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Do Bacteria Cause Cancer? Elucidation of "cell-microbiome interaction" using metabolism as an indicator

Research Project

Project/Area Number 18K19629
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 57:Oral science and related fields
Research InstitutionTohoku University

Principal Investigator

Takahashi Nobuhiro  東北大学, 歯学研究科, 教授 (60183852)

Co-Investigator(Kenkyū-buntansha) 鷲尾 純平  東北大学, 歯学研究科, 講師 (20400260)
Project Period (FY) 2018-06-29 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords細胞代謝 / 代謝阻害 / Porphyromonas gingivalis / Gingipain / ジンジバリス菌 / ジンジパイン / ベイヨネラ菌 / 有機酸 / がん細胞 / リアルタイム代謝測定 / pHスタット / 酸素分圧可変チャンバー / 口腔がん / がん化 / 代謝 / レンサ球菌 / フゾバクテリウム
Outline of Final Research Achievements

It is becoming clear that bacteria are involved in the canceration of cells. Therefore, in this study, we examined the effect of bacteria on cells using metabolism as an indicator using "real-time metabolism monitoring system" that we developed. As a result, the following were clarified. It was found that (1) Porphromonas gingivalis (Pg), which is the most representative periodontal disease-associated bacterium among oral bacteria, suppresses cellular glucose metabolism, (2) the cell glucose metabolism inhibitor is present in the culture supernatant of Pg, and (3) it is not a Pg-specific proteolytic enzyme gingipain but a completely different protein.

Academic Significance and Societal Importance of the Research Achievements

細菌が細胞のがん化に関わることが明らかになりつつある中、とくに口腔上皮は口腔細菌に常に触れており、その影響は不可避である。生命史の大部分において細胞と細菌は共存してきたが、研究は別々に進められてきた。細胞と細菌のインタラクションの新たな生物学が黎明期を迎える今、両者が共存する口腔を対象とする研究はその最前線となる。本研究で見出された細胞糖代謝をダイレクトに阻害するタンパク質の存在は、細胞と細菌のダイレクトなインタラクションの実例となるとともに、細菌による(がん)細胞コントロールの概念に新たな視点をもたらすものと考えられる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (72 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (20 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Open Access: 19 results) Presentation (42 results) (of which Int'l Joint Research: 20 results,  Invited: 21 results) Book (3 results)

  • [Int'l Joint Research] 四川大学/福建医科大学(中国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] FISABIO Foundation/University of Alicante(スペイン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Academic Centre for Dentistry Amsterdam/Maastricht University Medical Center(オランダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Leeds(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Airlangga University(インドネシア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] West China School of Stomatology(中国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Asrhus University(デンマーク)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Effectiveness of an actuator-driven pulsed water jet for removal of softened carious dentin2022

    • Author(s)
      YOKOYAMA-SATO Yuka、NISHIOKA Takashi、NAGANUMA Yukihiro、TAKAHASHI Masatoshi、NAKAGAWA Atsuhiro、YODA Nobuhiro、SASAKI Keiichi、TAKAHASHI Nobuhiro、TOMINAGA Teiji、IIKUBO Masahiro
    • Journal Title

      Dental Materials Journal

      Volume: 41 Issue: 4 Pages: 527-533

    • DOI

      10.4012/dmj.2021-234

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2022-07-25
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A water-soluble glass-based temporary restorative resin inhibited bacteria-induced pH reductions at the bacteria-material interface2022

    • Author(s)
      MAYANAGI Gen、YUFANG Luo、HOSHINO Tomohiro、TAKAHASHI Nobuhiro
    • Journal Title

      Dental Materials Journal

      Volume: 41 Issue: 1 Pages: 95-100

    • DOI

      10.4012/dmj.2021-129

    • NAID

      130008150327

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2022-01-25
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Importance of Nitrate Reduction for Oral Health2022

    • Author(s)
      Rosier B.T.、Takahashi N.、Zaura E.、Krom B.P.、Martinez-Espinosa R.M.、van Breda S.G.J.、Marsh P.D.、Mira A.
    • Journal Title

      Journal of Dental Research

      Volume: - Issue: 8 Pages: 002203452210809-002203452210809

    • DOI

      10.1177/00220345221080982

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions2022

    • Author(s)
      Liu Shan、Washio Jumpei、Sato Satoko、Abiko Yuki、Shinohara Yuta、Kobayashi Yuri、Otani Haruki、Sasaki Shiori、Wang Xiaoyi、Takahashi Nobuhiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 2 Pages: 989-989

