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Food science based novel approach, food chemical epigenetics, toward prevention and treatment of osteoporosis

Research Project

Project/Area Number 18K18455
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Studies on the Super-Aging Society
Research InstitutionOsaka University

Principal Investigator

Nishikawa Keizo  大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (30516290)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords破骨細胞 / 骨芽細胞 / エピジェネティクス / フードケミカルエピジェネティクス / 骨粗鬆症 / 機能性食品 / 運動器障害 / 食品化合物 / 機能性化合物 / 食品
Outline of Final Research Achievements

In this study, we identified a novel epigenetic regulator Ochd involved in the regulation of osteoclast differentiation. A significant increase in bone mass and a decrease in the number of osteoclasts were observed in mice lacking osteoclast-specific Ochd. From these results, Ochd is expected to be a drug target for osteoporosis. Therefore, we searched for candidate compounds capable of binding to Ochd by in silico analysis. Then, using the obtained 14 candidate compounds, the effect on osteoclast differentiation was examined. As a result, we succeeded in identifying 3 kinds of compounds having an effect of significantly inhibiting osteoclast differentiation and 1 kind of compound having an promoting effect.

Academic Significance and Societal Importance of the Research Achievements

未曾有の超高齢化が進行しつつある我が国において、高齢者の健康寿命の延伸は喫緊の課題に挙げられる。本研究成果では、高齢者の身体的フレイルの要因となる骨粗鬆症に注目し、研究代表者が取り組むエピゲノム創薬と食品科学研究を融合したフードケミカルエピジェネティクスを活用することで、骨粗鬆症を予防するための候補化合物の同定に成功を収めたことから、今後当該化合物によって、骨粗鬆症を未病の段階で食い止める新たな予防法の開発につながることが期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (2 results)

  • [Journal Article] Roles of enhancer RNAs in RANKL-induced osteoclast differentiation identified by genome wide cap analysis of gene expression using CRISPR/Cas9.2018

    • Author(s)
      3.Sakaguchi Y, Nishikawa K, Seno S, Matsuda H, Takayanagi H and Ishii M
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 7504-7504

    • DOI

      10.1038/s41598-018-25748-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018

    • Author(s)
      3.Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, and Suda T.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 33 Issue: 10 Pages: 1785-1798

    • DOI

      10.1002/jbmr.3477

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 骨吸収マクロファージ「破骨細胞」における環境応答を介した細胞分化制御機構の研究2019

    • Author(s)
      西川恵三
    • Organizer
      第16回レドックス・ライフイノベーションシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 二光子りん光・蛍光寿命イメージング法を用いた酸素に対する代謝応答のin vivo解析2019

    • Author(s)
      西川恵三、楢崎綾子、吉原利忠、坂口怜子、飛田成史、森泰生、石井優
    • Organizer
      第44回レーザー顕微鏡研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] in vivo酸素環境の定量的理解2019

    • Author(s)
      西川恵三、楢崎綾子、吉原利忠、坂口怜子、飛田成史、森泰生、石井優
    • Organizer
      第5回日本骨免疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 二光子励起寿命イメージングによる生体内酸素分圧の定量的解析2019

    • Author(s)
      西川恵三、楢崎綾子、吉原利忠、坂口怜子、飛田成史、森泰生、石井優
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Quantification of oxygen tension in bone marrow using intravital two-photon phosphorescence lifetime imaging2019

    • Author(s)
      楢崎綾子、西川恵三、吉原利忠、坂口怜子、飛田成史、森泰生、石井優
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 破骨細胞の酸素生物学2018

    • Author(s)
      西川恵三
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 骨粗鬆症の改善を目指したフードケミカルエピジェネティクスの研究2018

    • Author(s)
      西川恵三
    • Organizer
      第22回日本フードファクター学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Immunometabolism: role of metabolic reprogramming in osteoclastogeneisis2018

    • Author(s)
      Nishikawa K
    • Organizer
      15th Bone Biology Forum
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 骨吸収マクロファージ「破骨細胞」における代謝制御の重要性2018

    • Author(s)
      西川恵三
    • Organizer
      第37回日本炎症・再生医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 二光子リン光寿命イメージングを活用した骨髄内細胞における酸素分圧の定量解析2018

    • Author(s)
      楢崎綾子、西川恵三、吉原利忠、坂口怜子、飛田成史、森泰生、石井優
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Book] 骨研究の最前線 Frontiers in Bone Research(石井優 編集)2019

    • Author(s)
      石井優、西川恵三
    • Total Pages
      116
    • Publisher
      北隆館
    • Related Report
      2019 Annual Research Report
  • [Book] 茶ポリフェノールの生理機能と応用展開(立花宏文 編集)2019

    • Author(s)
      西川恵三
    • Total Pages
      238
    • Publisher
      シーエムシー出版
    • ISBN
      4781314333
    • Related Report
      2019 Annual Research Report

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Published: 2018-07-25   Modified: 2021-02-19  

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