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Effect of Organ Communication on Liver Function upon the Liver Injury

Research Project

Project/Area Number 18K19537
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 53:Organ-based internal medicine and related fields
Research InstitutionNiigata University

Principal Investigator

Shuji Terai  新潟大学, 医歯学系, 教授 (00332809)

Co-Investigator(Kenkyū-buntansha) 上村 顕也  新潟大学, 医歯学総合病院, 講師 (00579146)
上野 将紀  新潟大学, 脳研究所, 教授 (40435631)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脳腸肝ネットワーク / 神経 / 臓器連関 / 臓器間ネットワーク / 肝臓 / 脳 / 腸 / 再生
Outline of Final Research Achievements

The development of therapeutic options to promote hepatic is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of inter-organ communication to liver regeneration have not been reported. Therefore, in this study, we examined the effect of neural relay on liver regeneration via activation of gastrointestinal hormone release from the gastrointestinal tract. Our results demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve from the brain, leading to activation of hormone release from the gastrointestinal tract and contributing to the liver regeneration.

Academic Significance and Societal Importance of the Research Achievements

急性、慢性肝障害モデルマウスにおける肝臓からの求心性自律神経がその肝障害のシグナル伝達に重要で、遠心性に伝達された自律神経シグナルが、消化管ホルモンであるセロトニンやグレリンの発現増加を介して肝臓の病態悪化を防ぐ、生体の恒常性維持のために機能していることが明らかとなった。様々な疾患に関与するとされる自律神経ネットワークの肝障害での関連が明らかとなった。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2020 2019 2018

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 4 results) Presentation (3 results)

  • [Journal Article] Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease.2020

    • Author(s)
      Nagoya T, Kamimura K, Inoue R, Ko M, Owaki T, Niwa Y, Sakai N, Setsu T, Sakamaki A, Yokoo T, Kamimura H, Nakamura Y, Ueno M, Terai S.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 32 Issue: 5

    • DOI

      10.1111/nmo.13799

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma2020

    • Author(s)
      Kamimura Kenya、Yokoo Takeshi、Abe Hiroyuki、Sakai Norihiro、Nagoya Takuro、Kobayashi Yuji、Ohtsuka Masato、Miura Hiromi、Sakamaki Akira、Kamimura Hiroteru、Miyamura Norio、Nishina Hiroshi、Terai Shuji
    • Journal Title

      Cancers

      Volume: 12 Issue: 2 Pages: 472-472

    • DOI

      10.3390/cancers12020472

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Rare Duodenal Carcinosarcoma: A Case Report and Literature Review2019

    • Author(s)
      Arao Yoshihisa、Kamimura Kenya、Ikemi Masatoshi、Takaki Masayuki、Takahashi Shunsaku、Seino Satoshi、Abe Hiroyuki、Kohisa Junji、Kato Takashi、Ajioka Yoichi、Terai Shuji
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 9 Pages: 1273-1278

    • DOI

      10.2169/internalmedicine.2094-18

    • NAID

      130007641496

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-05-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of Capsule Endoscopy and Double-balloon Enteroscopy for the Diagnosis of Multiple Carcinoid Tumors in the Small Intestine: Case Reports and a Literature Review2019

    • Author(s)
      Tominaga Kentaro、Kamimura Kenya、Yokoyama Junji、Terai Shuji
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 5 Pages: 655-659

    • DOI

      10.2169/internalmedicine.1700-18

    • NAID

      130007606549

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-03-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Esophageal Stenosis by Prostate Cancer Metastasis2019

    • Author(s)
      Kamimura Kenya、Shinagawa-Kobayashi Yoko、Mizuno Kenichi、Terai Shuji
    • Journal Title

      The American Journal of Gastroenterology

      Volume: 114 Issue: 4 Pages: 685-687

    • DOI

      10.14309/ajg.0000000000000185

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of molecular transition of hepatocellular carcinoma: a novel method to predict the initiation of metastasis2019

    • Author(s)
      Kamimura Kenya
    • Journal Title

      Stem Cell Investigation

      Volume: 6 Pages: 5-5

    • DOI

      10.21037/sci.2019.02.02

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH)2019

    • Author(s)
      Goto Ryo、Kamimura Kenya、Shinagawa‐Kobayashi Yoko、Sakai Norihiro、Nagoya Takuro、Niwa Yusuke、Ko Masayoshi、Ogawa Kohei、Inoue Ryosuke、Yokoo Takeshi、Sakamaki Akira、Kamimura Hiroteru、Abe Satoshi、Nishina Hiroshi、Terai Shuji
    • Journal Title

