Analysis of chemical exposure effects in human mothers and children through metabolomic analysis of body fluids and feces

• Project/Area Number: 18K18199
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 63030:Chemical substance influence on environment-related
• Research Institution: Chiba University
• Principal Investigator: Akifumi Eguchi 千葉大学, 予防医学センター, 助教 (70595826)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 残留性有機汚染物質 / 鉛 / メタボロミクス / コホート調査 / 複合曝露 / ポリ塩化ビフェニル / 重金属 / 出生コホート / DNAメチル化 / 金属 / 腸内細菌 / 鉛バッテリー

Outline of Final Research Achievements

In this study, we analyzed the effects of chemical exposure on human health by measuring the concentration and metabolomic composition of chemicals in samples obtained from a Japanese birth cohort and from a lead battery contaminated area in Vietnam.
In the Japanese birth cohort, it was suggested that exposure to polychlorinated biphenyls may be involved in the lowering of birth weight in children, but no clear relationship was found between the exposure and metabolome composition in serum and feces samples.
On the other hand, a relationship was found between lead exposure and urinary metabolome composition in lead battery contaminated areas, suggesting that lead may have adverse effects on human health through alterations in pathways related to central nervous system toxicity, nephrotoxicity, and heme biosynthesis.

Academic Significance and Societal Importance of the Research Achievements

本研究は、化学物質の曝露が健康影響に及ぶまでの間に、体内における代謝がどのように変化するかについて着目し、影響が現れるまでのメカニズムを明らかにしようとするものである。
毒性・健康影響発現までのメカニズムを明らかにすることができれば、影響が及ぶ前に介入などを試みることで、化学物質曝露による健康影響をを低減するための手法開発に結びつく可能性がある。

Research Products

• [Int'l Joint Research] New York University School of Medicine/New York State Department of Health(米国)
• [Int'l Joint Research] Kyung Hee University(韓国)
• [Int'l Joint Research] Vietnam National University(ベトナム)
• [Journal Article] Effects on the liver lipidome of rat offspring prenatally exposed to bisphenol A (2021)
  • Author(s): Nguyen Hoa Thanh、Li Lingyun、Eguchi Akifumi、Kannan Kurunthachalam、Kim Eun-Young、Iwata Hisato
  • Journal Title: Science of The Total Environment Volume: 759 Pages: 143466-143466
  • DOI: 10.1016/j.scitotenv.2020.143466
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls (2019)
  • Author(s): Eguchi Akifumi、Nishizawa-Jotaki Shino、Tanabe Hiromi、Rahmutulla Bahityar、Watanabe Masahiro、Miyaso Hidenobu、Todaka Emiko、Sakurai Kenichi、Kaneda Atsushi、Mori Chisato
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 16 Issue: 15 Pages: 2786-2786
  • DOI: 10.3390/ijerph16152786
  • Peer Reviewed / Open Access
• [Journal Article] Targeted metabolome analysis of the dog brain exposed to PCBs suggests inhibition of oxidative phosphorylation by hydroxylated PCBs (2019)
  • Author(s): Nomiyama K, Eguchi A, Takaguchi K, Yoo J, Mizukawa H, Oshihoi T, Tanabe S, Iwata H
  • Journal Title: Toxicology and Applied Pharmacology Volume: 377 Pages: 114620-114620
  • DOI: 10.1016/j.taap.2019.114620
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis. (2019)
  • Author(s): Dissanayake E, Inoue Y, Ochiai S, Eguchi A, Nakano T, Yamaide F, Hasegawa S, Kojima H, Suzuki H, Mori C, Kohno Y, Taniguchi M, Shimojo N
  • Journal Title: J Allergy Clin Immunol. Volume: Jan;143(1) Issue: 1 Pages: 447-450
  • DOI: 10.1016/j.jaci.2018.09.024
  • Peer Reviewed
• [Journal Article] The relationship of maternal PCB, toxic and essential trace element exposure levels with birth weight and head circumference in Chiba, Japan (2019)
  • Author(s): Akifumi Eguchi, Kana Yanase, Midori Yamamoto, Kenichi Sakurai, Masahiro Watanabe, Emiko Todaka, Chisato Mori
  • Journal Title: Environmental Science and Pollution Research Volume: - Issue: 15 Pages: 15677-15684
  • DOI: 10.1007/s11356-019-05009-0
  • Peer Reviewed
• [Journal Article] Alterations in urinary metabolomic profiles due to lead exposure from a lead?acid battery recycling site (2018)
  • Author(s): Eguchi Akifumi、Nomiyama Kei、Sakurai Kenichi、Kim Trang Pham Thi、Viet Pham Hung、Takahashi Shin、Iwata Hisato、Tanabe Shinsuke、Todaka Emiko、Mori Chisato
  • Journal Title: Environmental Pollution Volume: 242 Pages: 98-105
  • DOI: 10.1016/j.envpol.2018.06.071
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exploration of predictive metabolic factors for gestational diabetes mellitus in Japanese women using metabolomic analysis (2018)
  • Author(s): Sakurai Kenichi、Eguchi Akifumi、Watanabe Masahiro、Yamamoto Midori、Ishikawa Ko、Mori Chisato
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 2 Pages: 513-520
  • DOI: 10.1111/jdi.12887
  • Peer Reviewed / Open Access
• [Presentation] Association between levels of individual PCB congeners in maternal serum with birth weight of newborn in C-MACH study (2021)
  • Author(s): Akifumi Eguchi, Kenichi Sakurai, Midori Yamamoto, Masahiro Watanabe, Aya Hisada, Tomoko Takahashi, Emiko Todaka, Chisato Mori
  • Organizer: SOT Annual Meeting
  • Int'l Joint Research
• [Presentation] Alterations in profiles of metabolome and gut-microbiome due to lead exposure PCBs and p, p’-DDE in C-MACH cohort (2019)
  • Author(s): Akifumi Eguchi, Kenichi Sakurai, Tamotsu Kato, Yumiko Nakanishi, Hiromi Tanabe, Yumi Sato, Midori Yamamoto, MasahiroWatanabe, Hiroshi Ohno, Chisato Mori
  • Organizer: Society of Toxicology 58th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Relationship between metabolome and gut-microbiome profiles and exposure levels of PCBs and p, p’-DDE in C-MACH cohort (2018)
  • Author(s): Akifumi Eguchi, Kenichi Sakurai, Tamotsu Kato, Yumiko Nakanishi, Hiromi Tanabe, Yumi Sato, Midori Yamamoto, MasahiroWatanabe, Hiroshi Ohno, Chisato Mori
  • Organizer: 第21回環境ホルモン学会研究発表会
• [Remarks] Researchgate
  • URL: https://www.researchgate.net/profile/Akifumi-Eguchi
• [Remarks] Google Scholar
  • URL: https://scholar.google.com/citations?user=in2FlHwAAAAJ
• [Remarks]
  • URL: https://researchmap.jp/siero5335
• [Remarks]
  • URL: https://scholar.google.com/citations?user=in2FlHwAAAAJ
• [Remarks] Researchgate
  • URL: https://www.researchgate.net/profile/Akifumi_Eguchi
• [Remarks] Researchmap
  • URL: https://researchmap.jp/siero5335/
• [Remarks] Google scholar
  • URL: http://scholar.google.com/citations?user=in2FlHwAAAAJ