Developing a comprehensive and interactive e-learning system of neuroimaging

• Project/Area Number: 18K18164
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 62030:Learning support system-related
• Research Institution: University of Tsukuba
• Principal Investigator: Nemoto Kiyotaka 筑波大学, 医学医療系, 准教授 (80550152)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 脳画像解析 / e-ラーニング / 脳画像解析 e-ラーニング

Outline of Final Research Achievements

I developed an integrated neuroimaging analysis framework which consisted of neuroimaging analysis system, e-learning materials, and interactive discussion forum. With this framework, even novice researchers can easily setup an enviroment for neuroimaging analysis, and even experienced researchers make full use of discussion forum to publish their data.

Academic Significance and Societal Importance of the Research Achievements

本研究は、「脳画像研究の裾野を広げる」ところに意義がある。脳画像解析は特殊なソフトウェアを必要とするため、そのセットアップは容易ではない。本研究で開発したシステムを利用することにより、最初のハードルを容易にこえられるようになった。また、研究者が自習できるコンテンツを多く用意したこと、さらに、関心のある研究者がディスカッションできる環境を構築したことにより、様々な研究者の研究テーマの論文化を進めることができた。

Research Products

• [Journal Article] Abnormal White Matter Microstructure in the Limbic System Is Associated With Tuberous Sclerosis Complex-Associated Neuropsychiatric Disorders (2022)
  • Author(s): Sato, Akemi Tominaga, Koji Iwatani, Yoshiko Kato, Yoko Wataya-Kaneda, Mari Makita, Kai Nemoto, Kiyotaka Taniike, Masako Kagitani-Shimono, Kuriko
  • Journal Title: Frontiers in Neurology Volume: 13 Pages: 1-15
  • DOI: 10.3389/fneur.2022.782479
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic balance deficit and the neural network in Alzheimer's disease and mild cognitive impairment (2022)
  • Author(s): Ide Ryotaro、Ota Miho、Hada Yasushi、Watanabe Serina、Takahashi Takumi、Tamura Masashi、Nemoto Kiyotaka、Arai Tetsuaki
  • Journal Title: Gait & Posture Volume: 93 Pages: 252-258
  • DOI: 10.1016/j.gaitpost.2022.01.018
  • Peer Reviewed / Open Access
• [Journal Article] Brain conditions mediate the association between aging and happiness (2022)
  • Author(s): Kokubun Keisuke、Nemoto Kiyotaka、Yamakawa Yoshinori
  • Journal Title: Scientific Reports Volume: 12 Issue: 1
  • DOI: 10.1038/s41598-022-07748-6
  • Peer Reviewed
• [Journal Article] Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder (2022)
  • Author(s): Tomiyama H, Murayama K, Nemoto K, Hasuzawa S, Mizobe T, Kato K, Matsuo A, Ohono A, Kang M, Togao O, Hiwatashi A, Ishigami K, Nakao T.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 116 Pages: 110516-110516
  • DOI: 10.1016/j.pnpbp.2022.110516
  • Peer Reviewed / Open Access
• [Journal Article] Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis (2021)
  • Author(s): Toko Megumi、Kitamura Juri、Ueno Hiroki、Ohshita Tomohiko、Nemoto Kiyotaka、Ochi Kazuhide、Higaki Toru、Akiyama Yuji、Awai Kazuo、Maruyama Hirofumi
  • Journal Title: Internal Medicine Volume: 60 Issue: 1 Pages: 39-46
  • DOI: 10.2169/internalmedicine.5058-20
  • NAID: 130007965450
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive-compulsive disorder. (2021)
  • Author(s): Tomiyama H, Murayama K, Nemoto K, Tomita M, Hasuzawa S, Mizobe, T, Kato K, Ohno A, Tsuruta S, Hiwatashi A, Nakao T
  • Journal Title: Human Brain Mapping Volume: Nov 24 Issue: 3 Pages: 974-984
  • DOI: 10.1002/hbm.25699
  • Peer Reviewed / Open Access
• [Journal Article] Grey-matter brain healthcare quotient and cognitive function: A large cohort study of an MRI brain screening system in Japan (2021)
