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CFD analysis on MR enhanced wall for investigation of mechanism of aneurysm instabiity

Research Project

Project/Area Number 18K18355
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionTohoku University

Principal Investigator

ANZAI HITOMI  東北大学, 流体科学研究所, 助教 (50736981)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳動脈瘤 / MR血管造影 / ディープラーニング / 数値流体力学解析 / 深層学習 / 脳動脈 / 冠動脈 / 大動脈 / 数値流体力学 / 造影MRI / 数値流体解析 / 血管造影MR / MRI
Outline of Final Research Achievements

This study aims to correlate the wall enhancement in MR vessel wall imaging and hemodynamic stress in small-middle cerebral aneurysms. In the case of 10-years follow-up, the extension of aneurysm wall occurs near the breb where the wall enhancement observed.
For further study to establish the threshold of hemodynamic parameters, analysis for big data will be required. Therefore, deep learning technique was applied for predicting the flow field inside blood vessels. This network can predict the flow from the geometry directly and achieved the speedup of analysis 600 times than conventional CFD.

Academic Significance and Societal Importance of the Research Achievements

脳動脈瘤は人口の3-5%に発生し、1%/年で破裂の可能性を持つ。しかし破裂メカニズムは不明なことも多く、未だ破裂の予測は難しい。本研究では破裂の前段階に存在すると考えられている動脈瘤壁の炎症と血流分布を照らし合わせ、血流ストレスが壁面の縮退に与える影響を調べることで、動脈瘤の成長メカニズムの解明に貢献した。さらに、疫学的エビデンスを得るためには大規模な患者群に対する解析が不可欠であることから、深層学習ネットワークの構築により血流解析を即時化し、大規模な患者群への血流解析を可能とした。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (42 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (27 results) (of which Int'l Joint Research: 21 results,  Invited: 4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] 北京工科大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ヒースランデン病院(スイス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Hirslanden Hospital/ZHAW(スイス)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Prediction of 3D Cardiovascular hemodynamics before and after coronary artery bypass surgery via deep learning2021

    • Author(s)
      Li Gaoyang、Wang Haoran、Zhang Mingzi、Tupin Simon、Qiao Aike、Liu Youjun、Ohta Makoto、Anzai Hitomi
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s42003-020-01638-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Hemodynamic-Based Evaluation of Applying Different Types of Coronary Artery Bypass Grafts to Coronary Artery Aneurysms2020

    • Author(s)
      Wang Haoran、Anzai Hitomi、Liu Youjun、Qiao Aike、Xie Jinsheng、Ohta Makoto
    • Journal Title

      Complexity

      Volume: 2020 Pages: 1-10

    • DOI

      10.1155/2020/9359340

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implementation of computer simulation to assess flow diversion treatment outcomes: Systematic review and meta-analysis2020

    • Author(s)
      Zhang Mingzi、Tupin Simon、Anzai Hitomi、Kohata Yutaro、Shojima Masaaki、Suzuki Kosuke、Okamoto Yoshihiro、Tanaka Katsuhiro、Yagi Takanobu、Fujimura Soichiro、Ohta Makoto
    • Journal Title

      Journal of NeuroInterventional Surgery

      Volume: 13 Issue: 2 Pages: 164

    • DOI

      10.1136/neurintsurg-2020-016724

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemodynamic-Based Evaluation on Thrombosis Risk of Fusiform Coronary Artery Aneurysms Using Computational Fluid Dynamic Simulation Method2020

    • Author(s)
      Wang Haoran、Anzai Hitomi、Liu Youjun、Qiao Aike、Xie Jinsheng、Ohta Makoto
    • Journal Title

      Complexity

      Volume: 2020 Pages: 1-11

    • DOI

      10.1155/2020/8507273

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulse-Wave-Pattern Classification with a Convolutional Neural Network2019

    • Author(s)
      Li Gaoyang、Watanabe Kazuhiro、Anzai Hitomi、Song Xiaorui、Qiao Aike、Ohta Makoto
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 14930-14930

    • DOI

      10.1038/s41598-019-51334-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Relationship Between the Arterial Geometry and Wall Shear Stress in the Vertebrobasilar System2019

    • Author(s)
      Pan Fangjia、Anzai Hitomi、Mugikura Shunji、Kitamura Ko、Ohta Makoto
    • Journal Title

      Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition

      Volume: 3

    • DOI

      10.1115/imece2019-10866

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of Input Image Configurations on Output of a Convolutional Neural Network to Detect Cerebral Aneurysms2019

    • Author(s)
      Watanabe Kazuhiro、Anzai Hitomi、Juchler Norman、Hirsch Sven、Bijlenga Philippe、Ohta Makoto
    • Journal Title

      Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition

      Volume: 3

    • DOI

      10.1115/imece2019-11125

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systematic review of hemodynamic discriminators for ruptured intracranial aneurysms2019

