    • DOI

      10.1541/ieejeiss.141.661

    • NAID

      130008033197

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Mapping of Neural Activities in Auditory and Visual Cortex of Rat2021

    • Author(s)
      Mori Kanato、Isoguchi Shiramatsu Tomoyo、Ishizu Kotaro、Takahashi Hirokazu
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 141 Issue: 5 Pages: 614-619

    • DOI

      10.1541/ieejeiss.141.614

    • NAID

      130008033223

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Experimental System to Evaluate Auditory Perception Induced by Microstimulation of Auditory Thalamus of Rats2021

    • Author(s)
      Isoguchi Shiramatsu Tomoyo、Abe Taiki、Ishizu Kotaro、Takahashi Hirokazu
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 141 Issue: 5 Pages: 627-633

    • DOI

      10.1541/ieejeiss.141.627

    • NAID

      130008033228

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous mapping of neural activities in auditory and visual cortex of rat2021

    • Author(s)
      Kanato Mori, Shiramatsu Isoguchi Tomoyo, Kotaro Ishizu, Hirokazu Takahashi
    • Journal Title

      Electronics and Communications in Japan

      Volume: 104 Issue: 3

    • DOI

      10.1002/ecj.12322

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Auditory, Visual, and Cross-Modal Mismatch Negativities in the Rat Auditory and Visual Cortices2021

    • Author(s)
      Shiramatsu Tomoyo Isoguchi、Mori Kanato、Ishizu Kotaro、Takahashi Hirokazu
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 721476-721476

    • DOI

      10.3389/fnhum.2021.721476

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Information flow in the rat thalamo-cortical system: spontaneous vs. stimulus-evoked activities2021

    • Author(s)
      Ishizu Kotaro、Shiramatsu Tomoyo I.、Hitsuyu Rie、Oizumi Masafumi、Tsuchiya Naotsugu、Takahashi Hirokazu
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19252-19252

    • DOI

      10.1038/s41598-021-98660-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経細胞の分散培養系の逸脱検出特性2021

    • Author(s)
      窪田智之,櫻山和浩,白松(磯口)知世,高橋宏知
    • Journal Title

      電気学会論文誌C電子情報システム部門誌

      Volume: 141

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 視床刺激が聴知覚に及ぼす影響を評価する実験系の構築2021

    • Author(s)
      白松(磯口)知世,阿部泰己,石津光太郎,高橋宏知
    • Journal Title

      電気学会論文誌C電子情報システム部門誌

      Volume: 141

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラット聴覚野と視覚野からの皮質脳波の同時計測2021

    • Author(s)
      森叶人,白松(磯口)知世,石津光太郎,高橋宏知
    • Journal Title

      電気学会論文誌C電子情報システム部門誌

      Volume: 141

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vagus nerve stimulation (VNS)-induced layer-specific modulation of evoked responses in the sensory cortex of rats2020

    • Author(s)
      Hirokazu Takahashi, Tomoyo I. Shiramatsu, Rie Hitsuyu, Kenji Ibayashi, and Kensuke Kawai
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 8932-8932

    • DOI

      10.1038/s41598-020-65745-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mismatch-negativity (MMN) in animal models: Homology of human MMN?2020

    • Author(s)
      Shiramatsu Isoguchi Tomoyo、Takahashi Hirokazu
    • Journal Title

      Hearing Research

      Volume: - Pages: 107936-107936

    • DOI

      10.1016/j.heares.2020.107936

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Cortical oscillations modulated by vagus nerve stimulation in auditory pathways2023

    • Author(s)
      Shinichi Kumagai, Tomoyo Isoguchi Shiramatsu, Akane Matsumura, Kensuke Kawai, Hirokazu Takahashi
    • Organizer
      2022 MidWinter Meeting of Association for Research in Otolaryngology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット聴覚野の情報処理容量に対する音楽曝露の効果2023

    • Author(s)
      石田 直輝,白松(磯口) 知世,高橋 宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Common Mechanism Underlying Multimodal Integration2023

    • Author(s)
      Hexin Xu, Amit Yaron, Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 音環境に依存したげっ歯類の超音波コミュニケーション2023

