Detection of commensal bacteria which prevent fungal infections

• Project/Area Number: 18K19437
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 49:Pathology, infection/immunology, and related fields
• Research Institution: Chiba University
• Principal Investigator: SAIJO SHINOBU 千葉大学, 真菌医学研究センター, 准教授 (60396877)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: サイトカイン / 真菌感染防御 / 感染免疫 / 常在細菌叢 / 真菌感染 / C型レクチン / 感染防御 / 遺伝子改変動物 / 常在菌 / 動物モデル

Outline of Final Research Achievements

Candida albicans is known as one of the commensal fungi in humans. The fungus is also known as a causative agent that drives life-threatening invasive infections. Here we show that colonization of C. albicans in the guts induce host protection against systemic C. albicans infection.

Academic Significance and Societal Importance of the Research Achievements

近年、社会の高齢化に伴い真菌感染症をはじめとした日和見感染症が大きな問題となっている。本研究では、全身性真菌感染防御機構として、常在性真菌が重要な役割を担っていることを明らかにした。この結果により、真菌感染に対する新たな治療戦略を導ける可能性が示唆された。

Research Products

• [Journal Article] Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses (2019)
  • Author(s): Suematsu, R. Miyamoto, T. Saijo, S. Yamasaki, S. Tada, Y. Yoshida, H. Miyake, Y.
  • Journal Title: Int J Mol Sci Volume: 45 Issue: 45 Pages: 16776-16788
  • DOI: 10.1074/jbc.ra119.009835
  • Peer Reviewed / Open Access
• [Journal Article] Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract (2019)
  • Author(s): Matsuo K, Haku A, Bi B, Takahashi H, Kamada N, Yaguchi T, Saijo S, Yoneyama M, Goto Y.
  • Journal Title: Microbiology and Immunology Volume: - Issue: 5 Pages: 155-163
  • DOI: 10.1111/1348-0421.12680
  • NAID: 40021927492
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dectin-2-Mediated Signaling Leads to Delayed Skin Wound Healing through Enhanced Neutrophilic Inflammatory Response and Neutrophil Extracellular Trap Formation. (2019)
  • Author(s): Miura T, Kawakami K, Kanno E, Tanno H, Tada H, Sato N, Masaki A, Yokoyama R, Kawamura K, Kitai Y, Takagi N, Yamaguchi K, Yamaguchi N, Kyo Y, Ishii K, Imai Y, Saijo S, Iwakura Y, Tachi M.
  • Journal Title: J Invest Dermatol Volume: 139(3) Issue: 3 Pages: 702-711
  • DOI: 10.1016/j.jid.2018.10.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T(reg) cells through modification of the intestinal microbiota. (2018)
  • Author(s): Tang C, Kakuta S, Shimizu K, Kadoki M, Kamiya T, Shimazu T, Kubo S, Saijo S, Ishigame H, Nakae S, Iwakura Y.
  • Journal Title: Nat Immunol. Volume: 19 Issue: 7 Pages: 755-765
  • DOI: 10.1038/s41590-018-0134-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop. (2018)
  • Author(s): Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
  • Journal Title: J Immunol. Volume: 201 Issue: 1 Pages: 167-182
  • DOI: 10.4049/jimmunol.1701157
  • Peer Reviewed / Open Access