Histopathological changes and their autoimmune mechanisms in chorioretinal diseases

• Project/Area Number: 18K19610
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
• Research Institution: Kyoto University
• Principal Investigator: Tsujikawa Akitaka 京都大学, 医学研究科, 教授 (40402846)
• Co-Investigator(Kenkyū-buntansha): 村岡 勇貴 京都大学, 医学研究科, 助教 (00739089) ; 大音 壮太郎 京都大学, 医学研究科, 特定講師 (10511850) ; 池田 華子 京都大学, 医学研究科, 准教授 (20372162) ; 村上 智昭 京都大学, 医学研究科, 講師 (50549095) ; 亀田 隆範 京都大学, 医学研究科, 助教 (60569961)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 糖尿病網膜症 / 加齢黄斑変性 / 光干渉断層計アンギオグラフィー / 抗VEGF療法 / 自己抗体 / ゲノムワイドイド関連解析 / 補体 / 網膜静脈閉塞症 / 抗fumarase抗体 / 抗hexokinase 1抗体 / 視細胞障害 / 糖尿病黄斑浮腫 / 光干渉断層計 / 自己免疫

Outline of Final Research Achievements

In the current study, the state-of-the-art fundus imaging technologies revealed that vascular damage and neuroglial degeneration promote each other in irremediable chorioretinal diseases. In particular, we demonstrated novel single nucleotide polymorphisms (SNPs) in genes of complement and proinflammatory factors using genome-wide association study (GWAS) in age-related macular degeneration and central serous chorioretinopathy. We identified novel autoantibodies, anti-fumarase antibody and anti-hexokinase 1 antibody in diabetic macular edema. Anti-fumarase antibody is associated with reduced visual acuity and photoreceptor damage. Translational researches elucidated that this autoantibody promotes the dropout of photoreceptor inner and outer segments. Some of these biomarkers predict functional structural efficacy of the standard treatment for chorioretinal diseases. These results promote our understanding of pathogenesis and suggest novel therapeutic targets in these diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究では、最新の眼底イメージング技術を用いた解析で網脈絡膜疾患の病態理解を深めた。また、臨床的には、眼底所見や液性免疫に関わるゲノム情報、血清中の自己抗体など、診断的価値や予後予測が示唆される新たなバイオマーカーを複数同定した。それらの中で、糖尿病網膜症や加齢黄斑変性等では、治療効果の予測因子も見出しており、今後のオーダーメイド医療の促進に役立つ可能性が示唆される。特に糖尿病黄斑浮腫においては、自己抗体が補体と協働して視細胞障害を惹起する分子機構が明らかとなり、新たな治療標的となる可能性がある。つまり、本研究では、網脈絡膜疾患の診断と治療の進歩に多大な貢献があったと考えられる。

Research Products

• [Journal Article] Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image (2020)
  • Author(s): Sawai Y, Miyata M, Uji A, Ooto S, Tamura H, Ueda-Arakawa N, Muraoka Y, Miyake M, Takahashi A, Kawashima Y, Kadomoto S, Oritani Y, Kawai K, Yamashiro K, Tsujikawa A.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 6172-6172
  • DOI: 10.1038/s41598-020-62607-6
  • NAID: 120006840169
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error (2020)
  • Author(s): Fan Qiao、Consortium for Refractive Error and Myopia
  • Journal Title: Communications Biology Volume: 3 Issue: 1 Pages: 133-133
  • DOI: 10.1038/s42003-020-0802-y
  • Peer Reviewed
• [Journal Article] Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model (2020)
  • Author(s): Hasegawa Tomoko、Ikeda Hanako Ohashi、Gotoh Norimoto、Iida Kei、Iwai Sachiko、Nakano Noriko、Kakizuka Akira、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 4251-4251
  • DOI: 10.1038/s41598-020-61160-6
  • NAID: 120006870291
  • Peer Reviewed / Open Access
• [Journal Article] Safety and Effectiveness of a Novel Neuroprotectant, KUS121, in Patients With Non-Arteritic Central Retinal Artery Occlusion: An Open-Label, Non-Randomized, First-In-Humans, Phase 1/2 Trial (2020)
  • Author(s): Ikeda HO, Muraoka Y, Hata M, Sumi E, Ikeda T, Nakagawa T, Abe H, Tada H, Morita S, Kakizuka A, Yoshimura N, Tsujikawa A
  • Journal Title: Plos ONE Volume: 15 Issue: 2 Pages: e0229068-e0229068
  • DOI: 10.1371/journal.pone.0229068
  • NAID: 120006799242
  • Peer Reviewed / Open Access
• [Journal Article] Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography (2020)
  • Author(s): Kogo Takahiro、Muraoka Yuki、Iida Yuto、Ooto Sotaro、Murakami Tomoaki、Kadomoto Shin、Iida-Miwa Yuko、Numa Shogo、Miyake Masahiro、Miyata Manabu、Uji Akihito、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 61 Issue: 2 Pages: 8-8
  • DOI: 10.1167/iovs.61.2.8
  • Peer Reviewed
• [Journal Article] Hyperreflective Foci in the Outer Retinal Layers as a Predictor of the Functional Efficacy of Ranibizumab for Diabetic Macular Edema (2020)
  • Author(s): Yoshitake Tatsuya、Murakami Tomoaki、Suzuma Kiyoshi、Dodo Yoko、Fujimoto Masahiro、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 873-873
  • DOI: 10.1038/s41598-020-57646-y
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Biomarkers in the VEGF Pathway Predicting Response to anti-VEGF Therapy in Age-Related Macular Degeneration (2019)
  • Author(s): Balikova I, Postelmans L, Pasteels B, Coquelet P, Catherine J, Efendic A, Hosoda Y, Miyake M, Yamashiro K; ANGEL study group members, Thienpont B, Lambrechts D.
