• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel functions of plant steroid hormone brassinosteroid as a reproductive hormone

Research Project

Project/Area Number 18K19333
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
Research InstitutionNagoya University

Principal Investigator

Higashiyama Tetsuya  名古屋大学, 理学研究科(WPI), 教授 (00313205)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords植物ステロイドホルモン / ブラシノステロイド / 花粉 / 植物生殖 / シグナル伝達
Outline of Final Research Achievements

Brassinosteroid (BR) had activity to activate Arabidopsis pollen tubes, stigmas/styles, and ovules, by changing gene expression profiles. As downstream molecules of BR signaling in the style, novel factors were shown as significant. In pollen tubes, knockout of the BR receptor BRI1 and its homologues BRL2 and BRL3 did not abolish activation by BR. This clearly indicates existence of unknown receptor of BR. An agonist and its derivatives were shown to have BR activity, which would provide a way to identify unknown receptor. A patent has been applied.

Academic Significance and Societal Importance of the Research Achievements

ブラシノステロイド(BR)が植物生殖における重要な生殖ホルモンであることを発見した。動植物において、ステロイド化合物が共通して生殖ホルモンとして働くことは興味深い。BRは雌雄の組織において大規模に遺伝子発現を変化させ、生殖を達成することがわかった。生殖過程で働く様々な有名な遺伝子が、BRにより発現が向上した。興味深いことに、花粉では、未知の受容体が存在することが示された。その同定にむけ、重要な研究になるとともに、今後ブラシノステロイドの起源にも迫ることが期待される。また栄養器官に影響をあたえず、生殖特異的なBRシグナルリング経路を人為的に制御することも可能と考えられる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] AtNOT1 Is a Novel Regulator of Gene Expression during Pollen Development2019

    • Author(s)
      Motomura Kazuki、Arae Toshihiro、Araki-Uramoto Haruka、Suzuki Yuya、Takeuchi Hidenori、Suzuki Takamasa、Ichihashi Yasunori、Shibata Arisa、Shirasu Ken、Takeda Atsushi、Higashiyama Tetsuya、Chiba Yukako
    • Journal Title

      Plant and Cell Physiology

      Volume: 61 Issue: 4 Pages: 712-721

    • DOI

      10.1093/pcp/pcz235

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KAKU4-mediated deformation of the vegetative nucleus controls its precedent migration over sperm cells in pollen tubes2019

    • Author(s)
      Chieko Goto, Kentaro Tamura, Satsuki Nishimaki, Naoki Yanagisawa, Kumi Matsuura-Tokita, Tetsuya Higashiyama, Daisuke Maruyama, and Ikuko Hara-Nishimura
    • Journal Title

      bioRxiv

      Volume: なし(プレプリントのため) Pages: 0-0

    • DOI

      10.1101/774489

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] ANTH domain-containing proteins are required for the pollen tube plasma membrane integrity via recycling ANXUR kinases2018

    • Author(s)
      Muro Keita、Matsuura-Tokita Kumi、Tsukamoto Ryoko、Kanaoka Masahiro M.、Ebine Kazuo、Higashiyama Tetsuya、Nakano Akihiko、Ueda Takashi
    • Journal Title

      Communications Biology

      Volume: 1 Issue: 1 Pages: 152-152

    • DOI

      10.1038/s42003-018-0158-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Key signalling molecules in pollen tube guidance2020

    • Author(s)
      Tetsuya Higashiyama
    • Organizer
      Symposium Down Under: Mechanisms controlling plant reproduction
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Live-Cell Analysis of Multi-Step Signaling in Pollen Tube Guidance2019

    • Author(s)
      Tetsuya Higashiyama
    • Organizer
      The 11th Tri-National Arabidopsis Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Key molecules of sexual reproduction identified by live-cell and synthetic-chemistry approaches2019

    • Author(s)
      Tetsuya Higashiyama
    • Organizer
      22nd Plant Biology Symposium: Plant Cell Dynamics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Receptor-like kinases in plant reproduction2019

    • Author(s)
      Tetsuya Higashiyama
    • Organizer
      International Symposium on Plant Receptor Kinases and Cell Signaling 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Key signalling molecules in plant reproduction: Re-discovery of a reproductive hormone2019

    • Author(s)
      Tetsuya Higashiyama
    • Organizer
      Woolhouse Lecture of John Innes Seminar(
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シロイヌナズナの有性生殖の ために雌雄細胞を活性化する鍵分子2019

    • Author(s)
      時田公美、上田彩果,北野浩之、伊藤英人、佐藤綾人、鈴木孝征、中野雄司、伊丹健一郎、東山哲也
    • Organizer
      第60回日本植物生理学会年会
    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] 花粉管成長調節剤2019

    • Inventor(s)
      東山哲也,時田公 美,伊丹健一郎,上 田彩果,他3名
    • Industrial Property Rights Holder
      東山哲也,時田公 美,伊丹健一郎,上 田彩果,他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-07-25   Modified: 2023-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi