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Study of noninvasive aspiration detection using fluorescence food

Research Project

Project/Area Number 18K18448
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Studies on the Super-Aging Society
Research InstitutionThe University of Electro-Communications

Principal Investigator

YAMADA YUKIO  電気通信大学, 脳・医工学研究センター, 客員教授 (10334583)

Co-Investigator(Kenkyū-buntansha) 小池 卓二  電気通信大学, 大学院情報理工学研究科, 教授 (10282097)
丹羽 治樹  電気通信大学, 脳・医工学研究センター, 特任教授 (20135297)
牧 昌次郎  電気通信大学, 大学院情報理工学研究科, 准教授 (20266349)
西村 吾朗  北海道大学, 電子科学研究所, 助教 (30218193)
道脇 幸博  昭和大学, 歯学部, 兼任講師 (40157540)
Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords誤嚥 / 非侵襲検査法 / 近赤外光 / 蛍光 / 蛍光食品 / 高感度蛍光検出 / 梨状窩食物滞留 / 誤嚥検査 / 咽頭残留 / 誤嚥検査法 / 非侵襲
Outline of Final Research Achievements

For the purpose of evaluating pulmonary aspiration, we have developed a technology to inspect food residue in the piriform sinus noninvasively and easily. When fluorescence food is remained in the piriform sinus, it can be detected by an optical probe attached to the skin for measuring fluorescence emitted from the food. Selection of fluorescence agent emitting near-infrared light with high penetration depth, development of an instrument having high sensitivity to near-infrared fluorescence as well as an optical probe, preliminary experiments using phantoms, and measurements for healthy elderly subjects were conducted.
It was confirmed that fluorescence from the depth of about 25 mm was detectable, and fluorescence from fluorescence food remained in the piriform sinus of healthy elderly subjects were detected. Consequently, we have established the fundamental technology for inspecting food residue in the piriform sinus noninvasively and easily.

Academic Significance and Societal Importance of the Research Achievements

誤嚥性肺炎は,日本人高齢者の死因の上位にあり,誤嚥性肺炎を防ぐことは喫緊の課題である。誤嚥の危険性を検査する主な手法は嚥下造影(レントゲン)検査と嚥下内視鏡検査であるが,どちらも簡便ではなく,自宅や高齢者施設などで簡便に実施できる検査方法が望まれている。咽頭部の梨状窩への食物滞留を簡便に検出できれば,誤嚥のリスクを評価できる。本研究では,蛍光食品と高感度蛍光検出装置により,簡便に梨状窩への食物滞留を検知する技術の開発に成功した。この技術により自宅や高齢者施設において日常的に誤嚥のリスクが評価できれば,誤嚥性肺炎を防ぐことに大いに貢献すると考えられ,社会的意義が大きい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (61 results)

All 2021 2020 2019 2018

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 8 results) Presentation (39 results) (of which Int'l Joint Research: 14 results,  Invited: 7 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] On fluorescence imaging: The diffusion equation model and recovery of the absorption coefficient of fluorophores2021

    • Author(s)
      Liu Jijun、Machida Manabu、Nakamura Gen、Nishimura Goro、Sun Chunlong
    • Journal Title

      Science China Mathematics

      Volume: 64 Issue: 6 Pages: 1-20

    • DOI

      10.1007/s11425-020-1731-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells2021

    • Author(s)
      Yoshida Chihiro、Higashi Tomoya、Hachiro Yoshifumi、Fujita Yuki、Yagi Takuya、Takechi Azusa、Nakata Chihiro、Miyashita Kazuya、Kitada Nobuo、Saito Ryohei、Obata Rika、Hirano Takashi、Hara Takahiko、Maki Shojiro A.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 37 Pages: 127837-127837

    • DOI

      10.1016/j.bmcl.2021.127837

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How to Select Firefly Luciferin Analogues for In Vivo Imaging2021

    • Author(s)
      Saito-Moriya Ryohei、Nakayama Jun、Kamiya Genta、Kitada Nobuo、Obata Rika、Maki Shojiro A.、Aoyama Hiroshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 1848-1848

    • DOI

      10.3390/ijms22041848

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Color-tunable bioluminescence imaging portfolio for cell imaging2021

    • Author(s)
      Tamaki Shota、Kitada Nobuo、Kiyama Masahiro、Fujii Rika、Hirano Takashi、Kim Sung Bae、Maki Shojiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 2219-2219

    • DOI

      10.1038/s41598-021-81430-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comparative study of the delta-Eddington and Galerkin quadrature methods for highly forward scattering of photons in random media2020

