Development of smart biodevices for quick and simple counting of disease-related bacteria
| Project/Area Number |
18K18361
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tabata Miyuki 東京医科歯科大学, 生体材料工学研究所, テニュアトラック助教 (00636839)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | バイオセンサ / 細菌 |
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| Outline of Final Research Achievements |
To develop a small-sized diagnostic device for electrochemically detecting disease-related bacteria and to develop a bacterial counting system that enables in-situ diagnosis in clinical medicine, the sensor electrodes having the same size as the bacteria were integrated with the microfabrication technology. The bacteria-specific antibodies were immobilized on the sensor surface, and then the target bacteria was electrochemically detected.
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| Academic Significance and Societal Importance of the Research Achievements |
細菌検出技術は医療、生命科学、食品、環境など、幅広い分野において必要不可欠な技術である。細菌同定技術は開発から30年以上経過しているPolymerase chain reaction (PCR)に依存しているのが現状で、新たな検出原理の探求が滞っている。本研究では、微細センサの作りこみによる構造最適化と特異検出を実現する機能化センサ表面の構築の両方からアプローチするという新しい方法論により、高速細菌検出を検討することに学術的意義がある。
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Report
(3 results)
Research Products
(19 results)
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[Presentation] Development of the wireless pH sensor for quantitative analysis in dental field2018
Author(s)
Chindanai Ratanaporncharoen, Miyuki Tabata, Noboru Ishihara, Kazuya Masu, Mana Sriyudthsak, Yuichi Kitasako, Masaomi Ikeda, Junji Tagami, Tatsuro Goda, Akira Matsumoto, Yuji Miyahara
Organizer
The 3rd International Symposium on Biomedical Engineering, Hiroshima University, Higashi-Hiroshima
Related Report
Int'l Joint Research
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[Presentation] Application of solid-state electrochemical sensors for quantitative analysis in dental field2018
Author(s)
Chindanai Ratanaporncharoen, Miyuki Tabata, Noboru Ishihara, Kazuya Masu, Mana Sriyudthsak, Yuichi Kitasako, Masaomi Ikeda, Junji Tagami, Tatsuro Goda, Akira Matsumoto, Yuji Miyahara
Organizer
Frontiers2018" - EPFL/TMDU/UTokyo Symposium
Related Report
Int'l Joint Research
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