Pathology of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis)

• Project/Area Number: 18K19277
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 42:Veterinary medical science, animal science, and related fields
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: KOHARA Michinori 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 特任研究員 (10250218)
• Project Period (FY): 2018-06-29 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ツパイ / 乳がん / 遺伝性 / 自然発症乳がんモデル

Outline of Final Research Achievements

Breast cancer has a high incidence in our country and its control is urgently needed. The tupai is a small mammal with genetic information similar to that of humans. Since mammary tumors in tupai have a structure similar to that of human papillary adenocarcinoma, it was expected to be an excellent model for the development of breast cancer. Histopathological examination of spontaneous mammary tumors in Tupai revealed that the mammary gland tumors were often ductal papillary carcinomas, and that the morphology and pathology of the tumors were very similar to those of human papillary adenocarcinomas. Cytological examination confirmed that the tumor was an epithelial malignant tumor.

Academic Significance and Societal Importance of the Research Achievements

ツパイはツパイ目ツパイ科に属す、体重が約150グラムの小型哺乳動物で、近年まで原猿類に分類されていた。また、ツパイは人に近い遺伝情報を持っており、ヒトとチンパンジーにしか感染しないB型肝炎ウイルスの感染受容体がツパイの肝細胞から同定されている。ツパイの乳腺の生理学的特徴と発育などはヒトに類似している。平均発生月齢は2年3ヶ月で、一番早くは10ヶ月齢に見られた。このことから、ツパイの自然発症乳腺腫瘍は遺伝性のものが多く、若年性のものもあることが示された。本研究から得られたこれらの新たな知見を元に、早期診断、予防、治療法開発に資する可能性が示された。

Research Products

• [Journal Article] Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew) (2020)
  • Author(s): Chi Hai-Ying, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamu Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara
  • Journal Title: PLoS One Volume: 15(5) Issue: 5 Pages: e0233232-e0233232
  • DOI: 10.1371/journal.pone.0233232
  • Peer Reviewed / Open Access
• [Journal Article] Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri) (2019)
  • Author(s): Takahiro Sanada, Fumihiko Yasui, Tomoko Honda, Mohammad Enamul Hoque Kayesh, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, and Michinori Kohara
  • Journal Title: Virology Volume: 529 Pages: 101-110
  • DOI: 10.1016/j.virol.2019.01.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Pathophysiology of hepatitis C virus and animal model (2018)
  • Author(s): Mohammad Enamul Hoque Kayesh et al.
  • Organizer: The12 th China-Japan International Conference of Virology
  • Int'l Joint Research
• [Presentation] 新規HBs-Lh抗原及びCVP基剤併用経鼻投与により遺伝子型交差反応性の高い中和抗体及びlgA抗体の産生が誘導出来る (2018)
  • Author(s): 小原 道法, 真田 崇弘, Kayesh MEH, 小原 恭子, 山本 直樹, 日浅 陽一, 長谷川 秀樹, 杉山真也, 郷 保正, 宮崎 隆, 溝上 雅史
  • Organizer: 第22回日本ワクチン学会学術集会
• [Remarks] 公益財団法人東京都医学総合研究所 感染制御プロジェクト
  • URL: http://www.igakuken.or.jp/project/detail/infectious.html