    • Author(s)
      H. Fujii, G. Chiba, Y. Yamada, Y. Hoshi, K. Kobayashi, M. Watanabe
    • Journal Title

      Journal of Computational Physics

      Volume: 423 Pages: 109825-109825

    • DOI

      10.1016/j.jcp.2020.109825

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai2020

    • Author(s)
      Nakayama Jun、Saito Ryohei、Hayashi Yusuke、Kitada Nobuo、Tamaki Shota、Han Yuxuan、Semba Kentaro、Maki Shojiro A.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 21 Pages: 7896-7896

    • DOI

      10.3390/ijms21217896

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging2020

    • Author(s)
      Fukuchi Mamoru、Saito Ryohei、Maki Shojiro、Hagiwara Nami、Nakajima Yumena、Mitazaki Satoru、Izumi Hironori、Mori Hisashi
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 122-122

    • DOI

      10.1186/s13041-020-00665-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of near‐infrared firefly luciferin analogue reacted with wild‐type and mutant luciferases2020

    • Author(s)
      Kitada Nobuo、Saito Ryohei、Obata Rika、Iwano Satoshi、Karube Kazuma、Miyawaki Atsushi、Hirano Takashi、Maki Shojiro A.
    • Journal Title

      Chirality

      Volume: 32 Issue: 7 Pages: 922-931

    • DOI

      10.1002/chir.23236

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isomeric difference in the crystalline-state chemiluminescence property of an adamantylideneadamantane 1,2-dioxetane with a phthalimide chromophore2020

    • Author(s)
      Matsuhashi Chihiro、Ueno Takuya、Uekusa Hidehiro、Sato-Tomita Ayana、Ichiyanagi Kouhei、Maki Shojiro、Hirano Takashi
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 23 Pages: 3369-3372

    • DOI

      10.1039/c9cc10012a

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fast and robust reconstruction algorithm for fluorescence diffuse optical tomography assuming a cuboid target2020

    • Author(s)
      Sun Chunlong、Nakamura Gen、Nishimura Goro、Jiang Yu、Liu Jijun、Machida Manabu
    • Journal Title

      Journal of the Optical Society of America A

      Volume: 37 Issue: 2 Pages: 231-231

    • DOI

      10.1364/josaa.37.000231

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of Aging, Cognitive Dysfunction, Brain Atrophy on Hemoglobin Concentrations and Optical Pathlength at Rest in the Prefrontal Cortex: A Time-Resolved Spectroscopy Study2019

    • Author(s)
      Kaoru Sakatani, Lizhen Hu, Katsunori Oyama and Yukio Yamada
    • Journal Title

      Applied Sciences

      Volume: 9 Issue: 11 Pages: 2209-2209

    • DOI

      10.3390/app9112209

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Halogen-substituent effect on the spectroscopic properties of 2-phenyl-6-dimethylaminobenzothiazoles2019

    • Author(s)
      Misawa Rena、Matsuhashi Chihiro、Yamaji Minoru、Mutai Toshiki、Yoshikawa Isao、Houjou Hirohiko、Noguchi Keiichi、Maki Shojiro、Hirano Takashi
    • Journal Title

      Tetrahedron Letters

      Volume: 60 Issue: 26 Pages: 1702-1705

    • DOI

      10.1016/j.tetlet.2019.05.052

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spectroscopic properties of push-pull 2-(4-carboxyphenyl-6-dimethylaminobenzothiazole derivatives in solution and the solid state2019

    • Author(s)
      Takahashi, Yusuke; Uehara, Takuya; Matsuhashi, Chihiro; Yamaji, Minoru; Mutai, Toshiki; Yoshikawa, Isao; Houjou, Hirohiko; Kitagawa, Kota; Suenobu, Tomoyoshi; Maki, Shojiro; Hirano, Takashi
    • Journal Title

      Journal of Photochemistry and Photobiology, A: Chemistry

      Volume: 376 Pages: 324-332

    • DOI

      10.1016/j.jphotochem.2019.03.021

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Time-Domain Near-Infrared Spectroscopy and Imaging: A Review2019

    • Author(s)
      Yamada Yukio、Suzuki Hiroaki、Yamashita Yutaka
    • Journal Title

      Applied Sciences

      Volume: 9 Issue: 6 Pages: 1127-1127

    • DOI

      10.3390/app9061127

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contrast improvement in indocyanine green fluorescence sensing in thick tissue using a time-gating method2019

    • Author(s)
      Nishimura Goro
    • Journal Title

      Biomedical Optics Express

      Volume: 10 Issue: 3 Pages: 1234-1249

    • DOI

      10.1364/boe.10.001234

    • NAID

      120006711962

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and luminescence properties of near-infrared N-heterocyclic luciferin analogues for in vivo optical imaging2019

    • Author(s)
      Ryohei Saito, Takahiro Kuchimaru, Shoko Higashi, Shijia W. Lu, Masahiro Kiyama, Satoshi Iwano, Rika Obata, Takashi Hirano, Shinae Kizaka-Kondoh, Shojiro A. Maki
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 92 Issue: 3 Pages: 608-618

    • DOI

      10.1246/bcsj.20180350

    • NAID

      130007612635

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution2018

    • Author(s)
      Kitada Nobuo、Saitoh Tsuyoshi、Ikeda Yuma、Iwano Satoshi、Obata Rika、Niwa Haruki、Hirano Takashi、Miyawaki Atsushi、Suzuki Koji、Nishiyama Shigeru、Maki Shojiro A.
    • Journal Title

      Tetrahedron Letters

      Volume: 59 Issue: 12 Pages: 1087-1090

    • DOI

      10.1016/j.tetlet.2018.01.078

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 一重項酸素による近赤外発光を示す結晶化学発光系の構築2021

    • Author(s)
      山﨑 倫尚,松橋 千尋,植草 秀裕,牧 昌次郎,平野 誉
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 強発光蛍光団を連結したアダマンチリデンアダマンタン1,2-ジオキセタンの結晶化学発光特性評価2021

    • Author(s)
      松橋千尋,大山滉永,植草秀裕,佐藤文菜,一柳光平,牧昌次郎,平野誉
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] アミノルシフェリンアナログのホタル生物発光特性2021

    • Author(s)
      鈴木雄大,牧昌次郎,平野誉
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] マルチカラー発光を示す海洋生物由来発光システムの開発2021

    • Author(s)
      北田昇雄,玉城翔太,木山正啓,金誠培,平野誉,牧昌次郎
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ソフトクリスタルを志向した嵩高い置換基を有するアントラセン誘導体の合成と結晶構造、蛍光特性の評価2021

    • Author(s)
      納田菜摘,松橋千尋,石田尚行,齋藤大将,加藤昌子,牧昌次郎,平野誉
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 簡素化した天然物を用いた白血病細胞に対する新規抗腫瘍活性物質の開発2021

    • Author(s)
      東 智也,吉田 千紘,鉢呂 佳史,中田 千尋,八木 拓哉,武智 あづさ,北田 昇雄,原 孝彦,牧 昌次郎
    • Organizer
      日本化学会第101回春季年会 (オンライン3月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外蛍光を用いた非侵襲咽頭残留検出装置のヒトにおける検出性評価2020

    • Author(s)
      田代剛大,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,斎藤亮平,小池卓二,道脇幸博,西村吾朗
    • Organizer
      2020年度日本機械学会年次大会,オンライン開催
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外光による生体センシング--パルスオキシメータから拡散光トモグラフィまで--2020

    • Author(s)
      山田幸生
    • Organizer
      第24回 酸素ダイナミクス研究会,オンライン開催
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 近赤外蛍光を用いた咽頭残留の非侵襲検出法の開発:ファントムを用いた検出能評価2020

    • Author(s)
      田代剛大,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,斉藤亮平,小池卓二,道脇幸博,西村吾朗
    • Organizer
      日本光学会OPJ2020,オンライン開催
    • Related Report
      2020 Annual Research Report
  • [Presentation] Time‐domain fluorescence diffuse optical tomography using a cuboid2020

    • Author(s)
      C.-L. Sun, G. Nishimura, G. Nakamura, M. Machida, Y. Jiang, and J.-J. Liu
    • Organizer
      2020 OSA Biophotonics Congress: Biomedical Optics 2020, Virtual meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 直方体形状を仮定した拡散蛍光トモグラフィ2020

    • Author(s)
      Chunlong Sun, 西村吾朗,中村玄,町田学,Jijun Liu, Yu Jiang
    • Organizer
      日本光学会OPJ2020,オンライン開催
    • Related Report
      2020 Annual Research Report
  • [Presentation] Innovation of NIR luciferin analogues using firefly bioluminescence for in vivo imaging2020

    • Author(s)
      N. Kitada, R. Saito, S. Iwano, M. Kiyama, R. Obata, T. Hirano, S. Maki
    • Organizer
      The World Molecular Imaging Congress 2020, on line
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new luciferin analogues that emit near-infrared light through firefly bioluminescence2020