  • Journal Title: BMJ Open Ophthalmol Volume: 4 Issue: 1 Pages: e000273-e000273
  • DOI: 10.1136/bmjophth-2019-000273
  • Peer Reviewed
• [Journal Article] Wide-field fundus autofluorescence imaging in patients with hereditary retinal degeneration: a literature review (2019)
  • Author(s): Oishi Akio、Miyata Manabu、Numa Shogo、Otsuka Yuki、Oishi Maho、Tsujikawa Akitaka
  • Journal Title: International Journal of Retina and Vitreous Volume: 5 Issue: S1 Pages: 23-23
  • DOI: 10.1186/s40942-019-0173-z
  • Peer Reviewed
• [Journal Article] Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy (2019)
  • Author(s): Hosoda Yoshikatsu、Miyake Masahiro、Schellevis Rosa L.、Boon Camiel J. F.、Hoyng Carel B.、Miki Akiko、Meguro Akira、Sakurada Yoichi、Yoneyama Seigo、Takasago Yukari、Hata Masayuki、Muraoka Yuki、Nakanishi Hideo、Oishi Akio、Ooto Sotaro、Tamura Hiroshi、Uji Akihito、Miyata Manabu、et. al.
  • Journal Title: Communications Biology Volume: 2 Issue: 1 Pages: 468-468
  • DOI: 10.1038/s42003-019-0712-z
  • NAID: 120006773934
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Photodynamic Therapy for Polypoidal Choroidal Vasculopathy Associated with and without Pachychoroid Phenotypes (2019)
  • Author(s): Hata Masayuki、Tagawa Miho、Oishi Akio、Kawashima Yu、Nakata Isao、Akagi-Kurashige Yumiko、Yamashiro Kenji、Ooto Sotaro、Tamura Hiroshi、Miyata Manabu、Miyake Masahiro、Ueda-Arakawa Naoko、Takahashi Ayako、Tsujikawa Akitaka
  • Journal Title: Ophthalmology Retina Volume: 3 Issue: 12 Pages: 1016-1025
  • DOI: 10.1016/j.oret.2019.06.013
  • Peer Reviewed
• [Journal Article] Current practice in the management of branch retinal vein occlusion in Japan: Survey results of retina specialists in Japan. (2019)
  • Author(s): Ogura Y, Kondo M, Kadonosono K, Shimura M, Kamei M, Tsujikawa A
  • Journal Title: Jpn J Ophthalmol Volume: 63 Issue: 5 Pages: 365-373
  • DOI: 10.1007/s10384-019-00685-4
  • Peer Reviewed
• [Journal Article] Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium (2019)
  • Author(s): Wong Yee-Ling、et al.
  • Journal Title: PLOS ONE Volume: 14 Issue: 8 Pages: 0220143-0220143
  • DOI: 10.1371/journal.pone.0220143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optical Coherence Tomography-Based Deep-Learning Models for Classifying Normal and Age-Related Macular Degeneration and Exudative and Non-Exudative Age-Related Macular Degeneration Changes (2019)
  • Author(s): N. Motozawa, G. An, S. Takagi, S. Kitahata, M. Mandai, Y. Hirami, H. Yokota, M. Akiba, A. Tsujikawa, M. Takahashi, and Y. Kurimoto
  • Journal Title: Ophthalmology and Therapy Volume: Vol. 8 Issue: 4 Pages: 527-539
  • DOI: 10.1007/s40123-019-00207-y
  • Peer Reviewed / Open Access
• [Journal Article] Arteriovenous Crossing Associated With Branch Retinal Vein Occlusion (2019)
  • Author(s): Muraoka Y, Tsujikawa A.
