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Elucidation of a network between brain and testis

Research Project

Project/Area Number 18K19322
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Uesaka Naofumi  東京大学, 大学院医学系研究科(医学部), 講師 (70597624)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords精巣 / カルシウム / 脳 / in vivo / イメージング / 活動操作 / 精子形成
Outline of Final Research Achievements

There are many unclear points for mechanisms of spermatogenesis. In this study, I examined the hypothesis that calcium regulates spermatogenesis. I applied calcium imaging and optogenetics to observe and manipulate calcium activity of testicular cells in real time in vivo. I could develop a new in vivo calcium imaging method and a activity manipulation method in mouse testis which could image and manipulate the calcium activity of cells in vivo at single cell level and multicolor. I also found a molecule mechanism which drives calcium activity in the testicular cells and that calcium activity might be involved in spermatogenesis.

Academic Significance and Societal Importance of the Research Achievements

生殖細胞は生物の遺伝情報を次世代へ伝える細胞であり、進化に関わるロマンあふれる細胞である。本研究で生殖細胞である精子に注目し新規イメージング技術を開発したことにより、脳が精子形成を制御するメカニズムを明らかにできる可能性が出てきた。この研究の成果は、生物が次世代に情報を伝える仕組みやその結果起こる進化の仕組みを解明する上で重要な知見となる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus2020

    • Author(s)
      Saito Ryo、Koebis Michinori、Nagai Taku、Shimizu Kimiko、Liao Jingzhu、Wulaer Bolati、Sugaya Yuki、Nagahama Kenichiro、Uesaka Naofumi、Kushima Itaru、Mori Daisuke、Maruyama Kazuaki、Nakao Kazuki、Kurihara Hiroki、Yamada Kiyofumi、Kano Masanobu、Fukada Yoshitaka、Ozaki Norio、Aiba Atsu
    • Journal Title

      Translational Psychiatry

      Volume: 10 Issue: 1 Pages: 35-35

    • DOI

      10.1038/s41398-020-0723-z

    • URL

      https://pure.teikyo.jp/en/publications/ffaf265c-5861-4ce2-beba-82ea8b69cfa5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum2018

    • Author(s)
      Kano Masanobu、Watanabe Takaki、Uesaka Naofumi、Watanabe Masahiko
    • Journal Title

      The Cerebellum

      Volume: 17 Issue: 6 Pages: 722-734

    • DOI

      10.1007/s12311-018-0964-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum2020

    • Author(s)
      Takaki Watanabe1, 2,Honoka Suzuki1,Kazuto Sakoori1,Shutaro Inoue1,Tsubasa Akamatsu1, Manabu Abe3,Kenji Sakimura3,Naofumi Uesaka1, 2,Masanobu Kano1,
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 精神疾患関連エピジェネティクス因子の欠損が、マウス内側前頭前野錐体細胞への興奮性シナプス入力の減弱と異常行動を引き起こす2019

    • Author(s)
      濱 健一郎 / 佐郡 和人 / 渡邉 貴樹 / 古戎 道典 / 上阪 直史 / 饗場 篤 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Related Report
      2019 Annual Research Report
  • [Presentation] 発達期小脳において、アルドラーゼC陽性プルキンエ細胞の登上線維シナプス刈り込みはアルドラーゼC陰性プルキンエ細胞よりも遅れ、ホスホリパーゼC β3を必要とする2019

    • Author(s)
      渡邉 貴樹 / 賴 友梨恵 / 鈴木 穂香 / 赤松 翼 / 上阪 直史 / 狩野 方伸
    • Organizer
      第42回日本神経科学学会・新潟
    • Related Report
      2019 Annual Research Report
  • [Presentation] Activity-dependent synapse elimination in the developing cerebellum2019

    • Author(s)
      Naofumi Uesaka, Tzu-Huei Kao, Masanobu Kano
    • Organizer
      FAOPS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor2019

    • Author(s)
      Kenichiro Nagahama, Kazuto Sakoori, Takaki Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum2019

    • Author(s)
      Kushibe Kyoko, Celine Mercier, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 102019

    • Author(s)
      Takaki Watanabe, Shutaro Inoue, Tsubasa Akamatsu, Honoka Suzuki, Manabu Abe, Kenji Sakimura, Naofumi Uesaka, Masanobu Kano
    • Organizer
      FAOPS2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retrograde BDNF signaling required for synapse elimination in the developing cerebellum2018

    • Author(s)
      Myeong Jeong Choo:Naofumi Uesaka:Masahiko Watanabe:Kenji Sakimura:Masanobu Kano:
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Impaired Synapse Development in Mouse Medial Prefrontal Cortex by Deletion of a Histone-Modifying Enzyme Implicated in Psychiatric Disorder2018

    • Author(s)
      Kenichiro Nagahama: Kazuto Sakoori:Takaki Watanabe:Naofumi Uesaka:Masanobu Kano
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Roles of synaptic transmission in climbing fiber to Purkinje cell synapse elimination during postnatal cerebellar development2018

    • Author(s)
      Tzu-Huei Kao:Kyoko Matsuyama:Naofumi Uesaka:Masanobu Kano
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Remarks] リサーチマップ

    • URL

      https://researchmap.jp/keichan3sai/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-07-25   Modified: 2022-01-27  

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