Mechanism involved in the biosynthesis of a sex-inducing substance in the planarian Dugesia ryukyuensis
| Project/Area Number |
18K19318
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | プラナリア / 有性生殖 / 無性生殖 / 生殖様式転換 / 共生細菌 |
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| Outline of Final Research Achievements |
Metazoans occasionally switch their mode of reproduction on the basis of environmental changes, life cycle phase, or both. However, the mechanisms underlying the switch from an asexual to a sexual mode of reproduction and vice versa are poorly understood. We established an assay system for sexualization in the planarian Dugesia ryukyuensis. In this assay system, asexual worms were stimulated to develop hermaphroditic reproductive organs by being fed sexually mature planarians. This means that sexually mature planarians contain sex-inducing substances. In the current study, using this assay system, we suggested a mechanism involved in the biosynthesis of a sex-inducing substance.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では扁形動物プラナリアに、宿主の生殖細胞の分化を抑制して「無性化」を促進する共生細菌が存在し有性化を阻害する、いわゆる「性殺し(有性排除)」という仕組みを新たな概念として提案することができた。将来的にハエやマウスなどの生殖細胞分化でも検証することで、生殖細胞を誘導する仕組みに共生細菌の存在が関与しているという、生物学全体にインパクトを与える新しい共通原理を提案できるかもしれない。
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Report
(4 results)
Research Products
(11 results)