  • Journal Title: Jpn J Ophthalmol Volume: 63 Issue: 5 Pages: 353-364
  • DOI: 10.1007/s10384-019-00676-5
  • Peer Reviewed
• [Journal Article] Predictive Genes for the Prognosis of Central Serous Chorioretinopathy (2019)
  • Author(s): Hosoda Yoshikatsu、Yamashiro Kenji、Miyake Masahiro、Ooto Sotaro、Oishi Akio、Miyata Manabu、Uji Akihito、Khor Chiea Chuen、Wong Tien Yin、Tsujikawa Akitaka
  • Journal Title: Ophthalmology Retina Volume: 3 Issue: 11 Pages: 985-992
  • DOI: 10.1016/j.oret.2019.05.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ranibizumab treatment improves diabetic macular oedema without influencing retinal oximetry parameters (2019)
  • Author(s): Takasago Yukari、Fujita Tomoyoshi、Nakano Yuki、Osaka Rie、Miyake Masahiro、Muraoka Yuki、Tsujikawa Akitaka
  • Journal Title: Acta Ophthalmologica Volume: 97 Issue: 8 Pages: 1048-1053
  • DOI: 10.1111/aos.14145
  • Peer Reviewed
• [Journal Article] Predictor of Early Remission of Diabetic Macular Edema under As-Needed Intravitreal Ranibizumab (2019)
  • Author(s): Yoshitake Tatsuya、Murakami Tomoaki、Suzuma Kiyoshi、Fujimoto Masahiro、Dodo Yoko、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 7599-7599
  • DOI: 10.1038/s41598-019-44078-6
  • Peer Reviewed / Open Access
• [Journal Article] Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma (2019)
  • Author(s): Akagi T, Uji A, Okamoto Y, Suda K, Kameda T, Nakanishi H, Ikeda HO, Miyake M, Nakano E, Motozawa N, Tsujikawa A
  • Journal Title: Am J Ophthalmol Volume: 208 Pages: 313-322
  • DOI: 10.1016/j.ajo.2019.05.008
  • Peer Reviewed
• [Journal Article] Branch Retinal Vein Occlusion: Treatment Outcomes According to the Retinal Nonperfusion Area, Clinical Subtype, and Crossing Pattern (2019)
  • Author(s): Iida-Miwa Yuko、Muraoka Yuki、Iida Yuto、Ooto Sotaro、Murakami Tomoaki、Suzuma Kiyoshi、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 6569-6569
  • DOI: 10.1038/s41598-019-42982-5
  • NAID: 120006629253
  • Peer Reviewed / Open Access
• [Journal Article] Limited efficacy of adalimumab in the acute phase of serpiginous choroiditis refractory to corticosteroid and cyclosporine, a case report (2019)
  • Author(s): Noda Kazunori、Oishi Akio、Uji Akihito、Tanaka Saori、Tsujikawa Akitaka
  • Journal Title: BMC Ophthalmology Volume: 19 Issue: 1 Pages: 95-95
  • DOI: 10.1186/s12886-019-1104-3
  • NAID: 120006629158
  • Peer Reviewed
• [Journal Article] Characteristics of Diabetic Capillary Nonperfusion in Macular and Extramacular White Spots on Optical Coherence Tomography Angiography (2019)
  • Author(s): Morino Kazuya、Murakami Tomoaki、Dodo Yoko、Yasukura Shota、Yoshitake Tatsuya、Fujimoto Masahiro、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 60 Issue: 5 Pages: 1595-1595
  • DOI: 10.1167/iovs.18-26534
  • Peer Reviewed
• [Journal Article] A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field. (2019)
  • Author(s): Kadomoto S, Uji A, Muraoka Y, Akagi T, Miyata M, Tsujikawa A.
