| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The supply of oxygen and nutrients through blood vessels is necessary for the growth of tumor tissue. Therefore, anti-angiogenesis drugs that suppress the formation of tumor blood vessels have been developed. In particular, inhibitors of VEGF, the central molecule of angiogenesis, have been developed. However, these drugs only slightly prolong the survival of cancer patients. In this study, we analyzed the microenvironment involved in the induction of tumor angiogenesis in order to clarify the reason why the therapeutic effect of angiogenesis inhibitors is not sufficient. Analysis of the process of tumor angiogenesis using an in vivo imaging system revealed that changes in the tumor microenvironment induce sprouting of tumor angiogenesis.
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