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Discovery of novel peptide natural product with anti bacterial activities

Research Project

Project/Area Number 18K19388
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionTohoku University (2019-2020)
The University of Tokyo (2018)

Principal Investigator

Teigo Asai  東北大学, 薬学研究科, 教授 (60572310)

Project Period (FY) 2018-06-29 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords天然物化学 / 抗生物質 / ペプチド天然物 / 生合成 / 異種発現 / ゲノムマインング / 天然物 / 糸状菌 / ゲノムマイニング / 活性天然物 / 非リボソーム型ペプチド合成酵素 / ペプチド / 二次代謝物 / 麹菌
Outline of Final Research Achievements

Peptide natural products are promising source for antibiotics. Therefore, discovery of novel natural peptide natural products is important for drug development. In this research, we aimed to discover novel peptide natural products based on genome mining and heterologous expression of Aspergillus oryzae. Genome mining enabled us to find a biosynthetic gene cluster that may code novel natural depsipeptide in a Chaetomium fungi. Reconstruction of the cluster in Aspergillu oryzae gave us a novel depsipeptide as expected. The structure of the depsipeptide was fully determined by spectral analyses and chemical conversion approach.

Academic Significance and Societal Importance of the Research Achievements

本研究は、糸状菌のゲノム情報から合理的に新しいペプチド天然物を獲得する方法を提示し、実際に、新規デプシペプチドの獲得に成功した。ペプチド天然物は抗生物質の重要な探索源であり、本研究成果は、新しい抗生物質の開発に貢献することが期待される。様々な生物のゲノム上には、膨大な数のペプチド天然物が眠っている。本研究を拡大することで、今後数多くの抗生物質シーズを開拓できることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Synthetic biology based construction of biological activity-related library focused on fungal decalin-containing diterpenoid pyrones2020

    • Author(s)
      1.Tsukada K, Shinki S, Kaneko A, Murakami K, Irie K, Murai M, Miyoshi H, Dan S, Kawaji K, Hayashi H, Kodama E, Hori A, Salim E, Kuraishi T, Hirata N, Kanda Y, Asai T.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1830-1830

    • DOI

      10.1038/s41467-020-15664-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome Mining-Based Discovery of Fungal Macrolides Modified by glycosylphosphatidylinositol (GPI)?Ethanolamine Phosphate Transferase Homologues2020

    • Author(s)
      Morishita Yohei、Aoki Yu、Ito Mei、Hagiwara Daisuke、Torimaru Kensho、Morita Daichi、Kuroda Teruo、Fukano Hanako、Hoshino Yoshihiko、Suzuki Masato、Taniguchi Tohru、Mori Keiji、Asai Teigo
    • Journal Title

      Organic Letters

      Volume: 22 Issue: 15 Pages: 5876-5879

    • DOI

      10.1021/acs.orglett.0c01975

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Chaetomium属菌のゲノム上にコードされた新規デプシペプチドの獲得2021

    • Author(s)
      本間悠人、森下陽平、塚田健人、浅井禎吾
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Post-genomic discovery of fungal natural products based on genome mining and heterologous expression2020

    • Author(s)
      Teigo Asai
    • Organizer
      Cutting-edge natural product chemistry -next generation biomolecule redesign-
    • Related Report
      2019 Research-status Report
  • [Presentation] 糸状菌ゲノム情報を活用するポストゲノム型天然物探索研究2019

    • Author(s)
      浅井禎吾
    • Organizer
      第102回日本細菌学会関東支部総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 糸状菌ゲノム情報に基づくポストゲノム型天然物探索研究2019

    • Author(s)
      浅井禎吾
    • Organizer
      第 66 回日本放線菌学会学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新たな医薬資源を開拓する糸状菌ポストゲノム型天然物探索研究2019

    • Author(s)
      浅井禎吾
    • Organizer
      第139回日本薬学会年会シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 麹菌異種発現を基盤とする天然物探索研究2018

    • Author(s)
      浅井禎吾
    • Organizer
      糸状菌相互応答学セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Discovery of natural products based on re-construction and re-designing of fungal cryptic biosynthetic gene clusters in Aspergillus oryzae2018

    • Author(s)
      Teigo Asai
    • Organizer
      Japanese-German Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2018-07-25   Modified: 2022-01-27  

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