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: in press Issue: 6 Pages: 1199-1206
  • DOI: 10.1007/s00417-019-04310-5
  • Peer Reviewed
• [Journal Article] Concentric Choriocapillaris Flow Deficits in Retinitis Pigmentosa Detected Using Wide-Angle Swept-Source Optical Coherence Tomography Angiography. (2019)
  • Author(s): Miyata M, Oishi A, Hasegawa T, Oishi M, Numa S, Otsuka Y, Uji A, Kadomoto S, Hata M, Ikeda HO, Tsujikawa A.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 60 Issue: 4 Pages: 1044-1049
  • DOI: 10.1167/iovs.18-26176
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Hexokinase 1 Antibody as a Novel Serum Biomarker of a Subgroup of Diabetic Macular Edema. (2019)
  • Author(s): Yoshitake Tatsuya、Murakami Tomaoki、Yoshitake Shin、Suzuma Kiyoshi、Dodo Yoko、Fujimoto Masahiro、Ito Shinji、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 787-794
  • DOI: 10.1038/s41598-019-39777-z
  • NAID: 120006596560
  • Peer Reviewed / Open Access
• [Journal Article] Four-Year Outcome of Aflibercept for Neovascular Age-Related Macular Degeneration and polypoidal choroidal vasculopathy (2019)
  • Author(s): Nishikawa Keiichi、Oishi Akio、Hata Masayuki、Miyake Masahiro、Ooto Sotaro、Yamashiro Kenji、Miyata Manabu、Tamura Hiroshi、Ueda-Arakawa Naoko、Takahashi Ayako、Kawashima Yu、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 30842468-30842468
  • DOI: 10.1038/s41598-019-39995-5
  • NAID: 120006591360
  • Peer Reviewed / Open Access
• [Journal Article] Retinal oximetry in branch retinal vein occlusion (2019)
  • Author(s): Osaka Rie、Nakano Yuki、Takasago Yukari、Fujita Tomoyoshi、Yamashita Ayana、Shiragami Chieko、Muraoka Yuki、Tsujikawa Akitaka
  • Journal Title: Acta Ophthalmologica Volume: 97 Issue: 6 Pages: 896-901
  • DOI: 10.1111/aos.14070
  • Peer Reviewed
• [Journal Article] Anti-Fumarase Antibody as a Predictor of Functional Efficacy of Anti-VEGF Therapy for Diabetic Macular Edema (2019)
  • Author(s): Yoshitake Tatsuya、Murakami Tomaoki、Yoshitake Shin、Suzuma Kiyoshi、Dodo Yoko、Fujimoto Masahiro、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 60 Issue: 2 Pages: 787-787
  • DOI: 10.1167/iovs.18-26209
  • Peer Reviewed
• [Journal Article] One-Year Outcome Predictors of Strabismus Surgery from Anterior Segment Optical Coherence Tomography with Multiple B-Scan Averaging (2019)
  • Author(s): Miyata Manabu、Suda Kenji、Uji Akihito、Hata Masayuki、Oishi Akio、Nakano Eri、Yamamoto Akinari、Nakao Shinya、Ohtsuki Hiroshi、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2523-2523
  • DOI: 10.1038/s41598-019-39361-5
  • NAID: 120006559398
  • Peer Reviewed / Open Access
• [Journal Article] Multiple Subretinal Fluid Blebs After Pars Plana Vitrectomy for Rhegmatogenous Retinal Detachment Repair (2019)
  • Author(s): Otsuka Y, Oishi A, Suda K, Tsujikawa A, Kurakazu T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 257 Issue: 5 Pages: 921-929
  • DOI: 10.1007/s00417-018-04231-9
  • Peer Reviewed
• [Journal Article] FIXATION STATUS AFTER RESOLUTION OF MACULAR EDEMA ASSOCIATED WITH BRANCH RETINAL VEIN OCCLUSION (2019)
  • Author(s): Kogo Takahiro、Muraoka Yuki、Ooto Sotaro、Suzuma Kiyoshi、Murakami Tomoaki、Iida Yuto、Iida-Miwa Yuko、Ghashut Rima、Miyata Manabu、Tsujikawa Akitaka
  • Journal Title: Retina Volume: 39 Issue: 10 Pages: 1896-1905
  • DOI: 10.1097/iae.0000000000002250
  • Peer Reviewed
• [Journal Article] MACULAR ATROPHY FINDINGS BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY COMPARED WITH FUNDUS AUTOFLUORESCENCE IN TREATED EXUDATIVE AGE-RELATED MACULAR DEGENERATION (2019)
