An evaluation of the effects of low-dose and low-dose-rate exposure on intestinal tumors by radiation mutation signatures

• Project/Area Number: 18K18197
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 63020:Radiation influence-related
• Research Institution: National Institutes for Quantum Science and Technology
• Principal Investigator: YANAGIHARA Hiromi 国立研究開発法人量子科学技術研究開発機構, 放射線医学研究所 放射線影響研究部, 研究員 (50719474)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 低線量率放射線 / 放射線発がん / Apc Minマウス / 放射線変異シグネチャー / LMD / Apc Min/+ マウス / Apc Min/+マウス / 低線量(率)放射線 / 消化管腫瘍 / Minマウス / 被爆時年齢依存性

Outline of Final Research Achievements

Carcinogenic risk of low-dose and low-dose-rate radiation exposure is unclear. In this study, we constructed the method to distinguish between radiation-induced and spontaneous tumors using genomic mutation patterns in a mouse model of intestinal carcinogenesis. As a result, it was possible to calculate the accurate frequency of radiation-induced tumors. This method is expected to contribute to the evaluation of accurate biological effects of low-dose and low-dose-rate radiation, especially carcinogenic risk.

Academic Significance and Societal Importance of the Research Achievements

低線量・低線量率放射線による影響は、急照射被ばくと比較して小さいことから正確なリスク評価が困難であるため、その影響評価法の構築が求められている。本研究では、放射線被ばくに起因する腫瘍を高精度に定量化可能な評価法を構築した。これにより、正確な低線量・低線量率放射線の影響と防護の対策の理解につながる科学的に新しい情報を提供することが期待される。

Research Products

• [Presentation] 放射線被ばくに起因する消化管腫瘍の評価法の確立 (2019)
  • Author(s): 柳原啓見, 山崎隼輔, 山田裕, 森岡孝満, 鶴岡千鶴, 甘崎佳子, 上西睦美, 遠坂歌子, 島田義也, 柿沼志津子
  • Organizer: 第56回アイソトープ・放射線研究発表会
• [Presentation] 消化管腫瘍モデルマウスを用いた放射線の被ばくに起因した腫瘍の評価 (2019)
  • Author(s): 柳原啓見, 山崎隼輔, 山田裕, 森岡孝満, 鶴岡千鶴, 甘崎佳子, 上西睦美, 遠坂歌子, 西村まゆみ, 島田義也, 柿沼志津子
  • Organizer: 第34回発癌病理研究会
• [Presentation] Development of a method for distinguishing radiation-induced and spontaneous intestinal tumors of C3B6F1 ApcMin/+ mice (2019)
  • Author(s): Yanagihara H, Yamazaki S, Yamada Y, Morioka T, Tsuruoka C, Amasaki Y, Kaminishi M, Enzaka U, Shimada Y, Kakinuma S
  • Organizer: 65th Annual Radiation Research Society Meeting
  • Int'l Joint Research
• [Presentation] Estimation of radiation-related cancer risk based on signature mutation using a murine model of intestinal neoplasia (2018)
  • Author(s): Hiromi Yanagihara, Shunsuke Yamazaki, Yutaka Yamada, Takamitsu Morioka, Chizuru Tsuruoka, Yoshiko Amasaki, Mutsumi Kaminishi, Utako Enzaka, Yoshiya Shimada, Shizuko Kakinuma
  • Organizer: the 64th Annual Radiation Research Society Meeting
  • Int'l Joint Research