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Development of time-reversal measurement technique using phase-conjugate wave for noninvasive spectral analysis of animal body

Research Project

Project/Area Number 18K18865
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 21:Electrical and electronic engineering and related fields
Research InstitutionWaseda University

Principal Investigator

Koichi Shimizu  早稲田大学, 理工学術院(情報生産システム研究科・センター), 教授(任期付) (30125322)

Co-Investigator(Kenkyū-buntansha) 加藤 祐次  北海道大学, 情報科学研究院, 助教 (50261582)
北間 正崇  北海道科学大学, 保健医療学部, 教授 (50285516)
浪田 健  京都大学, 医学研究科, 特定助教 (10571250)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords位相共役波 / 位相共役光 / 時間反転 / 光散乱 / 光伝搬 / ホログラム / 空間光変調器 / 輸送方程式 / 位相共役 / 生体計測 / 無侵襲計測 / 分光計測 / 拡散
Outline of Final Research Achievements

For noninvasive spectral analysis in a human body, we attempted the development of a localized absorption measurement technique in a turbid medium by introducing a new time-reversal principle using a phase-conjugate light. The following accomplishments were achieved, and clear imaging of internal structure in a turbid medium became possible.
(1) A new technique to generate phase-conjugate light with intensity modulation was devised. (2) An experimental system for the time-reversal phenomenon was developed and improved. (3) The scattering suppression ability of the proposed technique was evaluated. (4) The independence of the scattering suppression on the light absorption in the medium was confirmed. (5) The system performance was improved by increasing the coherent length of light source. (6) The applicability of the proposed technique to animal tissue was verified.

Academic Significance and Societal Importance of the Research Achievements

本研究により、これまで不可能と考えられてきた強散乱体内部の局所領域分光が可能なことが、具体的に示された。これにより、従来の分光学の常識に新たな一頁を開くことができる。例えば、透過光の得られない拡散性散乱体の内部であっても、表面からの光が届く限り、内部局所領域を特定した分光が可能となる。またその成果は、本研究で直接応用をめざす生体の無侵襲生理情報計測に利用される。例えば、介在組織の影響でこれまで実用精度が得られなかった無侵襲血糖値計測や、体表からの肝(腎・膵)機能検査、脳内梗塞(出血)部位の実時間連続分光などが実現される。さらに提案手法の基本原理は、生体以外の分野へも多くの応用が考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (37 results)

All 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results)

  • [Int'l Joint Research] Xidian University(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ho Chi Minh City Univ. of Tech.(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Ho Chi Minh City Univ. of Technology(ベトナム)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Nonlinear inversion technique for absorption tomography of turbid media using spatially resolved backscattered light2020

    • Author(s)
      Nishida Kazuhiro、Kato Yuji、Kudo Nobuki、Shimizu Koichi
    • Journal Title

      Optics and Lasers in Engineering

      Volume: 126 Pages: 1-11

    • DOI

      10.1016/j.optlaseng.2019.105891

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of three-dimensional physiological function imaging of biological body by transillumination imaging using near infrared light - preliminary research -2020

    • Author(s)
      Dang Nguyen Ngoc An、Bui Phuong Anh、Tran Anh Tu、Dang Nguyen Trung An、Nguyen Van Chinh、Shimizu Koichi、Tran Trung Nghia
    • Journal Title

      Proceedings of ISAS

      Volume: 3 Pages: 11-18

    • DOI

      10.29007/dvzs

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of absorption coefficient and coherence length on time-reverse scattering suppression using digital phase-conjugate light2019

    • Author(s)
      Toda Sogo、Kato Yuji、Kudo Nobuki、Shimizu Koichi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: 3 Pages: 1-4

    • DOI

      10.7567/1347-4065/aafc1f

    • NAID

      210000135355

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of scattering suppression effect of time-reversal propagation using digital phaseconjugate light2019

    • Author(s)
      Toda Sogo、Kato Yuji、Kudo Nobuki、Shimizu Koichi
    • Journal Title

      SPIE Proceedings

      Volume: 10886 Pages: 1-6

    • DOI

      10.1117/12.2505213

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of digital phase-conjugate light intensity on time-reversal imaging through animal2018

    • Author(s)
      Toda Sogo、Kato Yuji、Kudo Nobuki、Shimizu Koichi
    • Journal Title

      Biomedical Optics Express

      Volume: 9 Issue: 4 Pages: 1570-1581

    • DOI

      10.1364/boe.9.001570

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Functional transillumination imaging of animal body with NIR light scattering2020

    • Author(s)
      Koichi Shimizu
    • Organizer
      European Lasers, Photonics and Optics Technologies Summit
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Depth Estimation of Blood Vessels in 2D NIR Transillumination Images using Machine Learning2020

    • Author(s)
      Yingdong Chen and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Deblurring of NIR transillumination images by deep learning2020

    • Author(s)
      Youjie Wang and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Attempt for transillumination imaging along irregular-shape surface2020

    • Author(s)
      Xiao Wang, Phan Van To Ni and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of real-time system for NIR functional transillumination imaging2020