    • Author(s)
      Yagi Takanobu、Ishida Fujimaro、Shojima Masaaki、Anzai Hitomi、Fujimura Souichiro、Sano Takanori、Shinozaki Shun、Yamanaka Yuuma、Yamamoto Yuuto、Okamoto Yoshihiro、Ohta Makoto、Nakamura Masanori、on behalf of the CFD-BIO study group
    • Journal Title

      Journal of Biorheology

      Volume: 33 Issue: 2 Pages: 53-64

    • DOI

      10.17106/jbr.33.53

    • NAID

      130007777456

    • ISSN
      1867-0466, 1867-0474
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial cell distributions and migration under conditions of flow shear stress around a stent wire2019

    • Author(s)
      Anzai Hitomi、Watanabe Tomohito、Han Xiaobo、Putra Narendra Kurnia、Wang Zi、Kobayashi Hisatoshi、Ohta Makoto
    • Journal Title

      Technology and Health Care

      Volume: Online ahead of print Issue: 4 Pages: 1-10

    • DOI

      10.3233/thc-191911

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiobjective design optimization of stent geometry with wall deformation for triangular and rectangular struts2018

    • Author(s)
      Putra Narendra Kurnia、Palar Pramudita Satria、Anzai Hitomi、Shimoyama Koji、Ohta Makoto
    • Journal Title

      Medical & Biological Engineering & Computing

      Volume: 57 Issue: 1 Pages: 15-26

    • DOI

      10.1007/s11517-018-1864-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] CFD Analysis of The Effect of Flush Flow Condition on Angiopscopy Visibility2020

    • Author(s)
      Kohei Mitsuzuka, Yujie Li, Toshio Nakayama, Hitomi Anzai, Wang Haoran, Makoto Ohta, Simon Tupin
    • Organizer
      17th International Conference on Flow Dynamics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Implementation of Computer Simulation to Assess Flow-Diversion Treatment Outcomes; Systematic Review and Meta-Analysis2020

    • Author(s)
      Mingzi Zhang, Simon Tupin, Hitomi Anzai, Yutaro Kohata, Massaki Shojima, Kosuke Suzuki, Yoshihiro Okamoto, Katsuhiro Tanaka, Takanobu Yagi, Soichiro Fujimura, Makoto Ohta
    • Organizer
      17th Interdisciplinary Cerebrovascular Symposium (ICS 2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimization of stent structure based on blood flow simulation2020

    • Author(s)
      Hitomi Anzai, Mingzi Zhang, Narendra Kurnia Putra, Makoto Ohta
    • Organizer
      2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体組織モデルを用いた医療機器開発へ参加のお誘い2020

    • Author(s)
      太田 信,Tupin Simon,安西 眸,于 凱鴻,Zhang Mingzi,戸塚 厚,小助川博之
    • Organizer
      第61回 日本脈管学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] CFD analysis of AVF for hemodialysis2020

    • Author(s)
      Kazuki Takeda, Hitomi Anzai, Mingzi Zhang, Kohei Mitsuzuka, Wang Haoran, Ai Kajiyama, Makoto Ohta
    • Organizer
      2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The influence brought by specific boundary conditions on vascular simulations2020

    • Author(s)
      Fangjia Pan, Makoto Ohta , Hitomi Anzai, Shunji Mugikura, Naoko Mori
    • Organizer
      2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A study on Optical Flow Method for Hemodynamics Estimation2020

    • Author(s)
      Yutaro Kohata, Hitomi Anzai, Makoto Ohta, Meghane Decroocq, Carole Frindel, Simon RIT
    • Organizer
      2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Angiography-based velocimetry for blood flow2020

    • Author(s)
      Y. Kohata, H. Anzai, M. Decroocq, S. Rit, C. Frindel, M. Ohta
    • Organizer
      Lyon Saint Etienne & Nippon Scientific Network Engineering sciences Lyon Tohoku Lyon; ELyT Workshop 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D Structure Standardization Of Cerebral Artery Using MRA Images For Classificattion2019

    • Author(s)
      Ko Kitamura, Shunji Mugikura, Makoto Ohta, Hitomi Anzai
    • Organizer
      6th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computational Fluid Dynamics Analysis of Pial Arteriovenous Fistula2019

    • Author(s)
      Yutaro Kohata, Anzai Hitomi, Taichi Kin, Ohta Makoto
    • Organizer
      6th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRA 画像を用いた脳底動脈形状の標準化2019

    • Author(s)
      北村洸,麦倉俊司,太田信,安西眸
    • Organizer
      第30回バイオフロンティア講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] Physical and Virtual Arterial Models with Mechanical Properties for Mechanical Testing of Medical Device2019

