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Development of Smart Electronics Sheet Within Cardiac Cell Sheet

Research Project

Project/Area Number 18K18838
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 20:Mechanical dynamics, robotics, and related fields
Research InstitutionWaseda University

Principal Investigator

Umezu Shinjiro  早稲田大学, 理工学術院, 教授 (70373032)

Co-Investigator(Kenkyū-buntansha) 坂口 勝久  早稲田大学, 理工学術院, 准教授(任期付) (70468867)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords心筋細胞 / スマートエレクトロニクスシート / 孔 / スキャフォールド / 心筋細胞組織 / エレクトロニクスシート / 生体情報 / バイオエレクトロニクス / サイボーグ / バイオファブリケーション
Outline of Final Research Achievements

Recent days, studies on vital data sensing utilizing flexible electronics are carried out by many researchers for the purpose of curing undiagnosed diseases and health monitoring. Additionally, studies on bio-actuator utilizing cardiac muscle cells are highly focused. For both studies, thin film electronics scaffolds which have many holes are essential.
In this study, fabrication process of thin film which has many holes is confirmed. After this, mechanical characteristics and bio characteristics are investigated.

Academic Significance and Societal Importance of the Research Achievements

薄膜エレクトロニクスは十分に薄いため、心筋細胞の動きを妨げにくいというメリットが既にあります。しかし、薄膜エレクトロニクスに孔を設けることによって、スキャフォールドとしての剛性をさらに低下できますので、心筋細胞の動きをさらに妨げにくくなります。そして、孔があることによって、心筋細胞同士の物理的な接触がさらに増えることによるバイオ特性の向上におけるメリットも得られました。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (11 results) (of which Int'l Joint Research: 8 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Paper based electrochemical sensors using paper as scaffold to create porous carbon nanotube electrodes2020

    • Author(s)
      Christopher J. Valentine, Kensuke Takagishi, Shinjiro Umezu, Ronan Daly, and Michael De Volder
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: XXX Issue: 27 Pages: 30680-30685

    • DOI

      10.1021/acsami.0c04896

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simple action potential measurement of cardiac cell sheet utilizing electronic sheet2018

    • Author(s)
      Ohya Takashi、Nakazono Kazuki、Kikuchi Tetsutaro、Sasaki Daisuke、Sakaguchi Katsuhisa、Shimizu Tatsuya、Fukuda Kenjiro、Someya Takao、Umezu Shinjiro
    • Journal Title

      Artificial Life and Robotics

      Volume: in printing Issue: 3 Pages: 321-327

    • DOI

      10.1007/s10015-018-0429-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Investigation on the physical and electrical stability and cytotoxicity of ultra-thin bio sensor with chromium layer in culture medium2020

    • Author(s)
      Takashi Ohya, Hayato Ogawa, Tetsutaro Kikuchi, Daisuke Sasaki, Tatsuya Shimizu, Katsuhisa Matsuura, Kenjiro Fukuda, Takao Someya, Shinjiro Umezu
    • Organizer
      5th International Symposium on Bicocomplexity
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Study of fabrication process of ultra-flexible thin-film with micro structure and change of mechanical property by structure2019

    • Author(s)
      Takashi Ohya, Tetsutaro Kikuchi, Daisuke. Sasaki, Yohei Kawamura, Katsuhisa. Matsuura, Tatsuya. Shimizu, Kenjiro. Fukuda, Takao Someya and Shinjiro Umezu
    • Organizer
      International conference of flexible and printed electronics 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 柔軟性を有するシリコーン薄膜のバイオセンサへの応用研究2019

    • Author(s)
      大矢貴史,菊地鉄太郎, 佐々木大輔, 松浦勝久, 清水達也, 福田憲二郎, 染谷隆夫, 梅津信二郎
    • Organizer
      画像関連学会連合会第六回秋季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] フレキシブルエレクトロニクス、バイオファブリケーション技術の融合による 高精度薬効評価システム・バイオポンプの開発2019

    • Author(s)
      大矢貴史,菊地鉄太郎, 佐々木大輔, 松浦勝久, 清水達也, 福田憲二郎, 染谷隆夫, 梅津信二郎
    • Organizer
      第二回ソフトロボット創世シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 加工速度がゼラチンゲルへのマイクロ放電加工に及ぼす影響2019

    • Author(s)
      秋山亮太朗,田村隆行,梅津信二郎
    • Organizer
      日本機械学会2019年茨城講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fundamental study for measuring contractile force of cardiomyocytes by using ultraflexible film2019

    • Author(s)
      Haruki Ohtomo, Takashi Ohya, Tetsutaro Kikuchi, Daisuke Sasaki, Tatsuya Shimizu, Katsuhisa Matsuura ,Kenjiro Fukuda, Takao Someya, Shinjiro Umezu
    • Organizer
      24th International Symposium on Artificial Life and Robotics AROB 24th 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Electrode Material for Vital Monitoring that is Non-invasive to Everyday Life2019

    • Author(s)
      Tsubasa Sui,Toshinori Fujie,Kayo Hirose, Shinjiro Umezu
    • Organizer
      24th International Symposium on Artificial Life and Robotics AROB 24th 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Body temperature measurement of baby utilizing MEMS sensor sheet2019

    • Author(s)
      Hayato Ogawa, Shinjiro Umezu
    • Organizer
      24th International Symposium on Artificial Life and Robotics AROB 24th 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fundamental Study of the Microfabrication Method of Thin-film Material for BioMEMS2019

    • Author(s)
      Takashi Ohya, Tetsutaro Kikuchi, Daisuke Sasaki, Tatsuya Shimizu, Katsuhisa Matsuura ,Kenjiro Fukuda, Takao Someya, Shinjiro Umezu
    • Organizer
      24th International Symposium on Artificial Life and Robotics AROB 24th 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multipoint Extracellular Electric Potential Measurement of Human iPS Cardiomyocyte by Using Flexible Electronic Sheet2018

    • Author(s)
      akashi Ohya, Tetsutaro Kikuchi, Daisuke Sasaki, Tatsuya Shimizu, Katsuhisa Matsuura ,Kenjiro Fukuda, Takao Someya, Shinjiro Umezu
    • Organizer
      9th International Conference on Flexible and Printed Electronics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Grooves on Gelatin Film Utilizing Micro-Electrical Discharge Machining (micro-EDM)2018

    • Author(s)
      Takayuki Tamura, Ryotaro Akiyama, Ryu-ichiro Tanaka, Shinjiro Umezu
    • Organizer
      9th International Conference on Flexible and Printed Electronics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 心電モニタリングシステム2018

    • Inventor(s)
      梅津信二郎、廣瀬佳代、藤枝俊宣
    • Industrial Property Rights Holder
      梅津信二郎、廣瀬佳代、藤枝俊宣
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 人工血管ユニットの製造方法及び人工血管ユニット2018

    • Inventor(s)
      梅津信二郎、坂口勝久、秋元渓、清水達也
    • Industrial Property Rights Holder
      梅津信二郎、坂口勝久、秋元渓、清水達也
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] センサフィルム及び積層体2018

    • Inventor(s)
      大矢、梅津、福田、染谷、菊地、佐々木、清水
    • Industrial Property Rights Holder
      大矢、梅津、福田、染谷、菊地、佐々木、清水
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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