| Project/Area Number |
18K18358
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Shima Ai 東京大学, 大学院情報理工学系研究科, 特任助教 (50757309)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / 細胞・組織 / 発生・分化 / 組織工学 |
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| Outline of Final Research Achievements |
It is becoming more and more important in Japan, where the super-aging society has arrived, to maintain the health of the locomotorium including muscles and tendons. Therefore, the purpose of this study was to construct a three-dimensional skeletal muscle tissue model with tendon cells. As a result of examining the co-culture conditions of human tenocytes and human myocytes, spontaneous muscle contraction was achieved in the fiber-shaped three-dimensional muscle tissue in which tendon cells are arranged at both ends. Moreover, the interaction of each type of cells during the co-culture was studied. This model is expected to become a tool for investigating the interaction between tendon and muscle in the future.
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| Academic Significance and Societal Importance of the Research Achievements |
薬剤の開発や疾患の治療法確立のためには、生体を模倣したヒト組織モデルが必要である。特に、運動器の健康増進に貢献するモデルは、超高齢化社会を迎えた我が国において価値が高いと考える。近年、３次元組織培養技術の発達により、生体に近い組織を体外で構築することが可能になっているが、機能的なヒト腱-筋モデルは未だ存在していない。本研究では、腱-筋モデル構築の端緒となる腱細胞と筋細胞の３次元的共培養に着手している点に学術・社会的意義が認められる。
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