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Analysis of molelular mechanism underlying retinal fovea formation using zebra finch

Research Project

Project/Area Number 18K19427
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 48:Biomedical structure and function and related fields
Research InstitutionOsaka University

Principal Investigator

Furukawa Takahisa  大阪大学, 蛋白質研究所, 教授 (50260609)

Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords黄斑 / 中心窩 / 網膜 / キンカチョウ / 視覚 / 細胞形態
Outline of Final Research Achievements

In humans, high-acuity central vision depends on the fovea, which is a small central pit structure formed at the center of the macula in the retina. Retinal degenerative diseases affecting the fovea, including age-related macular degeneration and Stargardt's disease, lead to blindness. In the current study, we einvestigated foveal development using the zebra finch retina at several developmental stages. We carried out comparative analysis of gene expression profiles between the fovea and the periphery in the developing zebra finch retina during foveal development. We successfully identified a candidate gene involved in fovea development, which may function in cell and tissue morphogenesis.

Academic Significance and Societal Importance of the Research Achievements

我々の高精度の視覚が成立するためには、網膜の黄斑の中心に形成される窪み構造である中心窩が重要な役割を果たしている。本成果は、今まで未解明であった、中心窩の発生の分子メカニズムの一端を明らかにするとともに、黄斑変性やスターガルト病といった失明につながるヒト網膜変性疾患の診断法や治療技術の開発の基盤となると期待される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (6 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells.2020

    • Author(s)
      Furukawa T, Ueno A, Omori Y
    • Journal Title

      Cell Mol Life Science

      Volume: 77 Issue: 7 Pages: 1251-1266

    • DOI

      10.1007/s00018-019-03324-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.2020

    • Author(s)
      5).Yamamoto H, Kon T, Omori Y, Furukawa T
    • Journal Title

      Cell Reports30

      Volume: 30 Issue: 3 Pages: 658-671.e5

    • DOI

      10.1016/j.celrep.2019.12.072

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinal ON and OFF pathways contribute to initial optokinetic responses with different temporal characteristics2020

    • Author(s)
      Sugita Yuko、Miura Kenichiro、Furukawa Takahisa
    • Journal Title

      European Journal of Neuroscience

      Volume: - Issue: 4 Pages: 3160-3165

    • DOI

      10.1111/ejn.14697

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin and evolution of the Rax homeobox gene by comprehensive evolutionary analysis2020

    • Author(s)
      Kon Tetsuo、Furukawa Takahisa
    • Journal Title

      FEBS Open Bio

      Volume: - Issue: 4 Pages: 657-673

    • DOI

      10.1002/2211-5463.12832

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.2020

    • Author(s)
      Mizobuchi K, Hayashi T, Katagiri S, Kim E, Ishiba Y, Watanabe S, Furukawa T, Nakano T
    • Journal Title

      Doc Ophthalmology

      Volume: - Issue: 2 Pages: 195-204

    • DOI

      10.1007/s10633-020-09764-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cul3‐Klhl18 ubiquitin ligase modulates rod transducin translocation during light‐dark adaptation2019

    • Author(s)
      Chaya Taro、Tsutsumi Ryotaro、Varner Leah Rie、Maeda Yamato、Yoshida Satoyo、Furukawa Takahisa
    • Journal Title

      The EMBO Journal

      Volume: 38 Issue: 23

    • DOI

      10.15252/embj.2018101409

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ubiquitin-dependent regulation of transducin translocation during light and dark adaptation2019

    • Author(s)
      Takahisa Furukawa
    • Organizer
      ARVO2019 Annual Meeting
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular control of light-dark adaptation in the retina2019

    • Author(s)
      Takahisa Furukawa, Taro Chaya, Ryotaro Tsutsumi, Yamato Maeda
    • Organizer
      KSBMB International Conference 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 視細胞リボンシナプスは光刺激に対する順応を調整する働きを持つ2019

    • Author(s)
      杉田 祐子
    • Organizer
      NEURO2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ubiquitin-dependent regulation of ciliary transport during light and dark adaptation in retinal photoreceptor cells2019

    • Author(s)
      Taro Chaya, Ryotaro Tsutsumi, Leah Rie Varner, Yamato Maeda, Takahisa Furukawa
    • Organizer
      Cold Spring Harbor Asia Cilia & Centrosomes
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular mechanisms of light-dark adaptation in the retina2019

    • Author(s)
      Takahisa Furukawa, Taro Chaya
    • Organizer
      Retinal workshop at OIST 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] キンカチョウ網膜を用いた中心窩形成の分子メカニズムの解明2018

    • Author(s)
      杉山剛文, 大森義裕, 今鉄男, 吉原大貴, 鈴木穣, 安部健太郎, 渡邉大, 古川貴久
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Research-status Report
  • [Remarks] 蛋白質研究所分子発生学研究室 業績集

    • URL

      http://www.protein.osaka-u.ac.jp/furukawa_lab/achievements.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-07-25   Modified: 2021-12-27  

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