  • Author(s): Watanabe Keita、Kakeda Shingo、Nemoto Kiyotaka、Onoda Keiichi、Yamaguchi Shuhei、Kobayashi Shotai、Yamakawa Yoshinori
  • Journal Title: Cortex Volume: 145 Pages: 97-104
  • DOI: 10.1016/j.cortex.2021.09.009
  • Peer Reviewed
• [Journal Article] Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes (2021)
  • Author(s): Midorikawa Manabu、Suzuki Hiroaki、Suzuki Yasuhiro、Yamauchi Kazuyoshi、Sato Hiroyuki、Nemoto Kiyotaka、Sugano Yoko、Iwasaki Hitoshi、Sekiya Motohiro、Yatoh Shigeru、Yahagi Naoya、Hada Yasushi、Arai Tetsuaki、Shimano Hitoshi
  • Journal Title: Journal of Diabetes Research Volume: 2021 Pages: 1-14
  • DOI: 10.1155/2021/9961612
  • Peer Reviewed / Open Access
• [Journal Article] Gymkhana and pylon slalom driving training effects on the cerebellum structure (2021)
  • Author(s): Shimizu Toshiyuki、Gheorghe Lucian A.、Nemoto Kiyotaka、Horie Tomohiko、Takano Susumu、Haida Munetaka
  • Journal Title: Neuroscience Letters Volume: 765 Pages: 136281-136281
  • DOI: 10.1016/j.neulet.2021.136281
  • Peer Reviewed
• [Journal Article] Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects (2021)
  • Author(s): Ohi Kazutaka、Nemoto Kiyotaka、Kataoka Yuzuru、Sugiyama Shunsuke、Muto Yukimasa、Shioiri Toshiki、Kawasaki Yasuhiro
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 110 Pages: 110291-110291
  • DOI: 10.1016/j.pnpbp.2021.110291
  • Peer Reviewed
• [Journal Article] Structural Plastic Changes of Cortical Gray Matter Revealed by Voxel-Based Morphometry and Histological Analyses in a Monkey Model of Central Post-Stroke Pain (2021)
  • Author(s): Nagasaka Kazuaki、Nemoto Kiyotaka、Takashima Ichiro、Bando Daigo、Matsuda Keiji、Higo Noriyuki
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 10 Pages: 4439-4449
  • DOI: 10.1093/cercor/bhab098
  • Peer Reviewed
• [Journal Article] Differentiating Dementia with Lewy Bodies and Alzheimer's Disease by Deep Learning to Structural MRI (2021)
  • Author(s): Nemoto Kiyotaka、Sakaguchi Hiromasa、Kasai Wataru、Hotta Masatoshi、Kamei Ryotaro、Noguchi Tomoyuki、Minamimoto Ryogo、Arai Tetsuaki、Asada Takashi
  • Journal Title: Journal of Neuroimaging Volume: - Issue: 3 Pages: 579-587
  • DOI: 10.1111/jon.12835
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between white matter microstructure and work hours (2021)
  • Author(s): Matsumoto Junya、Fukunaga Masaki、Miura Kenichiro、Nemoto Kiyotaka、Koshiyama Daisuke、Okada Naohiro、Morita Kentaro、Yamamori Hidenaga、Yasuda Yuka、Fujimoto Michiko、Hasegawa Naomi、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
  • Journal Title: Neuroscience Letters Volume: 740 Pages: 135428-135428
  • DOI: 10.1016/j.neulet.2020.135428
  • Peer Reviewed / Open Access
• [Journal Article] Association between the superior longitudinal fasciculus and perceptual organization and working memory: A diffusion tensor imaging study (2020)
  • Author(s): Koshiyama Daisuke、Fukunaga Masaki、Okada Naohiro、Morita Kentaro、Nemoto Kiyotaka、Yamashita Fumio、Yamamori Hidenaga、Yasuda Yuka、Matsumoto Junya、Fujimoto Michiko、Kudo Noriko、Azechi Hirotsugu、Watanabe Yoshiyuki、Kasai Kiyoto、Hashimoto Ryota
  • Journal Title: Neuroscience Letters Volume: 738 Pages: 135349-135349
  • DOI: 10.1016/j.neulet.2020.135349
  • Peer Reviewed / Open Access
• [Journal Article] Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA (2020)
  • Author(s): Koshiyama Daisuke、Miura Kenichiro、Nemoto Kiyotaka、Okada Naohiro、Matsumoto Junya、Fukunaga Masaki、Hashimoto Ryota
