Is it possible to lower the rotational barrier of axially chiral biarlys?
| Project/Area Number |
18K19084
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 33:Organic chemistry and related fields
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| Research Institution | Gakushuin University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 不斉合成 / 軸性不斉化合物 / ビアリール / 回転障壁 / 不斉触媒 / 不斉触媒反応 / 軸性不斉 / キラリティー / 動的速度論的光学分割 / 速度論的光学分割 / 還元的アミノ化反応 / 有機分子触媒 / 軸不斉 / キラルリン酸 |
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| Outline of Final Research Achievements |
Biaryls bearing multiple substituents at the o-positions may generate atropisomers because the rotational barriers of the single of the biaryl become higher. The axially chiral compounds are frequently found in chiral ligands, chiral catalysts, and biologically active compounds. We tried to lower the rotational barrier of the axially chiral compounds.
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| Academic Significance and Societal Importance of the Research Achievements |
ビアリール化合物は，不斉配位子，キラル触媒等，不斉触媒反応において数多く用いられている。これらの軸性不斉化合物の回転障壁を下げることができれば，新たな不斉触媒反応の開発につながる可能性があり，学術的に意義があると考えられる。また，それにより，新たな合成法が開拓できれば，医薬品産業への貢献も期待できる。
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Report
(3 results)
Research Products
(2 results)