    • DOI

      10.3390/ijms23020989

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Profiling system of oral microbiota utilizing polymerase chain reaction-restriction fragment length polymorphism analysis2021

    • Author(s)
      Sano H, Wakui A, Kawachi M, Washio J, Abiko Y, Mayanagi G, Yamaki K, Tanaka K, Takahashi N, Sato T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 63 Issue: 3 Pages: 292-297

    • DOI

      10.1016/j.job.2021.05.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness and safety of a new dental plaque removal device utilizing micro mist spray for removing oral biofilm in vitro2021

    • Author(s)
      Hihara Hiroki、Tagaino Ryo、Washio Jumpei、Laosuwan Kittipong、Wicaksono Dimas Prasetianto、Izumita Kuniyuki、Koide Rie、Takahashi Nobuhiro、Sasaki Keiichi
    • Journal Title

      BMC Oral Health

      Volume: 21 Issue: 1 Pages: 286-286

    • DOI

      10.1186/s12903-021-01647-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bacterial amounts and compositions in liquid baby formula and a baby drink consumed with an artificial nipple.2021

    • Author(s)
      Wakui A, Sano H, Kawachi M, Aida A, Takenaka Y, Yonezawa A, Nakahata N, Moriyama S, Nishikata M, Washio J, Abiko Y, Mayanagi G, Yamaki K, Sakashita R, Tanaka K, Takahashi N, Sato T
    • Journal Title

      J Oral Biosci.

      Volume: 印刷中 Issue: 2 Pages: 161-168

    • DOI

      10.1016/j.job.2021.03.001

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiling of microbiota at the mouth of bottles and in remaining tea after drinking directly from plastic bottles of tea2021

    • Author(s)
      Wakui A*, Sano H*, Hirabuki Y*, Kawachi M, Aida A, Washio J, Abiko Y, Mayanagi G, Yamaki K, Tanaka K, Takahashi N, Sato T
    • Journal Title

      Dentistry Journal

      Volume: 9 Issue: 6 Pages: 58-58

    • DOI

      10.3390/dj9060058

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxically cultured cells of oral squamous cell carcinoma increased their glucose metabolic activity under normoxic conditions2021

    • Author(s)
      Shinohara Yuta、Washio Jumpei、Kobayashi Yuri、Abiko Yuki、Sasaki Keiichi、Takahashi Nobuhiro
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 10 Pages: e0254966-e0254966

    • DOI

      10.1371/journal.pone.0254966

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bifacial biological effects of ethanol: acetaldehyde production by oral Streptococcus species and the antibacterial effects of ethanol against these bacteria2021

    • Author(s)
      Tagaino Ryo、Washio Jumpei、Otani Haruki、Sasaki Keiichi、Takahashi Nobuhiro
    • Journal Title

      Journal of Oral Microbiology

      Volume: 13 Issue: 1 Pages: 1937884-1937884

    • DOI

      10.1080/20002297.2021.1937884

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitrite Production from Nitrate and Its Link with Lactate Metabolism in Oral Veillonella spp.2020

    • Author(s)
      Wicaksono Dimas Prasetianto、Washio Jumpei、Abiko Yuki、Domon Hitomi、Takahashi Nobuhiro
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 86 Issue: 20 Pages: 1-9

    • DOI

      10.1128/aem.01255-20

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitrite-producing oral microbiome in adults and children2020

    • Author(s)
      Sato-Suzuki Y, Washio J, Wicaksono DP, Sato T, Fukumoto S, Takahashi N
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 16652-16652

    • DOI

      10.1038/s41598-020-73479-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electrochemical evaluation of the hydrogen peroxide- and fluoride-induced corrosive property and its recovery on the titanium surface2020

    • Author(s)
      Furiya-Sato S, Fukushima A, Mayanagi G, Sasaki K, Takahashi N
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 64 Issue: 3 Pages: 307-312

    • DOI

      10.1016/j.jpor.2019.09.002

    • NAID

      130007885745

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrated hypothesis of dental caries and periodontal diseases2020

    • Author(s)
      Nyvad B, Takahashi N
    • Journal Title

      Journal of Oral Microbiology

      Volume: 12 Issue: 1 Pages: 1710953-1710953

    • DOI

      10.1080/20002297.2019.1710953

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <b>Exhaled acetone and isoprene in perioperative lung cancer patients under intensive oral care: possible indicators of inflammatory responses and metabolic </b><b>changes </b>2019

