Study on the effects of amino acid availability on life span and the underlying molecular mechanisms
| Project/Area Number |
18K19429
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 48:Biomedical structure and function and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大垣 隆一 大阪大学, 医学系研究科, 助教 (20467525)
奥田 傑 大阪大学, 医学系研究科, 助教 (50511846)
岡西 広樹 大阪大学, 医学系研究科, 助教 (70792589)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | アミノ酸 / トランスポーター / 寿命 |
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| Outline of Final Research Achievements |
Prolongation of life span by dietary restrictions has been reported in many species. Its fundamental mechanisms behind have been supposed to be in common among species. This research used C. elegans as a model animal and demonstrated that it is possible to restrict whole body amino acid availability by double knockout of an intestinal amino acid transporter with broad substrate selectivity and an intestinal oligopeptide transporter. Furthermore, this research showed that, in this animal model, the restriction of whole-body amino acid availability results in the prolongation of life span.
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| Academic Significance and Societal Importance of the Research Achievements |
食餌制限による寿命の延長効果についてのこれまでの解析では、食餌中から特定の成分のみを厳密に選択的に除くことは困難であり、食餌制限がもたらす寿命への影響を摂取カロリーの減少の影響として一括りに捉えることが多かった。本研究は、線虫を用い、腸管の複数のトランスポーターのノックアウトにより、個体のアミノ酸アベイラビリティを大幅に低下させるモデル系を確立し、アミノ酸栄養の制限による個体寿命の延長を実証したものである。その分子機構の解明は、寿命研究に新たな方向性を提示するものと期待される。
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma.2020
Author(s)
Maimaiti M, Sakamoto S, Yamada Y, Sugiura M, Rii J, Takeuchi N, Imamura Y, Furihata T, Ando K, Higuchi K, Xu M, Sazuka T, Nakamura K, Kaneda A, Kanai Y, Kyprianou N, Ikehara Y, Anzai N, Ichikawa T.
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 1292-1292
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters2019
Author(s)
Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.
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Journal Title
British Journal of Pharmacology
Volume: 176
Issue: S1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] 次世代シークエンス解析によるシスチン尿症患者新規遺伝子変異の同定と欧米遺伝子型分類の日本人患者妥当性の検討2019
Author(s)
坂本 信一, 納谷 幸男, 茂田 安弘, 藤村 正亮, 阿波 裕輔, 二瓶 直樹, 植田 健, 金井 好克, 三上 和男, 赤倉 功一郎, 正井 基之, 山口 邦雄, 野積 邦義, 伊藤 晴夫, 池原 譲, 安西 尚彦, 市川 智彦
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Journal Title
日本尿路結石症学会誌
Volume: 17
Pages: 105-110
Related Report
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[Presentation] PEPT1-targeted boron delivery for boron neutron capture therapy using BPA-containing dipeptide2019
Author(s)
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
Organizer
第92回 日本薬理学会年会
Related Report
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[Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, are transported by oligopeptide transporter2018
Author(s)
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
Organizer
18th World congress of basic and clinical pharmacology
Related Report
Int'l Joint Research
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