    • Author(s)
      Makoto Ohta, Yasutomo Shimizu, Kaihong Yu, Mingzi Zhang, Simon Tupin, Hitomi Anzai
    • Organizer
      UTM-IFS 1st Workshop 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulse pattern classification of atherosclerotic patients based on convolutional neural network2019

    • Author(s)
      Gaoyang Li, Hitomi Anzai, Makoto Ohta
    • Organizer
      UTM-IFS 1st Workshop 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of Input Patch Sizes on Results of a Convolutional Neural Network to Detect Cerebral Aneurysms from MRA Images2019

    • Author(s)
      Kazuhiro Watanabe, Hitomi Anzai, Norman Juchler, Sven Hirsch, Philippe Bijlenga, Makoto Ohta
    • Organizer
      Sixteenth International Conference on Flow Dynamics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Flow Characteristics of Wall Elasticity in a Full-Scale patient-Specific Middle Cerebral Aneurysm2019

    • Author(s)
      Gaku Tanaka, Nadia S. Shafii, Gaku Takizawa, Tomoaki Yamazaki, Simon Tupin, Hitomi Anzai, Kahar Osman, Ryuhei Yamaguchi, and Makoto Ohta
    • Organizer
      The Nineteenth International Symposium on Advanced Fluid Information (AFI-2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiobjective Optimization of Stent Design towards In-Stent Restenosis2018

    • Author(s)
      Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Can morphology or haemodynamic characteristics of verteebrobasilar system be identifier of hypertension2018

    • Author(s)
      Ko Kitamura, Yujie Li, Mingzi Zhang, Hitomi Anzai, Shuji Mugikura, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characteristics of Elasticity on Flow Behavior in Middle Cerebral Aneurysm Model2018

    • Author(s)
      Ryuhei Yamaguchi, Gaku Tanaka, Taihei Kotani, Kahar Osman, Nadia Shafii, Hitomi Anzai, Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dose hypertension history affect morphology or hemodynamic characteristics of ertebrobasilar system? Retrospective study of 249 patients dagnosed with hypertension2018

    • Author(s)
      Yujie Li, Mingzi Zhang, Ko Kitamura, Hitomi anzai, Shuji Mugikura, and Makoto Ohta
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computational Fluid Dynamics Analysis to Predict Endothelial Cells Migration during Flow Exposure Experiment with Placement of Two Stent Wires2018

    • Author(s)
      Narendra Kurnia Putra, Zi Wang, Hitomi Anzai, Makoto Ohta
    • Organizer
      40th Annual International Conference of IEEE Engineering in Medicine and Biology Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] PIV MEASUREMENT IN AN IDEAL ANEURYSMAL MODEL USING A TRANSPARENT COIL MODEL2018

    • Author(s)
      Makoto OHTA, Masanori KUZE, Simon TUPIN, Kaihong YU, Yasutomo SHIMIZU, Hitomi ANZAI
    • Organizer
      Conference on Modelling Fluid Flow (CMFF’18) The 17th International Conference on Fluid Flow Technologies
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hemodynamic Study on Coronary Artery Aneurysms with Bypass Surgery2018

    • Author(s)
      Haoran Wang, Hitomi Anzai, Makoto Ohta, Youjun Liu
    • Organizer
      ICFD (Internatinal Conference of Fluid Dynamics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulation research on hemodynamic of surgery of coronary artery aneurysm2018

    • Author(s)
      Haoran Wang, Hitomi Anzai, Youjun Liu, Ohta Makoto
    • Organizer
      日本機械学会2018年度年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 畳み込みニューラルネットワークに基づくアテローム性動脈硬化症患者のパルスパターン認識2018

    • Author(s)
      Gaoyang Li, Hitomi Anzai, Kazuhiro Watanabe, Aike Qiao, Xiaorui Song, Makoto Ohta
    • Organizer
      第29回バイオフロンティア講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脳動脈瘤抽出用ニューラルネットワークにおける,入力画像の表現方法の違いによる判定精度への影響2018

    • Author(s)
      渡邉和浩, 安西眸, Norman Juchler, Sven Hirsch, Philippe Bijlenga, 太田信
    • Organizer
      第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] An application of deep learning technique for neurovascular research and future diagnosis2018

    • Author(s)
      Hitomi Anzai
    • Organizer
      15th Interdisciplinary Cerebrovascular Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 格子ボルツマン法を用いたステントストラット配置が脳動脈瘤流れに与える影響の解析2018

    • Author(s)
      渡邉和浩, 安西眸, 太田信
    • Organizer
      第23回計算工学講演会
    • Related Report
      2018 Research-status Report
  • [Remarks] 東北大学流体科学研究所 太田研究室

    • URL

      http://www.ifs.tohoku.ac.jp/bfc/

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 血流場推定装置、学習装置、血流場推定方法及びプログラム2020

    • Inventor(s)
      安西眸
    • Industrial Property Rights Holder
      安西眸
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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