Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapy

Research Project

Project/Area Number	18K19607
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	Kanazawa University
Principal Investigator	Daikoku Takiko 金沢大学, 学際科学実験センター, 教授 (30767249)
Co-Investigator(Kenkyū-buntansha)	藤原浩金沢大学, 医学系, 教授 (30252456) 中村充宏金沢大学, 医学系, 講師 (50377397)
Project Period (FY)	2018-06-29 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000) Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	子宮肉腫 / マウスモデル / 子宮がん / 子宮間質肉腫
Outline of Final Research Achievements	We previously established a novel uterine sarcoma mouse model by long-term treatment of progesterone to uterine specific Pten null mice. In this research, we found that normal Pten in uterine epithelium is essential to repress initiation of uterine stromal sarcoma in mouse. We also found some candidates which plays important role for initiation of uterine stromal sarcoma.
Academic Significance and Societal Importance of the Research Achievements	本研究で得られた子宮間質肉腫発生に上皮細胞の作用が影響するという結果は新しい知見であり、学術的意義がある。また、本研究で新たに発見された子宮間質肉腫発生に関わると考えられる因子は、子宮肉腫の新たな治療ターゲットとなり、新規治療薬の開発につながると考えられ、社会的意義がある。