      FEBS Open Bio

      Volume: 9 Issue: 4 Pages: 643-652

    • DOI

      10.1002/2211-5463.12598

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients2019

    • Author(s)
      Kamimura Kenya、Sakamaki Akira、Kamimura Hiroteru、Setsu Toru、Yokoo Takeshi、Takamura Masaaki、Terai Shuji
    • Journal Title

      World Journal of Gastroenterology

      Volume: 25 Issue: 15 Pages: 1817-1827

    • DOI

      10.3748/wjg.v25.i15.1817

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Endocrine Neoplasia Type 1?Related Acute Pancreatitis2019

    • Author(s)
      Takahashi Shunsaku、Kamimura Kenya、Abe Hiroyuki、Watanabe Yukari、Hayashi Kazunao、Mizuno Kenichi、Yamamoto Takashi、Takeuchi Manabu、Natsui Masaaki、Terai Shuji
    • Journal Title

      Pancreas

      Volume: 48 Issue: 5 Pages: e35-e38

    • DOI

      10.1097/mpa.0000000000001267

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <p>Effective prevention of sorafenib-related vascular damage induced adverse events and maintenance of hepatic function by dried bonito broth and histidine</p>2019

    • Author(s)
      Sakai Norihiro、Kamimura Kenya、Shinagawa-Kobayashi Yoko、Nagoya Takuro、Niwa Yusuke、Ko Masayoshi、Setsu Toru、Sakamaki Akira、Yokoo Takeshi、Abe Satoshi、Kamimura Hiroteru、Sugitani Soichi、Yanagi Masahiko、Terai Shuji
    • Journal Title

      Cancer Management and Research

      Volume: Volume 11 Pages: 4437-4448

    • DOI

      10.2147/cmar.s201424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of sodium‐glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis‐related kidney disease2019

    • Author(s)
      Nagoya Takuro、Kamimura Kenya、Goto Ryo、Shinagawa‐Kobayashi Yoko、Niwa Yusuke、Kimura Atsushi、Sakai Norihiro、Ko Masayoshi、Nishina Hiroshi、Terai Shuji
    • Journal Title

      FEBS Open Bio

      Volume: 9 Issue: 12 Pages: 2016-2024

    • DOI

      10.1002/2211-5463.12734

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiprogrammed Cell Death-1 Immunotherapy-Related Secondary Sclerosing Cholangitis2018

    • Author(s)
      Ogawa Kohei、Kamimura Kenya、Terai Shuji
    • Journal Title

      Hepatology

      Volume: 69 Issue: 2 Pages: 914-916

    • DOI

      10.1002/hep.30189

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autonomic nervous system network and liver regeneration2018

    • Author(s)
      Kamimura Kenya、Inoue Ryosuke、Nagoya Takuro、Sakai Norihiro、Goto Ryo、Ko Masayoshi、Niwa Yusuke、Terai Shuji
    • Journal Title

      World Journal of Gastroenterology

      Volume: 24 Issue: 15 Pages: 1616-1621

    • DOI

      10.3748/wjg.v24.i15.1616

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of a neural relay on liver regeneration in mice: activation of serotonin release from the gastrointestinal tract2018

    • Author(s)
      Inoue Ryosuke、Kamimura Kenya、Nagoya Takuro、Sakai Norihiro、Yokoo Takeshi、Goto Ryo、Ogawa Kohei、Shinagawa-Kobayashi Yoko、Watanabe-Mori Yukari、Sakamaki Akira、Abe Satoshi、Kamimura Hiroteru、Miyamura Norio、Nishina Hiroshi、Terai Shuji
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 3 Pages: 449-460

    • DOI

      10.1002/2211-5463.12382

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of gastrointestinal hormone on liver regeneration via neuronal relay2019

    • Author(s)
      Kenya Kamimura, et al.
    • Organizer
      GUTS FORUM 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス肝線維化進展予防薬の探索及びレトロゾールによる線維化進展予防効果の検証2019

    • Author(s)
      上村顕也、他。
    • Organizer
      第105回日本消化器病学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NASHの病態への臓器間ネットワークの関与2019

    • Author(s)
      高昌良、他。
    • Organizer
      JDDW 2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-07-25   Modified: 2021-02-19  

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