| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Prolonged two-point discrimination and the number of correct answers on the double-flush test were associated with cognitive function test scores independent of age, gender, and short educational history, which are established risk factors for dementia. This association was also independent of hippocampal volume. Among the various clinical information collected in the Nagahama cohort, accumulation of AGEs measured by skin fluorescence method showed a significant negative association with cognitive function test scores. However, the association between two-point discrimination and double-flash test and cognitive function were independent of AGEs accumulation. Results of the ROC curve analysis indicated that the double-flush test had a discrimination ability for suspected dementia.
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