| Project/Area Number |
18K18950
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 26:Materials engineering and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
Matsugaki Aira 大阪大学, 工学研究科, 特任講師(常勤) (10592529)
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| Co-Investigator(Kenkyū-buntansha) |
中野 貴由 大阪大学, 工学研究科, 教授 (30243182)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 骨芽細胞 / 細胞配列 / 塑性変形 / すべり変形 / 双晶変形 / すべり線 / 双晶トレース / 金属結晶 |
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| Outline of Final Research Achievements |
Control of osteoblast arrangement is essential for anisotropic bone tissue construction. In this study, a crystallography-driven methodology was proposed as a novel tool for controlling cellular arrangement. A specific surface topography derived from dislocation and deformation twinning was introduced into α-titanium crystals. Primary osteoblasts were aligned along the twinning traces and/or slip traces, and accumulation of the mature focal adhesions was observed in the same direction. These results indicated that the highly concentrated twinning traces with nanometer-scale relief structures induced the elongation and maturation of focal adhesions and the resulting cellular elongation and alignment. These findings provide important insights into the mechanisms underlying the interactions between cells and materials and the development of biomedical devices that can control bone tissue anisotropy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、一見大きく異なる学問分野である結晶塑性学と細胞生物学の融合により、既存の学術体系を見直し、材料表面―生体細胞相互作用に基づく骨配向化制御の新たな原理を発見した。世界に先駆けて骨配向性制御の新たな方法論を確立し、部位や種類に応じて様々な配向方向・配向度を示す骨の配向性を自由自在にコントロール可能な材料創製につながる、極めて独創性が高く、基礎・実用研究両面において意義深い成果を得た。
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