  • Journal Title: Human Brain Mapping Volume: in press Issue: 1 Pages: 182-193
  • DOI: 10.1002/hbm.25040
  • NAID: 120007180728
  • Peer Reviewed / Open Access
• [Journal Article] Early and late effects of electroconvulsive therapy associated with different temporal lobe structures (2020)
  • Author(s): Yamasaki Shimpei、Aso Toshihiko、Miyata Jun、Sugihara Genichi、Hazama Masaaki、Nemoto Kiyotaka、Yoshihara Yujiro、Matsumoto Yukiko、Okada Tomohisa、Togashi Kaori、Murai Toshiya、Takahashi Hidehiko、Suwa Taro
  • Journal Title: Translational Psychiatry Volume: 10 Issue: 1 Pages: 344-344
  • DOI: 10.1038/s41398-020-01025-8
  • Peer Reviewed / Open Access
• [Journal Article] Fish Intake May Affect Brain Structure and Improve Cognitive Ability in Healthy People (2020)
  • Author(s): Kokubun Keisuke、Nemoto Kiyotaka、Yamakawa Yoshinori
  • Journal Title: Frontiers in Aging Neuroscience Volume: 12
  • DOI: 10.3389/fnagi.2020.00076
  • NAID: 120007165464
  • Peer Reviewed / Open Access
• [Journal Article] Plasma levels of matrix metalloproteinase‐9 (MMP‐9) are associated with cognitive performance in patients with schizophrenia (2020)
  • Author(s): Kudo Noriko、Yamamori Hidenaga、Ishima Tamaki、Nemoto Kiyotaka、Yasuda Yuka、Fujimoto Michiko、Azechi Hirotsugu、Niitsu Tomihisa、Numata Shusuke、Ikeda Manabu、Iyo Masaomi、Ohmori Tetsuro、Fukunaga Masaki、Watanabe Yoshiyuki、Hashimoto Kenji、Hashimoto Ryota
  • Journal Title: Neuropsychopharmacology Reports Volume: - Issue: 2 Pages: 150-156
  • DOI: 10.1002/npr2.12098
  • NAID: 120007027668
  • Peer Reviewed / Open Access
• [Journal Article] Brain morphological and functional features in cognitive subgroups of Schizophrenia. (2020)
  • Author(s): Yasuda Y, Okada N, Nemoto K, Fukunaga M, Yamamori H, Ohi K, Koshiyama D, Kudo N, Shiino T, Morita S, Morita K, Azechi H, Fujimoto M, Miura K, Watanabe Y, Kasai K, Hashimoto R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 74(3) Issue: 3 Pages: 191-203
  • DOI: 10.1111/pcn.12963
  • NAID: 120007132757
  • Peer Reviewed / Open Access
• [Journal Article] Differentiation of schizophrenia using structural MRI with consideration of scanner differences: A real-world multi-site study. (2020)
  • Author(s): Nemoto K, Shimokawa T, Fukunaga M, Yamashita F, Tamura M, Yamamori H, Yasuda Y, Azechi H, Kudo N, Watanabe Y, Kido M, Takahashi T, Koike S, Okada N, Hirano Y, Onitsuka T, Yamasue H, Suzuki M, Kasai K, Hashimoto R, Arai T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 74(1) Issue: 1 Pages: 56-63
  • DOI: 10.1111/pcn.12934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals (2019)
  • Author(s): Koshiyama Daisuke、(他38名18番目）Yamamoto Meeri
  • Journal Title: Molecular Psychiatry Volume: 25 Issue: 4 Pages: 883-895
  • DOI: 10.1038/s41380-019-0553-7
  • NAID: 120006980539
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cerebral White Matter Hyperintensity as a Healthcare Quotient (2019)
  • Author(s): Park Kaechang、Nemoto Kiyotaka、Yamakawa Yoshinori、Yamashita Fumio、Yoshida Keitaro、Tamura Masashi、Kawaguchi Atsushi、Arai Tetsuaki、Sasaki Makoto
  • Journal Title: Journal of Clinical Medicine Volume: 8 Issue: 11 Pages: 1823-1823
  • DOI: 10.3390/jcm8111823
  • NAID: 120007133002
  • Peer Reviewed / Open Access
• [Journal Article] Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study (2019)
  • Author(s): Tomiyama H, Nakao T, Murayama K, Nemoto K, Ikari K, Yamada S, Kuwano M, Hasuzawa S, Togao O, Hiwatashi A, Kanba S