    • Author(s)
      10.1016/j.jdent.2018.12.017
    • Journal Title

      Biomedical Research

      Volume: 40 Issue: 1 Pages: 29-36

    • DOI

      10.2220/biomedres.40.29

    • NAID

      130007603165

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2019-02-01
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic property of acetaldehyde production from ethanol and glucose by oral Streptococcus and Neisseria2019

    • Author(s)
      Tagaino R, Washio J, Abiko Y, Tanda N, Sasaki K, Takahashi N
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10446-10446

    • DOI

      10.1038/s41598-019-46790-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study2019

    • Author(s)
      Tanda Naoko、Washio Jumpei、Kamei Takashi、Akazawa Kohei、Takahashi Nobuhiro、Koseki Takeyoshi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 249 Issue: 1 Pages: 75-83

    • DOI

      10.1620/tjem.249.75

    • NAID

      130007719396

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sodium fluoride and silver diamine fluoride-coated tooth surfaces inhibit bacterial acid production at the bacteria/tooth interface.2019

    • Author(s)
      Ishiguro T, Mayanagi G, Azumi M, Otani H, Fukushima A, Sasaki K, Takahashi N
    • Journal Title

      J Dent.

      Volume: 印刷中 Pages: 30006-5

    • DOI

      10.1016/j.jdent.2018.12.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microbiological Deterioration of Dental Materials2018

    • Author(s)
      Takahashi N
    • Journal Title

      Journal of the Japan Society of Powder and Powder Metallurgy

      Volume: 65 Issue: 8 Pages: 489-494

    • DOI

      10.2497/jjspm.65.489

    • NAID

      130007467972

    • ISSN
      0532-8799, 1880-9014
    • Year and Date
      2018-08-15
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory effect of resin composite containing S-PRG filler on Streptococcus mutans glucose metabolism2018

    • Author(s)
      Kitagawa Haruaki、Miki-Oka Saeki、Mayanagi Gen、Abiko Yuki、Takahashi Nobuhiro、Imazato Satoshi
    • Journal Title

      J Dent.

      Volume: 70 Pages: 92-96

    • DOI

      10.1016/j.jdent.2017.12.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] SHOKU-gaku: Transdisciplinary Science of Eating, Food, and Nutrition2022

    • Author(s)
      Nobuhiro Takahashi
    • Organizer
      The 9th International Symposium for Interface Oral Health Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 根面う蝕モデル酸による根面内在性タンパク分解酵素の活性化 (Root caries model: Acid-induced activation of endogenous proteases embedded in root surfaces)2021

    • Author(s)
      櫻井 泉, 真柳 弦, 山田 聡, 高橋 信博
    • Organizer
      第63回歯科基礎医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 口腔Neisseria属による亜硝酸産生活性と環境因子による影響(The Nitrite producing activity of oral Neisseria and the effect of environmental factors)2021

    • Author(s)
      鷲尾 純平, 江副 和子, 佐藤 聡子, 安彦 友希, 小峰 英也, 柴田 怜, 田花 航平, 毛 雪竹, 高橋 信博
    • Organizer
      第63回歯科基礎医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 小児齲蝕の発症機序と生物学的要因2021

    • Author(s)
      高橋信博
    • Organizer
      第70回日本口腔衛生学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Oral Microbiome in Health and Diseases2021

    • Author(s)
      Nobuhiro Takahashi
    • Organizer
      Zhejiang University International Workshop
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「食学」とは2021

    • Author(s)
      髙橋信博
    • Organizer
      「革新的食学拠点」シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 口腔と全身の健康に関わる口腔バイオフィルムの代謝機能2021

    • Author(s)
      髙橋信博、鷲尾純平
    • Organizer
      第94回日本細菌学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Oral microbiome metabolism in oral and systemic health/disease2021

    • Author(s)
      Takahashi N
    • Organizer
      Kaohsiung Medical University (KMU) Research Day
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 『食学拠点の形成』の概要2020

    • Author(s)
      高橋信博
    • Organizer
      『食学拠点の形成』キックオフシンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 「口腔マイクロバイオームの細菌叢・代謝解析を基盤とした「食からのヘルスプロモーション」」2020

    • Author(s)
      鷲尾純平、互野亮、真柳弦、安彦友希、江副和子、Dimas Prasetianto Wicaksono、韓思理、大竹知菜、柳田保子、髙橋信博
    • Organizer
      『食学拠点の形成』キックオフシンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Periodontitis-associated bacterial culture supernatants inhibit the glucose metabolic activity of host cells2020