    • Author(s)
      高木 永遠,大島 果林,白松(磯口) 知世,高橋 宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラット聴覚野における情報処理容量の局在構造2022

    • Author(s)
      石田 直輝,窪田 智之,伊藤 圭基,白松(磯口) 知世,高橋 宏知
    • Organizer
      聴覚研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラットの社会的嗜好性に対する音楽の影響の検討2022

    • Author(s)
      大島 果林,白松(磯口) 知世,高橋 宏知
    • Organizer
      聴覚研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラットの社会的結束形成に対する音楽の影響の評価系構築2022

    • Author(s)
      大島 果林,白松-磯口 知世,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラット聴覚野の情報処理容量2022

    • Author(s)
      石田 直輝,窪田 智之,伊藤 圭基,白松-磯口 知世,諏訪 瑛介,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 長期間の音楽曝露によるラット聴覚野の時間情報表現の変化2022

    • Author(s)
      白松-磯口 知世,石田 直輝,大島 果林,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 情動に対する音楽の影響を動物モデルで調べるための実験系2022

    • Author(s)
      山木 崚太郎,石田 直輝,白松-磯口 知世,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Memory Traces in Dissociated Cultures of Neurons2022

    • Author(s)
      Zhuo Zhang, Amit Yaron, Eisuke Suwa, Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Presentation] 迷走神経刺激による聴覚野の神経活動の変化2022

    • Author(s)
      熊谷 真一,松村 茜,白松-磯口 知世,川合 謙介,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラット聴覚野の神経細胞が有する情報処理容量の不均一性2022

    • Author(s)
      石田 直輝,窪田 智之,伊藤 圭基,白松(磯口) 知世,高橋 宏知
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Direction of Multisensory Illusion is Influenced by Stimulus Detectability2022

    • Author(s)
      許 鶴馨,Amit Yaron,白松?磯口 知世,高橋 宏知
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Cortical mapping of auditory, visual, and cross-modal mismatch negativities in rat2022

    • Author(s)
      Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
    • Organizer
      The 9th Mismatch Negativity conference(MMN 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Beat synchronization in rat2022

    • Author(s)
      Hirokazu Takahashi, Yoshiki Ito, Tomoyo Isoguchi Shiramatsu, Naoki Ishida, Karin Oshima, Kaho Magami
    • Organizer
      The 9th Mismatch Negativity conference(MMN 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A new functional role of MMN-like response beyond simple deviance detection: using animal models to elucidate the underlying neural mechanisms of schizophrenia2022

    • Author(s)
      Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
    • Organizer
      The 9th Mismatch Negativity conference(MMN 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Deviance Detection Properties in Dissociated Cultures of Neurons2022

    • Author(s)
      Zhuo Zhang, Amit Yaron, Tomoyo Isoguchi Shiramatsu, Hirokazu Takahashi
    • Organizer
      The 9th Mismatch Negativity conference(MMN 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sensitivity to Complex Statistical Regularities in Neuronal Culture2022

    • Author(s)
      Amit Yaron, Zhuo Zhang, Tomoyo Isoguchi Shiramatsu, Zenas C. Chao, Hirokazu Takahashi
    • Organizer
      The 9th Mismatch Negativity conference(MMN 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 情動に対する音楽の影響を動物モデルで調べるための実験系2022

    • Author(s)
      山木 崚太郎,白松(磯口) 知世,石田 直輝,高橋 宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 感覚野における迷走神経刺激療法の動作原理の検証2022

    • Author(s)
      松村 茜,熊谷 真一,白松(磯口) 知世,川合 謙介,高橋 宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] げっ歯類の社会的行動に対する音楽の影響2022

    • Author(s)
      大島 果林,白松(磯口) 知世,高橋 宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Long-term exposure to classical music affects temporal characteristics of cortical representation in rat auditory cortex2022

    • Author(s)
      白松-磯口 知世,石田 直輝,大島 果林,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2021 Research-status Report
  • [Presentation] An experimental system to investigate the effects of music on emotion in animal models2022

