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Development of a synthetic method and investigation of bioaccumulation for halogenated polycyclic aromatic hydrocarbons

Research Project

Project/Area Number 18K18208
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 64010:Environmental load and risk assessment-related
Research InstitutionUniversity of Shizuoka

Principal Investigator

Wang Qi  静岡県立大学, 食品栄養科学部, 特任助教 (60811685)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsハロゲン化多環芳香族炭化水素類(XPAHs) / 標準物質 / XPAHsの分析方法 / 生物蓄積性 / 環境残留性 / 汚染実態 / ハロゲン化多環芳香族炭化水素類 / PAHs誘導体 / 標準合成 / ハロゲン化多環芳香族炭化水素(XPAHs) / XPAHsの水酸化体 / 新規合成 / 生体曝露
Outline of Final Research Achievements

We synthesized the analytical standards of halogenated polycyclic aromatic hydrocarbons (XPAHs) including tri-Chloropyrene and tetra-Chloropyrene, which are environmental pollutants with high potential risk. The concentrations of 26 XPAHs in sediment and fish samples collected from Tokyo bay were measured. To investigate the bioaccumulation potential of XPAHs, the biota-sediment accumulation factors (BSAFs) were calculated by the XPAH concentrations in fish (lipid weight) and sediment (organic carbon weight) samples.

Academic Significance and Societal Importance of the Research Achievements

本研究にて新規合成した標準物質を活用することで、ハロゲン化多環芳香族炭化水素類(XPAHs)の汚染実態や環境挙動、毒性などに関して、今後、より高度な研究を推進することが可能となる。また、本研究の結果より、今まで明らかにされていなかったXPAHsの生物蓄積性に関する情報を補填し、一定の知見を得ることができた。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (40 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (37 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results)

  • [Journal Article] Quantification of Brominated Polycyclic Aromatic Hydrocarbons in Environmental Samples by Liquid Chromatography Tandem Mass Spectrometry with Atmospheric Pressure Photoionization and Post-column Infusion of Dopant2020

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Journal Title

      Analytical Sciences

      Volume: 36 Issue: 9 Pages: 1105-1111

    • DOI

      10.2116/analsci.20P025

    • NAID

      130007898810

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2020-09-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk assessment of polycyclic aromatic hydrocarbons and their chlorinated derivatives produced during cooking and released in exhaust gas2020

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 197 Pages: 110592-110592

    • DOI

      10.1016/j.ecoenv.2020.110592

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simultaneous determination of polycyclic aromatic hydrocarbons and their chlorinated derivatives in grilled foods2019

    • Author(s)
      Masuda Misato、Wang Qi、Tokumura Masahiro、Miyake Yuichi、Amagai Takashi
    • Journal Title

      Ecotoxicology and Environmental Safety

      Volume: 178 Pages: 188-194

    • DOI

      10.1016/j.ecoenv.2019.04.046

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] A reduction method of PAH concentration in dried bonito2019

    • Author(s)
      K. Sei, M. Masuda, Q. Wang, M. Tokumura, Y. Miyake, T. Takagi, S. Suzuki, T. AmagaiK. Okamoto,
    • Organizer
      THE 24th Shizuoka Forum on Health and Longevity
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accumulation Profiles of Chlorinated Polycyclic Aromatic Hydrocarbons in Tokyo Bay in Japan2019

    • Author(s)
      M. Masuda, Q. Wang, M. Tokumura, Y. Miyake, T. Amagai, Y. Horii
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Comprehensive Analytical Method for Regulated Polucyclic Aromtic Hydrocarbons2019

    • Author(s)
      K. Sei, Q. Wang, M. Masuda, M. Tokumura, Y. Miyake, T. Amagai
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis and hAhRα Activity Assay of Metabolites of Chlorinated Polycyclic Aromatic Hydrocarbons2019

    • Author(s)
      T. Tada, A. Amano, K. Sei, Q. Wang, M. Tokumura, Y. Miyake, T. Amagai, M. Makino
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Brominated and Organophosphate Flame Retardants Detected in House Dust2019

    • Author(s)
      Q. Wang, M. Furukawa, M. Tokumura, Y. Miyake, T. Amagai, M. Makino
    • Organizer
      39th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Risk Assessment of Polycyclic Aromatic Hydrocarbons and their Chlorinated Derivatives Unintentionally Produced During Cooking via Exhaust Gas2019

    • Author(s)
      M. Masuda, Q. Wang, M. Tokumura, Y. Miyake, T. Amagai
    • Organizer
      the International Society of Exposure Science (ISES) and the International Society of Indoor Air Quality and Climate (ISIAQ) 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accumulation Profiles of Chlorinated Polycyclic Aromatic Hydrocarbons in Tokyo Bay, Japan2019

    • Author(s)
      M. Masuda, Q. Wang, M. Tokumura, Y. Miyake, T. Amagai
    • Organizer
      The Water and Environment Technology Conference 2019 (WET 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 調理により生成する多環芳香族炭化水素類のリスク評価と削減策の検討2019

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      2019年室内環境学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハウスダスト中の多環芳香族炭化水素類及びそのハロゲン誘導体の網羅的実態調査2019

    • Author(s)
      清 健人, 久米 一成, 王 斉, 甲斐 葉子, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      2019年室内環境学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 一般住宅におけるハウスダスト中のリン系難燃剤の濃度と組成実態調査2019