    • Author(s)
      Otani H, Washio J, Yamada S and Takahashi N
    • Organizer
      International Joint Symposium 2020 ( The 15th International Workshop on Biomaterials in Interface Science / The 11th Symposium on Innovative Dental-Engineering Alliance (IDEA)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of oral bacterial metabolism in oral health and diseases- Importance of analyzing bacterial metabolic activity2020

    • Author(s)
      Washio J, Takahashi N
    • Organizer
      The 2nd International Cooperation Symposium
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Metabolism of Oral Microbiome: From Its Fundamentals to the Latest Metabolome Analysis2020

    • Author(s)
      Takahashi N
    • Organizer
      Airlangga University STOVIT online series
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] EGCG inhibits acid production and promotes aggregation of Streptococcus mutans2020

    • Author(s)
      Han S
    • Organizer
      2020FJMU-HKU-TU International Online Symposium on Oral Health Sciences
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples2020

    • Author(s)
      Wakui A, Sano H, Kawachi M, Masuda N, Maruyama S, Washio J, Abiko Y, Mayanagi G, Yamaki K, Takahashi N, Okada Y, Sato T
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] The antimicrobial properties of green tea-derived epigallocatechin gallate on Streptococcus mutans2020

    • Author(s)
      Han S, Abiko Y, Washio J, Luo Y, Zhang L, Takahashi N
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Effect of nitrate (NO3-) and nitrite (NO2-) on the growth and NO2- producing activity of oral Veillonella species2020

    • Author(s)
      Wicaksono D. P., Washio J, Takahashi N
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 口腔内環境モニタリングに向けた全固体イオン選択電極センサアレイの開発と多変量解析アルゴリズムの検討2020

    • Author(s)
      大久保信吾、石原昇、山田哲也、栁田保子、真柳弦、鷲尾純平、高橋信博
    • Organizer
      日本化学会第15回バイオ関連化学シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Metformin inhibits oral cancer cell growth by altering glucose metabolism2020

    • Author(s)
      Liu S., Washio J., Takahashi N
    • Organizer
      The 68th Annual meeting of Japanese Association for Dental Research
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of oxygen concentration on glucose metabolism of cancer cells2020

    • Author(s)
      Shinohara Y, Washio J, Kobayashi Y, Abiko Y, Sasaki K, Takahashi N
    • Organizer
      The 98h IADR General Session & Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metformin Influenced Glucose Metabolic Activity of Cancer Cells2020

    • Author(s)
      Kobayashi Y, Washio J, Shinohara Y, Takahshi N
    • Organizer
      The 98h IADR General Session & Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metabolomics of Oral Microbiome2019

    • Author(s)
      Washio J, Abiko Y, Dimas Prasetianto Wicaksono, Yamamoto Y, Takahashi N
    • Organizer
      4th Asia Pacific Regional Congress of the International Association for Dental Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Involvement of oral bacteria -Importance of analyzing bacterial metabolic activity-2019

    • Author(s)
      Washio J, Mayanagi G, Abiko Y, Yanagida Y, Takahashi N
    • Organizer
      第4回生体医歯工学共同研究拠点国際シンポジウム
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The effect of heating on the glucose-based acid producing activity of cancer cells and normal cell2019

    • Author(s)
      Kobayashi Y, Washio J, Shinohara Y and Takahashi N
    • Organizer
      The 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-4)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔内細菌による糖・エタノール由来のアセトアルデヒド産生と口腔環境2019

    • Author(s)
      互野 亮,鷲尾純平,安彦友希,丹田奈緒子,佐々木啓一,髙橋信博
    • Organizer
      第8回口腔保健用機能性食品研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] The Role of Nitrate in Prevention of Oral Diseases by Supporting The Growth and Nitrite Production of Oral Veillonella2019

    • Author(s)
      Dimas Prasetianto Wicaksono, Jumpei Washio, Nobuhiro Takahashi
    • Organizer
      第8回口腔保健用機能性食品研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔細菌の酸産生抑制作用に着目した天然素材の探索2019

    • Author(s)
      北郡 秀晃, 鷲尾 純平, 安彦 友希, 髙橋 信博
    • Organizer
      第8回口腔保健用機能性食品研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 哺乳瓶用乳首(ニプル)を通して乳児用飲料を飲んだ際の,口腔からの逆流について2019

    • Author(s)
      涌井杏奈,佐野拓人,河内美帆,高橋彩朱伽,加藤理都,鷲尾純平,安彦友希,石黒和子,真柳 弦,高橋信博,佐藤拓一
    • Organizer
      第8回口腔保健用機能性食品研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 非破壊的超高感度細胞内ATP及びNADH計測マイクロデバイスの開発2018

