Study of noninvasive aspiration detection using fluorescence food
| Project/Area Number |
18K18448
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Studies on the Super-Aging Society
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
YAMADA YUKIO 電気通信大学, 脳・医工学研究センター, 客員教授 (10334583)
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| Co-Investigator(Kenkyū-buntansha) |
小池 卓二 電気通信大学, 大学院情報理工学研究科, 教授 (10282097)
丹羽 治樹 電気通信大学, 脳・医工学研究センター, 特任教授 (20135297)
牧 昌次郎 電気通信大学, 大学院情報理工学研究科, 准教授 (20266349)
西村 吾朗 北海道大学, 電子科学研究所, 助教 (30218193)
道脇 幸博 昭和大学, 歯学部, 兼任講師 (40157540)
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 誤嚥 / 非侵襲検査法 / 近赤外光 / 蛍光 / 蛍光食品 / 高感度蛍光検出 / 梨状窩食物滞留 / 誤嚥検査 / 咽頭残留 / 誤嚥検査法 / 非侵襲 |
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| Outline of Final Research Achievements |
For the purpose of evaluating pulmonary aspiration, we have developed a technology to inspect food residue in the piriform sinus noninvasively and easily. When fluorescence food is remained in the piriform sinus, it can be detected by an optical probe attached to the skin for measuring fluorescence emitted from the food. Selection of fluorescence agent emitting near-infrared light with high penetration depth, development of an instrument having high sensitivity to near-infrared fluorescence as well as an optical probe, preliminary experiments using phantoms, and measurements for healthy elderly subjects were conducted.
It was confirmed that fluorescence from the depth of about 25 mm was detectable, and fluorescence from fluorescence food remained in the piriform sinus of healthy elderly subjects were detected. Consequently, we have established the fundamental technology for inspecting food residue in the piriform sinus noninvasively and easily.
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| Academic Significance and Societal Importance of the Research Achievements |
誤嚥性肺炎は，日本人高齢者の死因の上位にあり，誤嚥性肺炎を防ぐことは喫緊の課題である。誤嚥の危険性を検査する主な手法は嚥下造影（レントゲン）検査と嚥下内視鏡検査であるが，どちらも簡便ではなく，自宅や高齢者施設などで簡便に実施できる検査方法が望まれている。咽頭部の梨状窩への食物滞留を簡便に検出できれば，誤嚥のリスクを評価できる。本研究では，蛍光食品と高感度蛍光検出装置により，簡便に梨状窩への食物滞留を検知する技術の開発に成功した。この技術により自宅や高齢者施設において日常的に誤嚥のリスクが評価できれば，誤嚥性肺炎を防ぐことに大いに貢献すると考えられ，社会的意義が大きい。
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Spectroscopic properties of push-pull 2-(4-carboxyphenyl-6-dimethylaminobenzothiazole derivatives in solution and the solid state2019
Author(s)
Takahashi, Yusuke; Uehara, Takuya; Matsuhashi, Chihiro; Yamaji, Minoru; Mutai, Toshiki; Yoshikawa, Isao; Houjou, Hirohiko; Kitagawa, Kota; Suenobu, Tomoyoshi; Maki, Shojiro; Hirano, Takashi
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Journal Title
Journal of Photochemistry and Photobiology, A: Chemistry
Volume: 376
Pages: 324-332
DOI
Related Report
Peer Reviewed
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[Presentation] Substituent effects on compounds with specific growth inhibitory activity against T-cell acute2020
Author(s)
Y. Fujita, C. Yoshida, T. Higashi, Y. Hachiro, C. Nakata, T. Yagi, A. Takechi, N. Kitada, R. Obata, T. Hara, S. Maki
Organizer
The Irago Conference 2020, on line
Related Report
Int'l Joint Research
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[Presentation] Search for low molecular weight compounds showing proliferation inhibitory effect on acute T lymphoblastic leukemia (T-ALL) cells2019
Author(s)
Chihiro Yoshida, Yoshifumi Hachiro, Kazuya Miyashita, Takuya Yagi, Azusa Takechi, Ryohei Saito, Nobuo Kitada, Takashi Hirano, Takahiko Hara, Shojiro Maki
Organizer
Industry UCB, UEC, Keio Workshop 2019
Related Report
Int'l Joint Research
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