    • Author(s)
      Yu Du and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Monte-Carlo simulation of light propagation in human tissue for noninvasive measurement of blood turbidity2020

    • Author(s)
      Yingshuai Fan, Shiyang Liang and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Experimental verification of scattering estimation from backscattered light for noninvasive evaluation of blood turbidity2020

    • Author(s)
      Yang Cui, Shiyang Liang and Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Non-invasive optical measurement of blood turbidity in capillary2020

    • Author(s)
      Gang Wang, Motoshi Sobue, Koichi Shimizu
    • Organizer
      第59回日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] From War to Peace in Optical Engineering - Befriending light scattering for biomedical applications2019

    • Author(s)
      Koichi Shimizu (keynote)
    • Organizer
      ISIPS 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Three dimensional transillumination imaging of human body using near-infrared light2019

    • Author(s)
      To Ni Phan Van, Trung Nghia Tran, and Koichi Shimizu
    • Organizer
      ISIPS 2019 (Best presentation award)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of new optical technique for noninvasive measurement of blood turbidity2019

    • Author(s)
      Shiyang Liang and Koichi Shimizu
    • Organizer
      ISIPS 2019 (Best presentation award)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Extraction of blood vessel image by deep learning in NIR transillumination imaging2019

    • Author(s)
      Jiazhe Wang and Koichi Shimizu
    • Organizer
      日本光学会年次学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Noise reduction of hyper-spectral image for NIR functional transillumination imaging of human body2019

    • Author(s)
      Yu Ye and Koichi Shimizu
    • Organizer
      日本光学会年次学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Improvement of scattering suppression effect of time-reversal propagation using digital phase-conjugate light2019

    • Author(s)
      S. Toda, Y. Kato, N. Kudo, K. Shimizu
    • Organizer
      BiOS 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Three dimensional transillumination imaging of human body using near-infrared light - Preliminary study using deep learning -2019

    • Author(s)
      To Ni Phan Van, Trung Nghia Tran, Tuan Vo Ngoc Anh, Koichi Shimizu
    • Organizer
      13th SEATUC Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional transillumination imaging of human body using near-infrared light2018

    • Author(s)
      Koichi Shimizu
    • Organizer
      Annual Meeting of APSCIT
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of digital phase-conjugate light intensity on time-reversal imaging of scattering medium2018

    • Author(s)
      Sogo Toda, Yuji Kato, Nobuki Kudo, Koichi Shimizu
    • Organizer
      Annual Meeting of APSCIT
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fundamental study for transillumination imaging of arteriovenous fistula2018

    • Author(s)
      M. Kitama, H. Kamiyama, M. Yamashita, H. O. Shimizu, G. Okuyama, A. Kikuchi, K. Shimizu
    • Organizer
      Annual Meeting of APSCIT
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Macroscopic 3D transillumination imaging of animal body by scattering suppression of NIR light2018

    • Author(s)
      Koichi Shimizu
    • Organizer
      International Conference on Lasers, Optics and Photonics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Three dimensional transillumination imaging of human body using near-infrared light - Proposal of new application of deep learning -2018

    • Author(s)
      Phan Van To Ni, Tran Trung Nghia, Tuan Vo Ngoc Anh, Koichi Shimizu
    • Organizer
      12th ISIPS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ディジタル位相共役光による生体組織を介した光源像回復の試み2018

    • Author(s)
      任田崇吾,加藤祐次,工藤信樹,清水孝一
    • Organizer
      レーザー学会研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 臨床応用に向けた内シャント光イメージングの基礎的検討-困難な血管狭窄透視実現の試み-2018

    • Author(s)
      神山英昇, 北間正崇, 清水久恵, 山下政司, 菊池明泰, 奥山豪, 小島洋一郎, 清水孝一
    • Organizer
      第57回日本生体医工学会北海道支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Estimation of absorber depth in transillumination image by deep learning2018

    • Author(s)
      Xuan Wang and Koichi Shimizu
    • Organizer
      Optics & Photonics Japan 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体の光透視像におけるピクセル毎の連続波長分光解析の試み2018

    • Author(s)
      中川紘平,清水孝一
    • Organizer
      Optics & Photonics Japan 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] 深層学習による生体の光透視像改善手法の開発2018

    • Author(s)
      赤坂謙,清水孝一
    • Organizer
      Optics & Photonics Japan 2018
    • Related Report
      2018 Research-status Report
  • [Presentation] Simulation analysis on light propagation in inhomogeneous scattering medium for noninvasive optical measurement of blood turbidity2018

    • Author(s)
      Weichang Feng and Koichi Shimizu
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of optical transillumination system for functional imaging of human foot2018

    • Author(s)
      Zejing Han and Koichi Shimizu
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of optical system for noninvasive measurement of blood turbidity2018

    • Author(s)
      Liang Shiyang and Koichi Shimizu
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Depth estimation of absorbing object in turbid medium from optical transillumination image2018

    • Author(s)
      Xu Luhang and Koichi Shimizu
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2021-02-19  

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