Elucidation of the mechanism of a new fossil fuel-independent thermal stress reduction process
| Project/Area Number |
18K19271
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 42:Veterinary medical science, animal science, and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田代 康介 九州大学, 農学研究院, 准教授 (00192170)
豊後 貴嗣 広島大学, 統合生命科学研究科(生), 教授 (40325361)
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | ニワトリ / 耐暑性 / ロイシン / シトルリン / ストレス軽減 / L-ロイシン / L-シトルリン / ブロイラー / インプリンティング |
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| Outline of Final Research Achievements |
In this project, we have found that L-leucine (L-Leu) and L-citrulline (L-Cit) have novel function to survive chickens to heat stress. L-Leu was injected in fertile broiler eggs and the obtained broilers were thermotolerant and their body weight gain was higher than the control group. On the other hand, not only synthetic L-Cit but also L-Cit enriched probiotics and watermelon rind juice, which is a natural source of L-Cit, efficiently reduced body temperature. In these studies, we have also explored the metabolic changes and possible mechanisms of L-Leu and L-Cit induced thermoregulation. L-Leu caused lipid metabolism imprinting until the neonatal period of broiler chicks. In terms of amino acid metabolism, among different changes brain GABA concentration was higher in L-Leu treated heat-exposed broilers compared to the control. L-Cit caused to change metabolic hormones and amino acid metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
深刻化する地球温暖化によって食料生産は危機に直面している。本調査結果は、ニワトリの耐暑性向上によって持続可能な食糧生産の実現に寄与するものと考えられる。調査対象のアミノ酸は、身近なものであることから、環境・人体への悪影響なく、シトルリンのように農副産物に多く含有するものを利用することで循環型の持続可能な食料生産につながるものと考えられる。また、これらアミノ酸による暑熱ストレス軽減効果の他家畜への利用、さらにはヒトへの適用なども含めてその端緒となりうるものである。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Effects of in ovo feeding of L-leucine on amino acids metabolism and heat-shock protein-70, and -90 mRNA expression in heat-exposed chicks.2019
Author(s)
Han, G., Yang, H., Ikeda, H., Wang, Y., Zhang, R., Tashiro, K., Bungo, T., Furuse, M. and Chowdhury, V.S.
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Journal Title
Poultry Science
Volume: 98
Pages: 1243-1253
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] In ovo administration of L-leucine: a novel approach to affording thermotolerance in broiler chicks2019
Author(s)
Han, G., Yang, H., Tashiro, K., Bungo, T., Furuse, M., Chowdhury, V.S.
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Journal Title
Reviews on Animal Nutrition and Metabolism
Volume: 63
Pages: 1-14
NAID
Related Report
Peer Reviewed
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[Presentation] Oral Administration of L-Citrulline Affords Thermotolerance in Heat-Exposed Broilers2018
Author(s)
Chowdhury, VS., Han, G., Shirashi, J., Sugino, T., Furuse, M., Bungo, T.
Organizer
Asian Australasian Animal Production Congress
Related Report
Int'l Joint Research
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