    • Author(s)
      G. Kamiya, N. Kitada, R. Saito, S. Iwano, R. Obata, T. Hirano, S. A. Maki
    • Organizer
      The World Molecular Imaging Congress 2020, on line
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of novel antitumor active drug for leukemia cells with simplified natural products2020

    • Author(s)
      T. Higashi, C. Yoshida, Y. Hachiro, C. Nakata, T. Yagi, A. Takechi, N. Kitada, T. Hara, S. Maki
    • Organizer
      The Irago Conference 2020, on line
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Substituent effects on compounds with specific growth inhibitory activity against T-cell acute2020

    • Author(s)
      Y. Fujita, C. Yoshida, T. Higashi, Y. Hachiro, C. Nakata, T. Yagi, A. Takechi, N. Kitada, R. Obata, T. Hara, S. Maki
    • Organizer
      The Irago Conference 2020, on line
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of new luciferin analogues that emit near-infrared light through firefly bioluminescence2020

    • Author(s)
      G. Kamiya, N. Kitada, R. Saito, S. Iwano, A. Miyawaki, T. Hirano, S. Maki
    • Organizer
      The Irago Conference 2020, on line
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 哺乳類由来酵素による肝臓発光現象2020

    • Author(s)
      林 唯奈,牧 昌次郎,齊藤 亮平,北田 昇雄,吉川 朋子,仲村 厚志
    • Organizer
      日本動物学会 第91回大会(オンライン9月)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 近赤外蛍光を用いた咽頭腔残留食物の非侵襲検出法の開発-ヒトを対象にした計測-2019

    • Author(s)
      田代剛大,鈴木嵩弘,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,齊藤亮平,小池卓二,西村吾朗,道脇幸博
    • Organizer
      日本機械学会 第30回バイオフロンティア講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] 誤嚥検査のための近赤外蛍光を用いた咽頭残留検出システムの開発2019

    • Author(s)
      田代剛大,鈴木嵩弘,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,齊藤亮平,小池卓二,道脇幸博,西村吾朗
    • Organizer
      日本光学会 OPJ2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Numerical treatment of highly forward-directed scattering on radiative transfer using the delta-m approximation and galerkin quadrature method2019

    • Author(s)
      Hiroyuki Fujii, Go Chiba, Yukio Yamada, Yoko Hoshi, Kazumichi Kobayashi, Masao Watanabe
    • Organizer
      The 9th International Symposium on Radiative Transfer (RAD-19)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ホタル生物発光を応用した,癌のin vivo イメージング2019

    • Author(s)
      牧 昌次郎
    • Organizer
      第3回先端光機能計測研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ホタル生物発光を応用した癌のin vivo光イメージング2019

    • Author(s)
      牧 昌次郎
    • Organizer
      化学最前線2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ホタル生物発光を応用した癌のin vivo光イメージング2019

    • Author(s)
      牧 昌次郎
    • Organizer
      Japan Analytical Instruments Active users Network
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Search for low molecular weight compounds showing proliferation inhibitory effect on acute T lymphoblastic leukemia (T-ALL) cells2019

    • Author(s)
      Chihiro Yoshida, Yoshifumi Hachiro, Kazuya Miyashita, Takuya Yagi, Azusa Takechi, Ryohei Saito, Nobuo Kitada, Takashi Hirano, Takahiko Hara, Shojiro Maki
    • Organizer
      Industry UCB, UEC, Keio Workshop 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] AkaBLI: An all-engineered bioluminescence system for highly sensitive in vivo imaging2019

    • Author(s)
      Satoshi Iwano, Shojiro Maki, Atsushi Miyawaki
    • Organizer
      Resonance Bio International Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] NIR Luciferin Analogues for in vivo Optical Imaging2019

    • Author(s)
      Nobuo Kitada, Ryohei Saito, Masahiro Kiyama, Satoshi Iwano, Rika Obata, Takashi Hirano, Shojiro Maki
    • Organizer
      2019 World Molecular Imaging Congress (WMIC)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensitivity of Fluorescence Signal in Strong Scattering Medium with Background Fluorescence2019

    • Author(s)
      Goro Nishimura
    • Organizer
      A3 Workshop in Applied Inverse Problems
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] in vivo 光イメージングに適した新規ルシフェリンアナログの開発2019

