| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The muscle differentiation has been a model for developmental and regenerative research since the discovery of the world's first master factor, the transcription factor MyoD. Furthermore, we have reported that the repressive transcription factor Rp58 is a key component of the gene network for muscle differentiation and that DNA methylation is essential for muscle development and regeneration as epigenomic information. On the basis of these findings, the present study clarified the mechanism of cell fate determination involving DNA methylation of Rp58 in muscle differentiation.
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