| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It is believed that the only genetic information transmitted from parents to offspring is usually DNA sequence information. However, it has been reported that environmental and other influences on the fetus can be passed on to the next generation. Since DNA is known to undergo methylation modification, it is thought to be a promising source of information other than base sequences to be transmitted to the next generation. Primordial germ cells (PGCs) undergo erasure of DNA methylation, before sperm ad oocytes start to develop. This project aim to make a method to manipulate expression level of UHRF1 in PGCs; UHRF1 is a protein involved in maintenance of DNA methylation by recruiting DNMT1 to the replication foci.
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