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Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapy

Research Project

Project/Area Number 18K19607
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionKanazawa University

Principal Investigator

Daikoku Takiko  金沢大学, 学際科学実験センター, 教授 (30767249)

Co-Investigator(Kenkyū-buntansha) 藤原 浩  金沢大学, 医学系, 教授 (30252456)
中村 充宏  金沢大学, 医学系, 講師 (50377397)
Project Period (FY) 2018-06-29 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords子宮肉腫 / マウスモデル / 子宮がん / 子宮間質肉腫
Outline of Final Research Achievements

We previously established a novel uterine sarcoma mouse model by long-term treatment of progesterone to uterine specific Pten null mice. In this research, we found that normal Pten in uterine epithelium is essential to repress initiation of uterine stromal sarcoma in mouse. We also found some candidates which plays important role for initiation of uterine stromal sarcoma.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた子宮間質肉腫発生に上皮細胞の作用が影響するという結果は新しい知見であり、学術的意義がある。また、本研究で新たに発見された子宮間質肉腫発生に関わると考えられる因子は、子宮肉腫の新たな治療ターゲットとなり、新規治療薬の開発につながると考えられ、社会的意義がある。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (2 results)

All 2019 Other

All Int'l Joint Research (1 results) Presentation (1 results)

  • [Int'l Joint Research] Ohio State University/University of Cincinnati(米国)

    • Related Report
      2019 Annual Research Report
  • [Presentation] マウスモデルを用いた子宮がん発生を制御する分子機構の解明2019

    • Author(s)
      寺川純平、井之上幸範、松岡歩、水本泰成、藤原浩、大黒多希子
    • Organizer
      第55回北陸生殖医学会
    • Related Report
      2019 Annual Research Report

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Published: 2018-07-25   Modified: 2025-01-30  

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