Do Bacteria Cause Cancer? Elucidation of "cell-microbiome interaction" using metabolism as an indicator
| Project/Area Number |
18K19629
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 57:Oral science and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鷲尾 純平 東北大学, 歯学研究科, 講師 (20400260)
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| Project Period (FY) |
2018-06-29 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 細胞代謝 / 代謝阻害 / Porphyromonas gingivalis / Gingipain / ジンジバリス菌 / ジンジパイン / ベイヨネラ菌 / 有機酸 / がん細胞 / リアルタイム代謝測定 / pHスタット / 酸素分圧可変チャンバー / 口腔がん / がん化 / 代謝 / レンサ球菌 / フゾバクテリウム |
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| Outline of Final Research Achievements |
It is becoming clear that bacteria are involved in the canceration of cells. Therefore, in this study, we examined the effect of bacteria on cells using metabolism as an indicator using "real-time metabolism monitoring system" that we developed. As a result, the following were clarified. It was found that (1) Porphromonas gingivalis (Pg), which is the most representative periodontal disease-associated bacterium among oral bacteria, suppresses cellular glucose metabolism, (2) the cell glucose metabolism inhibitor is present in the culture supernatant of Pg, and (3) it is not a Pg-specific proteolytic enzyme gingipain but a completely different protein.
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| Academic Significance and Societal Importance of the Research Achievements |
細菌が細胞のがん化に関わることが明らかになりつつある中、とくに口腔上皮は口腔細菌に常に触れており、その影響は不可避である。生命史の大部分において細胞と細菌は共存してきたが、研究は別々に進められてきた。細胞と細菌のインタラクションの新たな生物学が黎明期を迎える今、両者が共存する口腔を対象とする研究はその最前線となる。本研究で見出された細胞糖代謝をダイレクトに阻害するタンパク質の存在は、細胞と細菌のダイレクトなインタラクションの実例となるとともに、細菌による（がん）細胞コントロールの概念に新たな視点をもたらすものと考えられる。
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Report
(5 results)
Research Products
(72 results)
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[Journal Article] Bacterial amounts and compositions in liquid baby formula and a baby drink consumed with an artificial nipple.2021
Author(s)
Wakui A, Sano H, Kawachi M, Aida A, Takenaka Y, Yonezawa A, Nakahata N, Moriyama S, Nishikata M, Washio J, Abiko Y, Mayanagi G, Yamaki K, Sakashita R, Tanaka K, Takahashi N, Sato T
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Journal Title
J Oral Biosci.
Volume: 印刷中
Issue: 2
Pages: 161-168
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Profiling of microbiota at the mouth of bottles and in remaining tea after drinking directly from plastic bottles of tea2021
Author(s)
Wakui A*, Sano H*, Hirabuki Y*, Kawachi M, Aida A, Washio J, Abiko Y, Mayanagi G, Yamaki K, Tanaka K, Takahashi N, Sato T
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Journal Title
Dentistry Journal
Volume: 9
Issue: 6
Pages: 58-58
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples2020
Author(s)
Wakui A, Sano H, Kawachi M, Masuda N, Maruyama S, Washio J, Abiko Y, Mayanagi G, Yamaki K, Takahashi N, Okada Y, Sato T
Organizer
第62回歯科基礎医学会学術大会
Related Report
Invited
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[Presentation] Metabolomics of Oral Microbiome2019
Author(s)
Washio J, Abiko Y, Dimas Prasetianto Wicaksono, Yamamoto Y, Takahashi N
Organizer
4th Asia Pacific Regional Congress of the International Association for Dental Research
Related Report
Int'l Joint Research / Invited
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[Presentation] Profiling of Microbiota of Baby-Drinks after Drinking with Artificial Nipples2018
Author(s)
Wakui A, Sano H, Aihara H, Kawachi M, Takahashi A, Washio J, Abiko Y, Mayanagi G, Ishiguro K, Yamaki K, