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Development of an ultrasonic measurement system with high temporal resolution for an estimation of three-dimensional blood flow velocity vectors in a left ventricle of heart

Research Project

Project/Area Number 18K18395
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90130:Medical systems-related
Research InstitutionUniversity of Toyama

Principal Investigator

Nagaoka Ryo  富山大学, 学術研究部工学系, 助教 (60781648)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords超音波計測 / 血流情報 / 高時間分解能 / 血流推定法 / 1.5D超音波アレイプローブ / 2次元血流推定法 / 3次元スペックルトラッキング法 / ベクトルフローマッピング法 / スペックルトラッキング法 / 3次元血流ベクトル計測 / 1.5次元アレイプローブ
Outline of Final Research Achievements

To prevent heart failure, a function of heart playing a role as a pump, which sends blood to whole body, is needed to be evaluated quantitatively and the blood flow dynamics include much more important information for diagnosis. Especially, it’s known that the flow information in the left ventricle of heart is closely related to the heart failure. In this study, we designed and developed a 1.5-D ultrasonic array probe to achieve measurement of three-dimensional blood flow velocity vectors in the left ventricle. Also, we proposed an estimation method of the blood flow velocity vectors and evaluated it by performing simulation and in vivo experiments.

Academic Significance and Societal Importance of the Research Achievements

1.5D超音波アレイプローブの使用と広く普及している超音波診断装置のソフトウェアを改良することによって, 臨床の現場でも左心室内の血流速度ベクトル情報を高時間分解能で計測可能となり, 国民の生活の質の向上にも大いに貢献することが期待出来る. さらに, 本研究は血流だけではなく, 血管壁や心臓壁のダイナミクス解明にも応用可能であり, それらの動態も定量的に評価可能となることが期待出来る.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results) Presentation (19 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Effects from correction of speed of sound in transmit and receive beamforming using focus beam2021

    • Author(s)
      Ryo Nagaoka, Shin Yoshizawa, Shin-ichiro Umemura, Hideyuki Hasegawa
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic study on estimation method of wall shear stress in common carotid artery using blood flow imaging2020

    • Author(s)
      Ryo Nagaoka, Kazuma Ishikawa, Michiya Mozumi, Magnus Cinthio, Hideyuki Hasegawa
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Modified high-resolution wavenumber analysis for detection of pulse wave velocity using coefficient of variation of arterial wall acceleration waveforms.2020

    • Author(s)
      Ryo Nagaoka, Hideyuki Hasegawa
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: - Issue: 2 Pages: 167-177

    • DOI

      10.1007/s10396-019-00998-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of vascular lumen by singular value decomposition filtering on blood flow velocity distribution2019

    • Author(s)
      Nagaoka Ryo、Hasegawa Hideyuki
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 46 Issue: 2 Pages: 187-194

    • DOI

      10.1007/s10396-019-00928-4

    • NAID

      130007967683

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigation on estimation accuracy of 2-Step block matching methods using envelope and RF signals for 2-D blood2019

    • Author(s)
      Ryo Nagaoka, Michiya Mozumi, Hideyuki Hasegawa
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 印刷中

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utilization of singular value decomposition in high-frame-rate cardiac blood flow imaging2019

    • Author(s)
      Michiya Mozumi, Ryo Nagaoka, Hideyuki Hasegawa
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 印刷中

    • NAID

      210000156364

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Visualization of micro flow channel by plane wave imaging and temporal variance2020

    • Author(s)
      Ryo Nagaoka, Benjamin Meirza, Maria Evertsson, Magnus Cinthio, Hideyuki Hasegawa
    • Organizer
      IEEE 2020 International Ultrasonics Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 特異値分解および時間的分散を用いた微小血管の可視化に関する基礎検討2020

    • Author(s)
      長岡 亮、長谷川英之
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Basic study on correction of speed of sound in forming of non-cylindrical focus beam2020

    • Author(s)
      Ryo Nagaoka, Shin Yoshizawa, Shin-ichiro Umemura, Hideyuki Hasegawa
    • Organizer
      The 41st Symposium on Ultrasonic Electronics
    • Related Report
      2020 Annual Research Report
  • [Presentation] Visualization of blood flow velocity vectors in human heart using high frame rate ultrasound imaging and vector flow mapping2019

    • Author(s)
      Ryo Nagaoka, Michiya Mozumi, and Hideyuki Hasegawa
    • Organizer
      IEEE International Ultrasonics Symposium 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 超高時間分解能ベクトルフローマッピング法による心臓内血流ダイナミクスと2次元速度情報の評価2019

    • Author(s)
      長岡 亮, 茂澄倫也, 長谷川英之
    • Organizer
      第13回血流会
    • Related Report
      2019 Research-status Report
  • [Presentation] Basic study on estimation method of shear stress in carotid artery using blood flow imaging2019

    • Author(s)
      Ryo Nagaoka, Kazuma Ishikawa, Michiya Mozumi, Magnus Cinthio, and Hideyuki Hasegawa
    • Organizer
      The 40th Symposium on Ultrasonic Electronics
    • Related Report
      2019 Research-status Report
  • [Presentation] 超高速超音波断層法による左心室内血流動態の可視化2019

    • Author(s)
      長岡 亮,茂澄倫也,石川数馬,長谷川英之
    • Organizer
      日本超音波医学会第40回中部地方会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高時間分解能超音波イメージングを用いた血球の粒子サイズと圧力との関係に関する基礎検討2019

    • Author(s)
      長岡 亮,大村眞朗,山口 匡,長谷川英之
    • Organizer
      日本音響学会2019年秋季研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] 超高速超音波断層法による心臓内血流ダイナミクスと流速ベクトルの可視化2019

    • Author(s)
      長岡 亮,茂澄倫也,長谷川英之
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 特異値分解を用いた頸動脈内腔領域抽出2019

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脈派の反射波成分の検出に関する基礎検討2019

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脈波伝搬速度検出のための超音波照射シークエンスに関する基礎検討 (Basic study on ultrasonic measurement sequence in estimation of pulse wave velocity)2019

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      日本音響学会2019年春季研究発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 特異値分解を用いたカラードプラ画像の正則化 (Regularization of color-Doppler images using singular value decomposition)2019

    • Author(s)
      茂澄倫也,長岡 亮,長谷川英之
    • Organizer
      日本音響学会2019年春季研究発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 2-D blood flow vector imaging in common carotid artery based on 2-step block matching method using envelope and RF signals2018

    • Author(s)
      Ryo Nagaoka, Michiya Mozumi, and Hideyuki Hasegawa
    • Organizer
      The 39th Symposium on Ultrasonic Electronics
    • Related Report
      2018 Research-status Report
  • [Presentation] Singular value decomposition of element echo signal received by individual elements for clutter reduction2018

    • Author(s)
      Michiya Mozumi, Ryo Nagaoka, and Hideyuki Hasegawa
    • Organizer
      The 39th Symposium on Ultrasonic Electronics
    • Related Report
      2018 Research-status Report
  • [Presentation] クトルドプラ法における血流速度推定に用いる超音波ビーム角度に関する基礎検討 (Basic study on ultrasound beam angle for estimation of blood flow velocity by vector Doppler method)2018

    • Author(s)
      長岡 亮,吉澤 晋,梅村晋一郎,長谷川英之
    • Organizer
      日本音響学会2018年秋季研究発表会講演論文集
    • Related Report
      2018 Research-status Report
  • [Presentation] シミュレーションファントムを用いたブロックマッチング法とベクトルドプラ法との血流速度推定精度比較に関する基礎検討 (Basic study on comparison of accuracies of vector Doppler and speckle tracking methods using simulation phantom)2018

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      日本音響学会2018年秋季研究発表会講演論文集
    • Related Report
      2018 Research-status Report
  • [Presentation] 回転ファントムを用いた2次元血流速度推定法に関する基礎検討 (Basic study on estimation method of two-dimensional blood flow using rotation phantom)2018

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      日本超音波医学会基礎技術研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高時間分解能超音波計測法におけるスペックルトラッキングの推定精度検証 (Verification Study on the Estimation Precision of Speckle Tracking Method in Ultrasonic Measurements with High Temporal Resolution)2018

    • Author(s)
      長岡 亮,長谷川英之
    • Organizer
      電子情報通信学会技術報告 (電子情報通信学会/音響学会 超音波研究会,日本音響学会 アコースティックイメージング研究会,日本超音波医学会 基礎技術研究会共催)
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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