    • Author(s)
      王 斉, 久米 一成, 清 健人, 増田 美里, 三輪 春樹, 甲斐 葉子, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      2019年室内環境学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 生体内での代謝を考慮した有害物質の新規合成と生態毒性評価2019

    • Author(s)
      多田 智彦, 天野 あすか, 清 健人, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史, 牧野 正和
    • Organizer
      富士山麓A&Sフェア2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 健康に考慮したかつお節製造法の検討2019

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 髙木 毅, 鈴木 進二, 岡本 一利, 雨谷 敬史
    • Organizer
      富士山麓A&Sフェア2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肉の加熱調理による発がん性物質(多環芳香族炭化水素類)の生成2019

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      富士山麓A&Sフェア2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 塩素化多環芳香族炭化水素類の代謝を考慮した有害性評価2019

    • Author(s)
      多田 智彦, 天野 あすか, 清 健人, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史, 牧野 正和
    • Organizer
      環境科学会2019年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] かつお節中の多環芳香族炭化水素 (PAH) 濃度低減に向けた製造法の提案2019

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 雨谷 敬史, 髙木 毅, 鈴木 進二, 岡本 一利
    • Organizer
      環境科学会2019年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食品の加熱調理による多環芳香族炭化水素とその塩素化体の生成と曝露評価2019

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      環境科学会2019年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 塩素化多環芳香族炭化水素類の代謝生成物の新規合成とhAhRα活性評価2019

    • Author(s)
      多田 智彦, 天野 あすか, 清 健人, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史, 牧野 正和
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 魚試料中のPAHsおよびハロゲン化PAHsのヒドロキシ誘導体の分析方法に関する検討2019

    • Author(s)
      王 斉, 増田 美里, 天野 あすか, 清 健人, 多田 智彦, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 規制対象の多環芳香族炭化水素類 (PAHs) に対応した網羅的分析法の開発2019

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LC-APPI-MS/MSを用いた環境サンプル中臭素化多環芳香族炭化水素の分析法の検討2019

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 底質・魚介類中のハロゲン化多環芳香族炭化水素の汚染実態調査2019

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      第53回日本水環境学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Emission and mass balance of halogenated polycyclic aromatic hydrocarbons from waste incinerator2018

    • Author(s)
      Qi Wang, Yuichi Miyake, Masahiro Tokumura, Takashi Amagai, Yuichi Horii, Kiyoshi Nojiri, Nobutoshi Ohtsuka
    • Organizer
      The 13th Japan-China International Symposium on Health Sciences
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Environmental impact of halogenated polycyclic aromatic hydrocarbons emitted from E-waste recycling activities in Vietnam2018

    • Author(s)
      Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      The 12th Asia Impact Assessment Conference (AIC2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Generation of polycyclic aromatic hydrocarbons and their derivatives during cooking2018

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      The 4th International Conference on Pharma and Food (ICPF2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Risk assessment of polycyclic aromatic hydrocarbons and their chlorinated derivatives produced by cooking2018

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      THE 23rd Shizuoka Forum on Health and Longevity
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] An Analytical Method for Chlorinated Polycyclic Aromatic Hydrocarbons in Particles by Thermal Desorption-GC/MS2018

    • Author(s)
      Kento Sei, Qi Wang, Misato Masuda, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      Dioxin 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Unintentional Generation of Chlorinated Polycyclic Aromatic Hydrocarbons during Cooking2018

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      Dioxin 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Determination of Chlorinated Polycyclic Aromatic Hydrocarbons in Sediments2018

    • Author(s)
      Misato Masuda, Qi Wang, Masahiro Tokumura, Yuichi Miyake, Takashi Amagai
    • Organizer
      The Water and Environment Technology Conference 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 加熱脱着法を用いた塩素化多環芳香族炭化水素類 (ClPAHs) の室内濃度の実態調査2018

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      平成30年室内環境学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 加熱調理により生成した多環芳香族炭化水素とその塩素化体の曝露経路別リスク評価2018

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      平成30年室内環境学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 活性炭・シリカゲルチューブを用いた作業環境における揮発性有機化合物の回収率に関する検討2018

    • Author(s)
      王斉,徳村雅弘,三宅祐一,雨谷敬史,福島靖弘,鈴木義浩,榎本孝紀
    • Organizer
      平成30年室内環境学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食品や調理排気中に存在する多環芳香族炭化水素誘導体のリスク評価2018

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      富士山麓A&Sフェア2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 発がん物質生成に対する室内暖房の寄与2018

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      富士山麓A&Sフェア2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 塩素化多環芳香族炭化水素類 (ClPAHs) 個人曝露評価のための高感度分析法の開発2018

    • Author(s)
      清 健人, 王 斉, 増田 美里, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      環境科学会 2018年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 調理により生成する多環芳香族炭化水素とその塩素化体の経路別曝露量の比較2018

    • Author(s)
      増田 美里, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      環境科学会 2018年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規環境汚染物質である塩素化多環芳香族炭化水素類の包括的かつ統合的環境影響評価2018

    • Author(s)
      天野 あすか, 五老 祐大, 徳村 雅弘, 王 斉, 内藤 博敬, 三宅 祐一, 雨谷 敬史, 牧野 正和
    • Organizer
      環境科学会 2018年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 加熱脱着-GC/MSを用いた粒子状塩素化多環芳香族炭化水素類(ClPAHs)分析法の開発2018

    • Author(s)
      清 健人, 王 斉, 徳村 雅弘, 三宅 祐一, 雨谷 敬史
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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