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Investigation of biomolecular activity in liposomes mimicking the surface of cell membranes

Research Project

Project/Area Number 18K19157
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 37:Biomolecular chemistry and related fields
Research InstitutionGunma University

Principal Investigator

Kamiya Koki  群馬大学, 大学院理工学府, 助教 (70612315)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsリポソーム / リン脂質二重膜 / リン脂質非対称膜 / 膜タンパク質 / マイクロドメイン / マイクロデバイス / 人工細胞膜 / 膜融合 / ベシクル / 人工細胞モデル
Outline of Final Research Achievements

Giant lipid vesicles with asymmetric lipid bilayer which mimics a plasma membrane of eukaryotic cells were generated by applying a jet flow against a planar asymmetric lipid bilayer (pulsed jet flow method). The plasma membranes are also composed of microdomains and glycolipids. In this study, to improve emulations of the plasma membrane of eukaryotic cells, cell-sized asymmetric lipid vesicles with microdomains and glycolipids were generated by the pulsed jet flow method.

Academic Significance and Societal Importance of the Research Achievements

膜ドメインや糖鎖を導入した細胞膜を模倣したリン脂質非対称膜上で、ペプチドや膜タンパク質等の生体分子の相互作用を観察することで、これらの生体分子の素反応を理解できる。よって、精密な生体分子の素反応の理解は、細胞システムのメカニズムの解明や薬剤の活性部位の特定に役立つ。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 Other

All Journal Article (1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Remarks (2 results)

  • [Journal Article] リン脂質非対称膜リポソームの形成と機能観察2019

    • Author(s)
      神谷厚輝
    • Journal Title

      化学と工業

      Volume: 72 Pages: 1049-1050

    • Related Report
      2019 Annual Research Report
  • [Presentation] Asymmetric lipid vesicle generation for creating complex artificial cells2019

    • Author(s)
      Koki Kamiya
    • Organizer
      MARSS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロデバイスによる細胞膜模倣型人工細胞膜の創成と機能観察2019

    • Author(s)
      神谷厚輝
    • Organizer
      化学とマイクロ・ナノシステム学会 第39回研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 複雑な生命現象の理解に向けた細胞膜模倣型人工細胞膜の創成2019

    • Author(s)
      神谷厚輝
    • Organizer
      群馬大学第26回生命科学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ナノサイズリポソームの平面膜への融合条件の検討2019

    • Author(s)
      蟻坂知佳、神谷厚輝
    • Organizer
      日本化学会関東支部群馬地区研究交流会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 平面膜に対する小胞融合の最適条件の模索2019

    • Author(s)
      蟻坂知佳、神谷厚輝
    • Organizer
      第6回サイボウニクス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞膜環境を模倣した人工細胞膜の創出2019

    • Author(s)
      神谷厚輝
    • Organizer
      日本化学会 第99春季年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] FORMATION OF CELL-SIZED ASYMMETRIC LIPID VESICLES WITH LIPID MICRODOMAINS2018

    • Author(s)
      Koki Kamiya, Toshihisa Osaki, Shoji Takeuchi
    • Organizer
      MicroTAS2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 群馬大学 大学院理工学府 分子科学部門 神谷研究室

    • URL

      http://kamiya.chem-bio.st.gunma-u.ac.jp/index2.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 群馬大学 大学院理工学府 分子科学部門 神谷研究室

    • URL

      http://kamiya.chem-bio.st.gunma-u.ac.jp/index2.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-07-25   Modified: 2021-02-19  

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