Elucidation of molecular mechanisms of mitochondrial function by non-coding RNA
| Project/Area Number |
18K19519
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 52:General internal medicine and related fields
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| Research Institution | Kumamoto University |
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Principal Investigator |
Oike Yuichi 熊本大学, 大学院生命科学研究部(医), 教授 (90312321)
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| Project Period (FY) |
2018-06-29 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 長鎖ノンコーディングRNA / ノンコーディングRNA / ミトコンドリア / lncRNA |
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| Outline of Final Research Achievements |
In this study, we identified the target gene of CELR-X, a novel long non-coding RNA that activates mitochondrial machinery and clarified its molecular mechanism. In addition, human ortholog candidate CELR-X genes were identified and the systemic overexpressing mice were prepared for functional analysis in vivo. Furthermore, we investigated whether it is possible to suppress the aging-related disease by using adeno-associated virus to express CELR-X.
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢社会を迎えた本邦において老化関連疾患に対する対策が急務となっており、近年、ミトコンドリアの機能低下と老化関連疾患との関連が注目されている。本研究ではミトコンドリア機能活性化を有する新規長鎖ノンコーディングRNAであるCELR-Xの標的分子の同定と分子機構の解明、さらにヒトオルソログ候補遺伝子を同定した。本研究がミトコンドリア機能不全に起因する老化関連疾患の分子病態解明の基盤となれば、心不全、サルコペニアなどの老化関連疾患の新規治療法や予防法となりうる可能性もあり、社会的貢献度は極めて高いと言える。
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice2019
Author(s)
Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y
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Journal Title
Circulation Journal
Volume: 83
Issue: 2
Pages: 368-378
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2019-01-25
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.2019
Author(s)
Kurahashi R, Kadomatsu T, Baba M, Hara C, Itoh H, Miyata K, Endo M, Morinaga J, Terada K, Araki K, Eto M, Schmidt LS, Kamba T, Linehan WM, Oike Y.
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Journal Title
Cancer Science
Volume: 印刷中
Issue: 6
Pages: 1897-1908
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.2018
Author(s)
Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y.
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Journal Title
J Biol Chem
Volume: 293
Issue: 5
Pages: 1596-1609
DOI
Related Report
Peer Reviewed / Open Access
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