  • Journal Title: Neuroimage: Clinical Volume: 24 Pages: 102004-102004
  • DOI: 10.1016/j.nicl.2019.102004
  • NAID: 120007132840
  • Peer Reviewed / Open Access
• [Journal Article] Structural brain network correlated with the resilience to traumatic events in the healthy participants: An MRI study on healthy people in a stricken area of the Great East Japan Earthquake. (2019)
  • Author(s): Ota Miho、Nemoto Kiyotaka、Ishida Ikki、Sato Shinji、Asada Takashi、Arai Tetsuaki、Kunugi Hiroshi
  • Journal Title: Psychological Trauma: Theory, Research, Practice, and Policy Volume: - Issue: 6 Pages: 1035-1039
  • DOI: 10.1037/tra0000517
  • Peer Reviewed
• [Journal Article] Increased brain gyrification in the schizophrenia spectrum (2019)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Nemoto Kiyotaka、Furuichi Atsushi、Kido Mikio、Nishikawa Yumiko、Nakamura Mihoko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 1 Pages: 70-76
  • DOI: 10.1111/pcn.12939
  • NAID: 40022427818
  • Peer Reviewed / Open Access
• [Journal Article] Association of Fatigue and Stress With Gray Matter Volume (2018)
  • Author(s): Kokubun Keisuke、Nemoto Kiyotaka、Oka Hiroki、Fukuda Hiroki、Yamakawa Yoshinori、Watanabe Yasuyoshi
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 12 Pages: 154-154
  • DOI: 10.3389/fnbeh.2018.00154
  • NAID: 120007133698
  • Peer Reviewed / Open Access
• [Presentation] 3次元T1強調MRI画像および安静時脳機能画像を用いた統合失調症補助診断の試み (2021)
  • Author(s): 根本清貴
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 脳イメージング研究における教育環境の構築 (2019)
  • Author(s): 根本清貴
  • Organizer: 第3回ヒト脳イメージング研究会
  • Invited
• [Presentation] 認知機能トレーニングおける運動習慣、処理速度と実行機能の関連 (2019)
  • Author(s): 根本 清貴, レボウイッツ アダム, 山田 典子, 臼庭 等, 田村 昌士, 石川 和宏, 所圭吾, 新井 哲明
  • Organizer: 第115回日本精神神経学会学術総会
• [Presentation] 認知症の行動・心理症状と脳画像の関連 (2019)
  • Author(s): 関根 彩, 中山 顕次郎, 塚田 恵鯉子, 太田 深秀, 東 晋二, 根本 清貴, 新井 哲明
  • Organizer: 第115回日本精神神経学会学術総会
• [Presentation] 脳画像解析学習環境の構築 (2018)
  • Author(s): 根本清貴
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学大会
• [Presentation] Longitudinal Changes of MRI-based Gray Matter Quotient Could Predict the Up-coming Cognitive Decline in the Healthy Elderly (2018)
  • Author(s): Tamura M, Nemoto K, Oriuchi N, Arai T, Asada T
  • Organizer: The Alzheimer's Association International Conference 2018
  • Int'l Joint Research
• [Presentation] Lighty rhythmic exercise increases frontal gyrus blood flow of elderly (2018)
  • Author(s): Oriuchi N, Tamura M, Nemoto K, Soya H, Asada T, Arai T
  • Organizer: The Alzheimer's Association International Conference 2018
  • Int'l Joint Research
• [Presentation] 認知症の行動・心理症状と脳血流の関連 (2018)
  • Author(s): 関根彩、中山顕次郎、塚田恵鯉子、太田深秀、東晋二、根本清貴、新井哲明
  • Organizer: 第37回日本認知症学会学術集会
• [Remarks] 第10回ABiS脳画像解析チュートリアル（アンケート結果）
  • URL: http://square.umin.ac.jp/bioimaging/tutorial_202112.html
• [Remarks] 動的プログラミング言語を知っている人のためのPython入門
  • URL: http://www.nemotos.net/resources/Brisk_Intro_Python_ja.html
• [Remarks] 第9回ABiS脳画像解析チュートリアル（アンケート結果）
  • URL: http://square.umin.ac.jp/bioimaging/tutorial_202101.html
• [Remarks] Matlab/VBM習得勉強会
  • URL: https://kytk.github.io/nisg-201912/
• [Remarks] FreeSurfer勉強会
  • URL: https://kytk.github.io/nisg-202001/
• [Remarks] Lin4Neuro
  • URL: https://www.nemotos.net/?page_id=161
• [Remarks] 脳画像のためのコマンドライン習得勉強会
  • URL: https://kytk.github.io/shell-basic/
• [Remarks] Lin4Neuroの配布ウェブサイト
  • URL: http://www.lin4neuro.net/lin4neuro/18.04bionic/