  • Author(s): Takasago Yukari、Shiragami Chieko、Kobayashi Mamoru、Osaka Rie、Ono Aoi、Yamashita Ayana、Tsujikawa Akitaka、Hirooka Kazuyuki
  • Journal Title: Retina Volume: 39 Issue: 2 Pages: 296-302
  • DOI: 10.1097/iae.0000000000001980
  • Peer Reviewed
• [Journal Article] Anti-fumarase antibody promotes the dropout of photoreceptor inner and outer segments in diabetic macular oedema (2018)
  • Author(s): Yoshitake Shin、Murakami Tomoaki、Suzuma Kiyoshi、Yoshitake Tatsuya、Uji Akihito、Morooka Satoshi、Dodo Yoko、Fujimoto Masahiro、Shan Yang、Fort Patrice E.、Ito Shinji、Tsujikawa Akitaka、Yoshimura Nagahisa
  • Journal Title: Diabetologia Volume: 62 Issue: 3 Pages: 504-516
  • DOI: 10.1007/s00125-018-4773-1
  • Peer Reviewed
• [Journal Article] Granular lesions of short-wavelength and near-infrared autofluorescence in diabetic macular oedema (2018)
  • Author(s): Yoshitake Shin、Murakami Tomoaki、Uji Akihito、Fujimoto Masahiro、Dodo Yoko、Suzuma Kiyoshi、Tsujikawa Akitaka
  • Journal Title: Eye Volume: 33 Issue: 4 Pages: 564-571
  • DOI: 10.1038/s41433-018-0256-3
  • Peer Reviewed
• [Journal Article] Novel Predictors of Visual Outcome in Anti-VEGF Therapy for Myopic Choroidal Neovascularization Derived Using OCT Angiography (2018)
  • Author(s): Hosoda Yoshikatsu、Miyata Manabu、Uji Akihito、Ooto Sotaro、Yamashiro Kenji、Tamura Hiroshi、Oishi Akio、Ueda-Arakawa Naoko、Miyake Masahiro、Hata Masayuki、Muraoka Yuki、Takahashi Ayako、Tsujikawa Akitaka
  • Journal Title: Ophthalmology Retina Volume: 2 Issue: 11 Pages: 1118-1124
  • DOI: 10.1016/j.oret.2018.04.011
  • Peer Reviewed
• [Journal Article] Multimodal Imaging for Differential Diagnosis of Bietti Crystalline Dystrophy (2018)
  • Author(s): Oishi A, Oishi M, Miyata M, Hirashima T, Hasegawa T, Numa S, Tsujikawa A
  • Journal Title: Ophthalmology Retina Volume: 印刷中 Issue: 10 Pages: 1071-1077
  • DOI: 10.1016/j.oret.2018.02.012
  • Peer Reviewed
• [Journal Article] Pachychoroid Geographic Atrophy: Clinical and Genetic Characteristics (2018)
  • Author(s): 10.Takahashi A, Ooto S, Yamashiro K, Tamura H, Oishi, A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A.
  • Journal Title: Ophthalmology Retina Volume: in press Issue: 4 Pages: 295-305
  • DOI: 10.1016/j.oret.2017.08.016
  • Peer Reviewed
• [Journal Article] Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography (2018)
  • Author(s): Yasukura Shota、Murakami Tomoaki、Suzuma Kiyoshi、Yoshitake Tatsuya、Nakanishi Hideo、Fujimoto Masahiro、Oishi Maho、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 15 Pages: 5893-5893
  • DOI: 10.1167/iovs.18-25108
  • Peer Reviewed
• [Journal Article] Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit (2018)
  • Author(s): Muraoka Yuki、Uji Akihito、Ishikura Masaharu、Iida Yuto、Ooto Sotaro、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 15 Pages: 5847-5847
  • DOI: 10.1167/iovs.18-25301
  • Peer Reviewed
• [Journal Article] Time-Course Change in Eye Shape and Development of Staphyloma in Highly Myopic Eyes (2018)
  • Author(s): Wakazono Tomotaka、Yamashiro Kenji、Miyake Masahiro、Hata Masayuki、Miyata Manabu、Uji Akihito、Nakanishi Hideo、Oishi Akio、Tamura Hiroshi、Ooto Sotaro、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 13 Pages: 5455-5455
  • DOI: 10.1167/iovs.18-24754
  • Peer Reviewed / Open Access
• [Journal Article] Persistent metamorphopsia associated with branch retinal vein occlusion (2018)
  • Author(s): Osaka Rie、Manabe Koichiro、Manabe Saki、Nakano Yuki、Takasago Yukari、Shiragami Chieko、Hirooka Kazuyuki、Muraoka Yuki、Tsujikawa Akitaka
  • Journal Title: PLOS ONE Volume: 13 Issue: 9 Pages: e0204015-e0204015
  • DOI: 10.1371/journal.pone.0204015
