| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Hypothalamic preoptic area (POA) is well known as a hyperthermic center. PGE2, a strong pyrogen, induces fever by binding to their receptor in POA. We have recently found that mice lacking Prostaglandin E2 synthesis enzyme (mPGES-1) do not show fever but hypothermic response to immune challenge only when they are at pro-estrus or estrus stage. The findings of our present project established the following hypotheses. 1) There is a hypothermic center which is activated by immune challenges simultaneously with the hyperthermic center. 2) The Parabrachial Nnucleus (PBN) in the brainstem receives the infectious information in the peripheral tissues and transports it selectively to the hyper- or hypothermic center in the hypothalamus. 3) Estrogen from the ovary enhances the sensitivity of this hypothermia-driving mechanism.
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