Analysis of neural dynamics during courtship learning through development of bioluminescence recording system
| Project/Area Number |
18K19502
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 51:Brain sciences and related fields
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kazama Hokto 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (90546574)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 発光計測 / 自由行動 / 嗅覚受容細胞 / 中枢神経細胞 / 血液脳関門 / ショウジョウバエ / フェロモン / 発光 / ドーパミン細胞 / エクオリン |
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| Outline of Final Research Achievements |
Neural mechanisms underlying active acquisition of sensory information during social behavior have largely remained elusive due to the lack of technology that simultaneously monitors the neural activity and movement of freely behaving animals. In this study, we developed a system that non-invasively tracks the activity of specific type of neurons and movement of freely behaving fruit fly Drosophila by combining a bioluminescence probe, photomultiplier tubes, and thermography. Using this system, we uncovered a novel strategy and a neural mechanism that animals employ to communicate via pheromone signals.
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| Academic Significance and Societal Importance of the Research Achievements |
今回開発した発光バイオセンサーを用いたシステムは、自然環境により近い状況で動物を自由に行動させ、特定の神経細胞の活動を可視化できる利点がある。このようなアプローチにより、動物がどのようにして情報交換をするのかといったコミュニケーションの戦略や、どのようにして複数の同種を見分けるのかという個体認識のメカニズムの理解につながると期待できる。また、近年発展しているゲノム編集の技術と本システムを組み合わせることで、ハエに限らずさまざまな動物において広く社会的行動の神経基盤を解明できる可能性がひらけた。
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum2019
Author(s)
Toshiya Ando, Sayaka Sekine, Sachi Inagaki, Kazuyo Misaki , Laurent Badel, Hiroyuki Moriya, Mustafa M. Sami, Yuki Itakura, Takahiro Chihara, Hokto Kazama , Shigenobu Yonemura, Shigeo Hayashi
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Journal Title
Current Biology
Volume: 29
Issue: 9
Pages: 1512-1520
DOI
Related Report
Peer Reviewed
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