  • Peer Reviewed / Open Access
• [Journal Article] One-year outcomes of fixed treatment of intravitreal aflibercept for exudative age-related macular degeneration and the factor of visual prognosis (2018)
  • Author(s): Ono Aoi、Shiragami Chieko、Manabe Saki、Takasago Yukari、Osaka Rie、Kobayashi Mamoru、Yamashita Ayana、Tsujikawa Akitaka、Hirooka Kazuyuki
  • Journal Title: Medicine Volume: 97 Issue: 31 Pages: e11737-e11737
  • DOI: 10.1097/md.0000000000011737
  • Peer Reviewed
• [Journal Article] Outer Plexiform Layer Elevations as a Marker for Prior Ocular Attacks in Patients With Behcet's Disease (2018)
  • Author(s): Kido Ai、Uji Akihito、Morooka Satoshi、Kuroda Yoshimasa、Arichika Shigeta、Akagi Tadamichi、Tsujikawa Akitaka
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 7 Pages: 2828-2828
  • DOI: 10.1167/iovs.18-24348
  • Peer Reviewed
• [Journal Article] Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography (2018)
  • Author(s): Murakami Tomoaki、Suzuma Kiyoshi、Dodo Yoko、Yoshitake Tatsuya、Yasukura Shota、Nakanishi Hideo、Fujimoto Masahiro、Oishi Maho、Tsujikawa Akitaka
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 8798-8798
  • DOI: 10.1038/s41598-018-27192-9
  • NAID: 120006502592
  • Peer Reviewed / Open Access
• [Journal Article] Five-year visual outcomes after anti-VEGF therapy with or without photodynamic therapy for polypoidal choroidal vasculopathy (2018)
  • Author(s): Miyata Manabu、Ooto Sotaro、Yamashiro Kenji、Tamura Hiroshi、Hata Masayuki、Ueda-Arakawa Naoko、Yoshikawa Munemitsu、Numa Shogo、Tsujikawa Akitaka
  • Journal Title: British Journal of Ophthalmology Volume: 103 Issue: 5 Pages: 617-622
  • DOI: 10.1136/bjophthalmol-2018-311963
  • NAID: 120006547389
  • Peer Reviewed
• [Journal Article] CFHandVIPR2as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy (2018)
  • Author(s): Hosoda Yoshikatsu、Tsujikawa Akitaka、Nagahama Study Group
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 24 Pages: 6261-6266
  • DOI: 10.1073/pnas.1802212115
  • NAID: 120006473758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error (2018)
  • Author(s): Tedja Milly S.、23andMe Research Team、UK Biobank Eye and Vision Consortium
  • Journal Title: Nature Genetics Volume: 50 Issue: 6 Pages: 834-848
  • DOI: 10.1038/s41588-018-0127-7
  • Peer Reviewed
• [Journal Article] CCDC102B confers risk of low vision and blindness in high myopia (2018)
  • Author(s): Hosoda Yoshikatsu、Nagahama Study group、Yoshikawa Munemitsu、Miyake Masahiro、Tabara Yasuharu、Shimada Noriaki、Zhao Wanting、Oishi Akio、Nakanishi Hideo、Hata Masayuki、Akagi Tadamichi、Ooto Sotaro、Nagaoka Natsuko、Fang Yuxin、Ohno-Matsui Kyoko、Cheng Ching-Yu、Saw Seang Mei、Yamada Ryo、Matsuda Fumihiko、
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1782-1782
  • DOI: 10.1038/s41467-018-03649-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reduction of lipid accumulation rescues Bietti’s crystalline dystrophy phenotypes (2018)
  • Author(s): Hata Masayuki、Ikeda Hanako O.、Iwai Sachiko、Iida Yuto、Gotoh Norimoto、Asaka Isao、Ikeda Kazutaka、Isobe Yosuke、Hori Aya、Nakagawa Saori、Yamato Susumu、Arita Makoto、Yoshimura Nagahisa、Tsujikawa Akitaka
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Issue: 15 Pages: 3936-3941
  • DOI: 10.1073/pnas.1717338115
  • NAID: 120006416205
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of posterior staphyloma and factors associated with its shape in the Japanese population. (2018)
  • Author(s): Numa S. Yamashiro K. Wakazono T. Yoshikawa M. Miyake M. Nakanishi H. Oishi A. Nagahama Study Group. Tabara Y. Matsuda F. Yoshimura N. Tsujikawa A.