    • Author(s)
      山木 崚太郎,白松-磯口 知世,石田 直輝,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2021 Research-status Report
  • [Presentation] Behavioral assays to evaluate the effect of music on social bonding in rats2022

    • Author(s)
      大島 果林,白松-磯口 知世,高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2021 Research-status Report
  • [Presentation] Modulation of neural activities in auditory cortex by vagus nerve stimulation2022

    • Author(s)
      熊谷 真一, 松村 茜, 白松-磯口 知世, 川合 謙介, 高橋 宏知
    • Organizer
      NEURO2022
    • Related Report
      2021 Research-status Report
  • [Presentation] 臨界期前後の和音曝露が嗜好性に及ぼす影響の評価2021

    • Author(s)
      白松(磯口) 知世,眞神 花帆,高橋 宏知
    • Organizer
      聴覚研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 音楽のビートに同期したラットの頭部運動2021

    • Author(s)
      高橋 宏知,伊藤 圭基,白松(磯口) 知世,石田 直輝,眞神 花帆
    • Organizer
      聴覚研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 臨界期における音環境と生育後の嗜好性との関係2021

    • Author(s)
      白松(磯口) 知世,眞神 花帆,高橋 宏知
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ラット聴覚野における情報処理容量の局在構造2021

    • Author(s)
      石田 直輝,窪田 智之,伊藤 圭基,白松(磯口) 知世,高橋 宏知
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2021 Research-status Report
  • [Presentation] ラットの聴知覚に対する迷走神経刺激の影響2021

    • Author(s)
      松村 茜,熊谷 真一,白松(磯口) 知世,川合 謙介,高橋 宏知
    • Organizer
      電気学会 電子・情報・システム部門大会
    • Related Report
      2021 Research-status Report
  • [Presentation] げっ歯類モデルにおけるミスマッチネガティビティの多点計測2021

    • Author(s)
      白松(磯口)知世,高橋宏知
    • Organizer
      音響学会2021年春季研究発表会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ラット聴覚野における情報処理容量の計測2021

    • Author(s)
      石田直輝,窪田智之,伊藤圭基,白松(磯口)知世,高橋宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 齧歯類におけるビート知覚の神経基盤2021

    • Author(s)
      伊藤圭基,白松(磯口)知世,石田直輝,眞神花帆,高橋宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 多感覚情報処理が脳の逸脱検出に及ぼす影響2021

    • Author(s)
      森叶人,白松(磯口)知世,高橋宏知
    • Organizer
      電気学会研究会医用・生体工学研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] The optimal beat frequency for the neural activities in the auditory cortex of rats2021

    • Author(s)
      Yoshiki Ito, Tomoyo I. Shiramatsu, Hirokazu Takahashi
    • Organizer
      Association For Research In Otolaryngology 44th Annual MidWinter Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 麻酔下ラットにおける視聴覚ミスマッチネガティビティ2020

    • Author(s)
      森 叶人,白松 (磯口) 知世,高橋 宏知
    • Organizer
      第4回MMN研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] VNSによる聴皮質と視床の受容野の変化2020

    • Author(s)
      白松-磯口知世, 井林賢志, 日露理英, 川合謙介, 高橋宏知
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] げっ歯類モデルにおけるミスマッチネガティビティの多点計測2020

    • Author(s)
      白松(磯口)知世,高橋宏知
    • Organizer
      日本音響学会2020年春季研究発表会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 迷走神経刺激がラット聴皮質の定常的な神経活動の情報表現に及ぼす影響2019

    • Author(s)
      白松(磯口)知世,井林賢志,川合謙介,高橋宏知
    • Organizer
      日本音響学会2019年6月度聴覚研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 迷走神経刺激による視床-聴皮質の可塑的変化2019

    • Author(s)
      白松(磯口)知世,井林賢志,日露理英,川合謙介,高橋宏知
    • Organizer
      2019年電気学会電子・情報・システム部門大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 麻酔下ラット聴皮質における単一試行のミスマッチネガティビティ2019

    • Author(s)
      白松(磯口)知世,高橋宏知
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2024-01-30  

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