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New nanoparticle for neurodiagnosis of "diagnosing pain"

Research Project

Project/Area Number 18K19413
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionShowa University

Principal Investigator

MURAYAMA SHUHEI  昭和大学, 薬学部, 講師 (50549649)

Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords分析科学 / ナノ粒子 / DDS / 生体イメージング / DDS / 分析化学 / ナノ粒子ゲル / イメージング
Outline of Final Research Achievements

In this study, using the mesh structure of nanogel, a complex containing heavy metals is used as a contrast agent in a state of being isolated and protected from the in-vivo environment, and the contrast medium is quickly and surely used in a safe form from the in-vivo.
With a two-step approach of excretion, we actually made a prototype of nanogel with reduced toxicity with the aim of developing a low-toxicity renal excretory nanogel neurodiagnosis probe platform and evaluating pain using it. In fact, we succeeded in minimally invasive imaging of rat nerves.

Academic Significance and Societal Importance of the Research Achievements

現在、病院などのMRIで生体内部を観察するために用いられている薬は、重金属由来のものであり、毒性の高い物が用いられている。高齢化社会が進む近い将来、大きな問題になる慢性疼痛について、観察する手段としてそのような薬を繰り返し用いると、歩行できなくなる位の酷い腫れなどが起こるとラットでの実験結果から予想され、用いることは好ましくないが、ナノ粒子を用いて改良することで、そのような問題が解決できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (11 results)

  • [Journal Article] Method for Controlling Intracellular Protein Activity Using Photoresponsive Nanoparticles2022

    • Author(s)
      Murayama Shuhei、Kono Noriaki、Takaki Takashi、Kato Masaru
    • Journal Title

      Sensors and Materials

      Volume: 34 Issue: 3 Pages: 937

    • DOI

      10.18494/SAM.2021.3585

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2022-03-03
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging2021

    • Author(s)
      Okubo Kyohei、Takeda Ryuta、Murayama Shuhei、Umezawa Masakazu、Kamimura Masao、Osada Kensuke、Aoki Ichio、Soga Kohei
    • Journal Title

      Science and Technology of Advanced Materials

      Volume: 22 Issue: 1 Pages: 160-172

    • DOI

      10.1080/14686996.2021.1887712

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Minimally invasive manganese‐enhanced magnetic resonance imaging for the sciatic nerve tract tracing used intra‐articularly administrated dextran?manganese encapsulated nanogels2019

    • Author(s)
      Eguchi Yawara、Murayama Shuhei、Kanamoto Hirohito、Abe Koki、Miyagi Masayuki、Takahashi Kazuhisa、Ohtori Seiji、Aoki Ichio
    • Journal Title

      JOR SPINE

      Volume: 2 Issue: 2

    • DOI

      10.1002/jsp2.1059

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photodegradable Nanoparticles for Functional Analysis of Intracellular Protein2018

    • Author(s)
      Murayama Shuhei、Karasawa Koji、Kato Masaru
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 31 Issue: 1 Pages: 71-74

    • DOI

      10.2494/photopolymer.31.71

    • NAID

      130007481550

    • ISSN
      0914-9244, 1349-6336
    • Year and Date
      2018-06-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative2018

    • Author(s)
      Araki Takeru、Fuchi Yasufumi、Murayama Shuhei、Shiraishi Ryoma、Oyama Tokimi、Aso Mariko、Aoki Ichio、Kobayashi Shigeki、Yamada Ken-ichi、Karasawa Satoru
    • Journal Title

      Nanomaterials

      Volume: 8 Issue: 10 Pages: 782-782

    • DOI

      10.3390/nano8100782

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enrichment of liposomal nanomedicines using monolithic solid phase extraction discs following preactivation with bivalent metal ion solutions2018

    • Author(s)
      Watanabe Ayako、Karasawa Koji、Murayama Shuhei、Sano Yoshihiro、Takagi Mio、Yamamoto Eiichi、Murata Shigeo、Kato Masaru
    • Journal Title

      Journal of Chromatography A

      Volume: 1564 Pages: 224-227

    • DOI

      10.1016/j.chroma.2018.06.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging2018

    • Author(s)
      Morishita Kosuke、Ueki Shoji、Fuchi Yasufumi、Murayama Shuhei、Kaneko Tomoyo、Narita Nozomi、Kobayashi Shigeki、Hirai Go、Aoki Ichio、Karasawa Satoru
    • Journal Title

      ACS Applied Nano Materials

      Volume: 1 Issue: 12 Pages: 6967-6975

    • DOI

      10.1021/acsanm.8b01774

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] ナノ粒子によるカタラーゼの安定化と持続的な抗酸化活性2022

    • Author(s)
      佐々木陸杜、村山周平、加藤大
    • Organizer
      日本薬学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高密度ナノ粒子による デュアル酵素の安定化と 機能制御法の開発2022

    • Author(s)
      坂口創麻、村山周平、加藤大
    • Organizer
      日本薬学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] カタラーゼ内包ナノ粒子による 細胞内抗酸化活性制御2021

    • Author(s)
      村山周平、佐々木陸杜、坂口創麻、加藤大
    • Organizer
      BMAS
    • Related Report
      2021 Annual Research Report
  • [Presentation] 光応答性ナノ粒子による機能性分子放出量の精密制御法2020

    • Author(s)
      村山 周平、山﨑 詩乃、唐沢 浩二、 加藤 大
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] ナノ粒子を用いてタンパク質を精密に機能させる方法2020

    • Author(s)
      出川朱花 村山周平 加藤大
    • Organizer
      新アミノ酸分析研究会第10回学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 光応答性ナノ粒子による細胞内タンパク質の『数量』制御法開発2019

    • Author(s)
      村山周平、河野典秋、佐々木彩香、出川朱花、唐沢浩二、加藤大
    • Organizer
      バイオメディカル分析科学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 光応答性ナノ粒子によるタンパク質放出量の精密制御法開発2019

    • Author(s)
      村山周平、河野典秋、佐々木彩香、出川朱花、唐沢浩二、加藤 大
    • Organizer
      新アミノ酸分析研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] ゲルの網目構造が内包した生理活性物質の放出に与える影響2019

    • Author(s)
      佐々木 彩香, 村山 周平, 唐沢 浩二, 加藤 大
    • Organizer
      日本薬学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光を利用した細胞内タンパク質の 『量的調節』と細胞の機能制御2019

    • Author(s)
      河野 典秋, 村山 周平, 唐沢 浩二, 加藤 大
    • Organizer
      日本薬学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 細胞内分析に向けた ソフトナノ粒子プローブ2018

    • Author(s)
      村山周平
    • Organizer
      第11回NanoBio若手ネットワーキングシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] ミトコンドリアへ送達される ナノ粒子の開発 ~細胞内のナノ粒子の行き先を制御する~2018

    • Author(s)
      村山周平、小林修輔、竹内涼、小倉麻美、茂野由佳、 山﨑詩乃、唐沢浩二、加藤大
    • Organizer
      BMAS2018
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2023-01-30  

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