  • Journal Title: Sci Rep. Volume: 15 Issue: 1 Pages: 4594-4594
  • DOI: 10.1038/s41598-018-22759-y
  • NAID: 120006502587
  • Peer Reviewed / Open Access
• [Journal Article] MACULAR ATROPHY AND MACULAR MORPHOLOGY IN AFLIBERCEPT-TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. (2018)
  • Author(s): Kuroda Y, Yamashiro K, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyata M, Hata M, Takahashi A, Wakazono T, Yoshimura N, Tsujikawa A
  • Journal Title: Retina Volume: 印刷中 Issue: 9 Pages: 1743-1750
  • DOI: 10.1097/iae.0000000000001765
  • Peer Reviewed
• [Journal Article] ASSOCIATION BETWEEN PARAFOVEAL CAPILLARY NONPERFUSION AND MACULAR FUNCTION IN EYES WITH BRANCH RETINAL VEIN OCCLUSION. (2017)
  • Author(s): Manabe S, Osaka R, Nakano Y, Takasago Y, Fujita T, Shiragami C, Hirooka K, Muraoka Y, Tsujikawa A.
  • Journal Title: Retina. Volume: 37 Issue: 8 Pages: 1731-1737
  • DOI: 10.1097/iae.0000000000001749
  • Peer Reviewed
• [Presentation] Choroidal neovascularization classification system based on machine learning to distinguish pachychoroid neovasculopathy from age-related macular degeneration. (2019)
  • Author(s): Masahiro Miyake; Yoshikatsu Hosoda; Kenji Yamashiro; Sotaro Ooto; Ayako Takahashi; Akio Oishi; Manabu Miyata; Akihito Uji; Hiroshi Tamura; Masayuki Hata; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Investigation on light-induced retinal damage in retinitis pigmentosa (2019)
  • Author(s): Yuki Otsuka; Akio Oishi; Manabu Miyata; Akihito Uji; maho oishi; tomoko hasegawa; Shogo Numa; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Clinical and Genetic Characteristic of Pachydrusen in Eyes with Central Serous Chorioretinopathy and Normal Subjects (2019)
  • Author(s): Ayako Takahashi; Yoshikatsu Hosoda; Masahiro Miyake; Akio Oishi; Sotaro Ooto; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Significant Correlation between Ganglion Cell Layer & Inner Plexiform Layer Thickness and Retinal Sensitivity Changes After Intravitreal Aflibercept Treatment in Eyes with Exudative Age-related Macular Degeneration (2019)
  • Author(s): Rie Osaka; Chieko Shiragami; Aoi Ono; Yukari Takasago; Mamoru Kobayashi; Ayana Yamashita; Saki Manabe; Akitaka Tsujikawa; Kiyoshi Suzuma
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Detailed characteristics of EYS variants in Japanese patients with retinitis pigmentosa (2019)
  • Author(s): Shogo Numa; Akio Oishi; maho oishi; tomoko hasegawa; Kenji Ishihara; Manabu Miyata; Yuki Otsuka; Takako Hirashima; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] In vivo imaging of retinal ganglion cells in the human eye with adaptive optics optic coherence tomography (2019)
  • Author(s): Shin Kadomoto; Akihito Uji; Yuki Muraoka; Ryosuke Tamiya; Koji Nozato; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Comparison of toric IOL stability after combined 25-gauge vitrectomy surgery for ERM (2019)
  • Author(s): Yuki Nakano; Tomoyoshi Fujita; Aoi Ono; Mamoru Kobayashi; Rie Osaka; Yukari Takasago; Chieko Shiragami; Akitaka Tsujikawa; Suzuma Kiyoshi
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Vessel Position of the Arteriovenous Crossing in Branch Retinal Vein Occlusion (2019)
  • Author(s): Takahiro Kogo; Yuki Muraoka; Yuto Iida; Sotaro Ooto; Tomoaki Murakami; Yuko Iida-Miwa; Shin Kadomoto; Akihito Uji; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma (2019)
  • Author(s): Tadamichi Akagi; Akihito Uji; Yoko Okamoto; Kenji Suda; Takanori Kameda; Hideo Nakanishi; Hanako Ohashi Ikeda; Masahiro Miyake; Eri Nakano; Naohiro Motozawa; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Enhanced Visualization of the Inner Retinal Layers Using Adaptive Optics Optical Coherence Tomography (2019)
  • Author(s): Ryosuke Tamiya; Yuki Muraoka; Shin Kadomoto; Akihito Uji; Koji Nozato; Akitaka Tsujikawa
  • Organizer: ARVO Imaging in the Eye Conference 2019
• [Presentation] Choriocapillaris imaging in patients with Behcet′s disease using optical coherence tomography angiography and image averaging (2019)
  • Author(s): Yu Kawashima; Akihito Uji; Manabu Miyata; Satoshi Morooka; Yuki Muraoka; Tadamichi Akagi; Akitaka Tsujikawa
  • Organizer: ARVO Imaging in the Eye Conference 2019
