| Budget Amount *help |
¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In order to make cell growth compatible with microbial production of value-added compounds on methanol, this study aimed to establish the pathway substitutes for methanol assimilation pathway in the methylotrophic bacterium. Although methanol was assimilated by introduced substitute pathway, restoration of methylotrophic growth was not observed in the cells disrupted central metabolic pathway. On the other hand, reduced growth of the cells in which enzyme catalyzing reaction opposite to central metabolic pathway was introduced, was restored by introducing substitute pathway. This observation might be useful to achieve high production yield of value-added compounds from methanol.
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