    • Author(s)
      齊藤 亮平、北田 昇雄、平野 誉、牧 昌次郎
    • Organizer
      日本化学会第99回春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 近赤外蛍光を用いた咽頭腔残留食物の非侵襲検出法の開発―誤嚥防止のための基礎研究―2018

    • Author(s)
      鈴木崇弘,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,斉藤亮平,小池卓二,西村吾朗,道脇幸博
    • Organizer
      第9回横幹連合コンファレンス
    • Related Report
      2018 Research-status Report
  • [Presentation] 誤嚥防止を目的とした近赤外蛍光による咽頭残留検出法の開発―検出可能深さ向上のための条件検討―2018

    • Author(s)
      鈴木崇弘,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,斉藤亮平,小池卓二,西村吾朗,道脇幸博
    • Organizer
      日本光学会年次学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 近赤外蛍光色素を用いた咽頭腔残留食物の非侵襲検出法の開発-ファントムを用いた予備実験-2018

    • Author(s)
      鈴木崇弘,山田幸生,丹羽治樹,牧昌次郎,北田昇雄,斉藤亮平,小池卓二,西村吾朗,道脇幸博
    • Organizer
      日本機械学会 第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Innovation of New Luciferin Analog for in vivo Optical Imaging2018

    • Author(s)
      N. Kitada, M. Kiyama, R. Saito, S. Lu, H. Niwa, T. Hirano, and S. Maki
    • Organizer
      20th International Symposium on Bioluminescence and Chemiluminescence
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fluorescence Image Contrast Improvement by a Time-domain Method2018

    • Author(s)
      Goro Nishimura
    • Organizer
      2018 OSA Biophotonics Congress: Biomedical Optics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 組織深部拡散蛍光トモグラフィー:時間領域からのアプローチ2018

    • Author(s)
      西村吾朗
    • Organizer
      第37回日本医用画像工学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Time-Domain Optical Tomography For Fluorescence Objects2018

    • Author(s)
      Goro Nishimura
    • Organizer
      Tianyuan Workshop on Mathematical and Computational Challenges of Medical Imaging and Inverse Problems
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体組織中にある蛍光ターゲットの高感度検出 (2)2018

    • Author(s)
      西村吾朗
    • Organizer
      Optics and Photonics Japan 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 医療応用のための近赤外蛍光プローブの高感度検出2018

    • Author(s)
      西村吾朗
    • Organizer
      近赤外フォーラム 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] in vivo 光イメージングに適した高水溶性近赤外ホタルルシフェリンアナログの合成と実用化2018

    • Author(s)
      齊藤 亮平,北田 昇雄,木山 正啓,東 翔子,魯 仕嘉ウィンソン,小畠 りか,平野 誉,牧 昌次郎
    • Organizer
      第22回 酸素ダイナミクス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] ホタルルシフェリン誘導体によるマウス肝臓の発光2018

    • Author(s)
      仲村 厚志,林 唯奈,齊藤 亮平,牧 昌次郎,吉川 朋子
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Book] 「実験医学別冊発光イメージング実験ガイド」発展編 第1章「生体内深部可視化を可能とするホタル生物発光型長波長発光材料」2019

    • Author(s)
      牧 昌次郎
    • Total Pages
      4
    • Publisher
      羊土社
    • Related Report
      2019 Research-status Report
  • [Book] 「実験医学別冊発光イメージング実験ガイド」発展編 第2章「動物にやさしいin vivo生物発光イメージング」2019

    • Author(s)
      岩野 智,牧 昌次郎,宮脇 敦史
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2019 Research-status Report
  • [Book] 「次世代のポリマー・高分子開発,新しい用途展開と将来展望」第10章第5節「生物機能模倣による,発光イメージング技術が 拓く次世代医療技術」2019

    • Author(s)
      牧 昌次郎
    • Total Pages
      6
    • Publisher
      技術情報協会
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 検出装置、検出方法、及び検出器2020

    • Inventor(s)
      山田幸生, 西村吾朗, 丹羽治樹, 牧昌次郎, 道脇幸博ほか3名
    • Industrial Property Rights Holder
      山田幸生, 西村吾朗, 丹羽治樹, 牧昌次郎, 道脇幸博ほか3名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-123183
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 検出装置、検出方法、及び検出器2019

    • Inventor(s)
      山田幸生,西村吾朗,丹羽治樹,牧昌次郎,道脇幸博,小池卓二,他
    • Industrial Property Rights Holder
      山田幸生,西村吾朗,丹羽治樹,牧昌次郎,道脇幸博,小池卓二,他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-132298
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2018-07-25   Modified: 2022-01-27  

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