• [Presentation] Clinical characteristics of eyes with steroid-induced glaucoma requiring surgery (2019)
  • Author(s): Asako Okamura; Kenji Suda; Tadamichi Akagi; Takanori Kameda; Hanako Ohashi Ikeda; Masahiro Miyake; tomoko hasegawa; Eri Nakano; Yoko Okamoto; Naohiro Motozawa; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Automated cell culture for the differentiation of induced pluripotent stem cells into retinal pigment epithelial cells by LabDroid (2019)
  • Author(s): Naohiro Motozawa; Akitaka Tsujikawa; Masayo Takahashi
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Characteristics of Diabetic Capillary Nonperfusion in Extramacular White Spots on Optical Coherence Tomography Angiography (2019)
  • Author(s): Kazuya Morino; Tomoaki Murakami; Tatsuya Yoshitake; Yoko Dodo; Masahiro Fujimoto; shota yasukura; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Three-dimensional nonperfused area in temporal raphe of diabetic retinopathy on wide-field optical coherence tomography angiography (2019)
  • Author(s): Daiki Uchitomi; Tomoaki Murakami; Yoko Dodo; Kazuya Morino; shota yasukura; Tatsuya Yoshitake; Masahiro Fujimoto; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Clinical Characteristics of Eyes with Steroid Use in a Japanese Glaucoma Clinic (2019)
  • Author(s): Kenji Suda; Tadamichi Akagi; Ikeda Ohashi Hanako; Takanori Kameda; tomoko hasegawa; Hideo Nakanishi; Satoshi Morooka; Akitaka Tsujikawa
  • Organizer: ARVO Annual Meeting 2019
• [Presentation] Structure analysis of the choriocapillaris in normal eyes by multiple en face optical coherence tomography angiography image averaging (2018)
  • Author(s): Ai Fukunishi; Sotaro Ooto; Akihito Uji; Takuro Kamei; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Choriocapillaris structure in the fellow eye of neovascular age-related macular degeneration patients: an OCT angiography image averaging study (2018)
  • Author(s): Takuro Kamei; Sotaro Ooto; Akihito Uji; Ai Fukunishi; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Four-Layered Retinal Vasculature and Retinal Circulatory Unit Differentiated using High-Resolution Optical Coherence Tomography Angiography (2018)
  • Author(s): Yuki Muraoka; Akihito Uji; Masaharu Ishikura; Sotaro Ooto; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Association between hyperreflective foci in the outer retinal layers and functional efficacy of ranibizumab for diabetic macular edema (2018)
  • Author(s): Tomoaki Murakami; Kiyoshi Suzuma; Tatsuya Yoshitake; Hideo Nakanishi; Masahiro Fujimoto; Maho Oishi; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Association Between Aqueous VEGF Levels and Clinical Parameters in Ranibizumab Treatment for Eyes with Branch Retinal Vein Occlusion (2018)
  • Author(s): Masahiro Miyake; Yuki Muraoka; Ayako Takahashi; Yuko Iida-Miwa; Tomoaki Murakami; Sotaro Ooto; Rima Ghashut; Kiyoshi Suzuma; Akitaka Tsujikawa; Yuto Iida
  • Organizer: ARVO annual meeting
• [Presentation] Effect of Retinal Nonperfusion on Two-Year Outcomes of Ranibizumab Treatment for Eyes with Branch Retinal Vein Occlusion (2018)
  • Author(s): Akitaka Tsujikawa; Yuki Muraoka; Sotaro Ooto; Yuto Iida; Kiyoshi Suzuma; Tomoaki Murakami; Masahiro Miyake; Rima Ghashut; Yuko Iida-Miwa
  • Organizer: ARVO annual meeting
• [Presentation] Visualization of Four-layered Retinal Vasculature: High-Resolution Optical Coherence Tomography Angiography Versus Non-Confocal Adaptive Optics Scanning Light Ophthalmoscopy (2018)
  • Author(s): Masaharu Ishikura; Akihito Uji; Yuki Muraoka; Sotaro Ooto; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Diabetic Capillary Nonperfusion in the Macula and Extramacular areas on Optical Coherence Tomography Angiography (2018)
  • Author(s): shota yasukura; Tomoaki Murakami; Kiyoshi Suzuma; Tatsuya Yoshitake; Masahiro Fujimoto; Hideo Nakanishi; Maho Oishi; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting
• [Presentation] Identification of anti-citrin antibody as a serum biomarker of diabetic retinopathy (2018)
  • Author(s): Tatsuya Yoshitake; Tomoaki Murakami; Kiyoshi Suzuma; Hideo Nakanishi; Masahiro Fujimoto; Yoko Dodo; Maho Oishi; Akitaka Tsujikawa
  • Organizer: ARVO annual meeting