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Fabrication of pseudo-cellular materials to avoid immune responses in vivo

Research Project

Project/Area Number 18K18381
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionThe University of Tokyo

Principal Investigator

Oda Haruka  東京大学, 大学院情報理工学系研究科, 特任助教 (30784508)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsハイドロゲル / 粒子 / 生体材料 / 微粒子
Outline of Final Research Achievements

A pseudo-cellular material to avoid the immune response was proposed. This pseudo-cellular material is considered to have a morphology, viscoelasticity and surface structure similar to that of a cell. We have tried to make them. For this purpose, polymer particles were fabricated using a microfluidic device and furthermore, the particles Surface modification of the microfluidic device was efficiently fabricated by surface modification The surface of the polymer particles was modified. We found that the cells responded differently to the fabricated pseudo-cellular materials depending on their viscoelasticity. Also the particle was compounded with the strong polymer materials for long-term implantable strength. This leads to long-term stable implantable materials.

Academic Significance and Societal Importance of the Research Achievements

人工材料を生体内に移植することで失われた生体機能を代替しようとする試みは多く行われている。しかし、移植された物質は生体の免疫反応により本来期待された機能を発揮できないことが多い。そこで本研究では細胞と材料との相互作用を理解し制御することを可能とする材料を提示することを目的とする。これを達成することで免疫反応の理解の一端となるとともに長期に移植可能な材料設計を提示することができると考える。広く適用可能な移植用材料は多くの医療分野へ貢献することができる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019

All Presentation (2 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Presentation] PDMS Bonding Without O2 Plasma Treatment2019

    • Author(s)
      Haruka Oda and Shoji Takeuchi
    • Organizer
      The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tough hydrogel tube for long-term cellular graft2019

    • Author(s)
      H.Oda, S. Nagata, S. Takeuchi
    • Organizer
      MEMS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] Surface modification of PDMS for O2 plasma free bonding2019

    • Inventor(s)
      Haruka Oda, Shoji Takeuchi
    • Industrial Property Rights Holder
      Haruka Oda, Shoji Takeuchi
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2021-02-19  

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