    • Author(s)
      鷲尾純平、真柳弦、髙橋信博、柳田保子
    • Organizer
      東京工業大学 科学技術創成研究院 未来産業技術研究所-東北大学大学院歯学研究科 包括的研究協力協定にかかる連携シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] The oral microbiome as an ecosystem -Oral Microbiome Metabolism in Health and Disease-2018

    • Author(s)
      Takahashi N
    • Organizer
      The 5th Joint Scientific Meeting in Dentistry (JSMiD)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「生きている」を測る技術-リアルタイム代謝測定法が拓く生物学-2018

    • Author(s)
      高橋信博
    • Organizer
      東京工業大学 科学技術創成研究院 未来産業技術研究所-東北大学大学院歯学研究科 包括的研究協力協定にかかる連携シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] A novel method to screen and isolate nitrite-producing bacteria from the oral cavity2018

    • Author(s)
      Washio J, Suzuki Y, Sato T, Akiba M, Igarashi A, Kimura S, Tezuka S, Nakazato K and Takahashi N
    • Organizer
      International Symposium for Multimodal research and Education in IOHS-Liaison 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrochemical evaluation of the hydrogen peroxide-and fluoride-induced corrosive property and its recovery on the titanium surface.2018

    • Author(s)
      Sato S, Fukushima A, Mayanagi G, Sasaki K, Takahashi N
    • Organizer
      International Symposium for Multimodal research and Education in IOHS-Liaison 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acetaldehyde production by oral Streptococcus and Neisseria depending on oral environmental factors2018

    • Author(s)
      Tagaino R, Washio J, Abiko Y, Tanda N, Sasaki K and Takahashi N
    • Organizer
      International Symposium for Multimodal research and Education in IOHS-Liaison 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples2018

    • Author(s)
      Wakui A, Sano H, Aihara H, Kawachi M, Takahashi A, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
    • Organizer
      JADR2018/ 66th Japanese Division Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anti-acidogenic Effects of Licorice Extracts on Oral Biofilm Bacteria.2018

    • Author(s)
      Kitagori H, Washio J, Abiko Y, Tagaino R, Takahashi N
    • Organizer
      The 96h IADR General Session & Exhibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dental caries-associated glucose metabolism of oral Bifidobacterium.2018

    • Author(s)
      Abiko Y, Sugahara A, Murakami K, Kawashima J, Takahashi N
    • Organizer
      The 13th International Workshop on Biomaterials in Interface Science Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔細菌は弱アルカリ性好気環境で高いアセトアルデヒド産生を示す2018

    • Author(s)
      互野 亮, 鷲尾 純平, 丹田 奈緒子, 佐々木 啓一, 高橋 信博
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 環境中の硝酸塩による口腔Veillonella属の亜硝酸産生能の増加2018

    • Author(s)
      Dimas Prasetianto Wicaksono, 鷲尾 純平, 高橋 信博
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ニプルを通して飲んだ際の、ベビー飲料内への口腔細菌の流入2018

    • Author(s)
      相原 瞳、涌井杏奈、佐野拓人、河内美帆、鷲尾純平、安彦友希、真柳 弦、 八巻恵子、高橋信博、佐藤拓一
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 健康長寿を育む歯学教育コンソーシアム 東北大学の取り組み (第4報)2018

    • Author(s)
      真柳弦、高橋 信博、笹野 泰之、福本 敏、服部 佳功、佐々木 啓一
    • Organizer
      第37回日本歯科医学教育学会総会および学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] プラークのもつ硝酸還元活性と亜硝酸還元活性2018

    • Author(s)
      山本 祐慈, 清水 弘一, 五十嵐 公英, 鷲尾 純平, 高橋 信博
    • Organizer
      第67回 日本口腔衛生学会総会
    • Related Report
      2018 Research-status Report
  • [Book] 一般社団法人 全国歯科衛生士教育協議会(監修)「最新歯科衛生士教本用語集ポケット版」2019

    • Author(s)
      高橋信博
    • Total Pages
      10
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Book] 口腔生化学第6版2018

    • Author(s)
      高橋信博
    • Total Pages
      64
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report
  • [Book] 歯科衛生士国家試験問題研究会(編)「歯科衛生士国家試験予想問題集第2版-新出題基準準拠-」2018

    • Author(s)
      高橋信博
    • Total Pages
      10
    • Publisher
      医歯薬出版
    • Related Report
      2018 Research-status Report

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Published: 2018-07-25   Modified: 2023-01-30  

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