| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Precise mechanism of repeat-associated non-AUG (RAN) translation remains obscure. Selective inhibition of RAN translation would be a therapeutic target for C9orf72 FTLD/ALS.
In this study, we identified a candidate regulator of RAN translation. Ever since its identification, we have performed validation experiments from multiple aspects if the candidate indeed modulates RAN translation. Current experimental results support our conclusion.
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