Paradigm convergence of non-AUG translation and cellular stress response
Project/Area Number |
18K19515
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 52:General internal medicine and related fields
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Research Institution | Osaka University |
Principal Investigator |
Mori Kohji 大阪大学, 医学系研究科, 助教 (40775318)
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Project Period (FY) |
2018-06-29 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | RAN翻訳 / 認知症 / 細胞ストレス / non-AUG翻訳 / C9orf72 / ジペプチドリピートリピート / DPR / 細胞ストレス応答 / FTD / FTLD |
Outline of Final Research Achievements |
Precise mechanism of repeat-associated non-AUG (RAN) translation remains obscure. Selective inhibition of RAN translation would be a therapeutic target for C9orf72 FTLD/ALS. In this study, we identified a candidate regulator of RAN translation. Ever since its identification, we have performed validation experiments from multiple aspects if the candidate indeed modulates RAN translation. Current experimental results support our conclusion.
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Academic Significance and Societal Importance of the Research Achievements |
前頭側頭葉変性症という行動や言語の障害を引き起こす病気の仕組みを明らかにしようとする研究です。前頭側頭葉変性症の一部では、遺伝子上の特定の配列が異常に長く繰り返されることが原因となっている場合があり、この配列は未解明の特殊なメカニズムで毒性を持ったタンパク質へと翻訳されています。この研究では、細胞負荷の観点から、この特殊な翻訳の調整メカニズムの一端を明らかにし、将来の治療法開発の基盤となる知見を得ました。
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Renal Function is Associated with Blood Neurofilament Light Chain Level in Older Adults2020
Author(s)
Akamine S, Marutani N, Kanayama D, Gotoh S, Maruyama R, Yanagida K, Sakagami Y, Mori K, Adachi H, Kozawa J, Maeda N, Otsuki M, Matsuoka T, Iwahashi H, Shimomura I, Ikeda M, Kudo T
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 20350-20350
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA32020
Author(s)
Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Kamp F, Nuscher B, Edbauer D, Haass C
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Journal Title
Acta Neuropathologica
Volume: 139
Issue: 1
Pages: 99-118
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A protein quality control pathway regulated by linear ubiquitination2019
Author(s)
van Well EM, Bader V, Patra M, Sanchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, ,,,, Hartl FU, Tatzelt J, Winklhofer KF
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Journal Title
The EMBO Journal
Volume: 38
Issue: 9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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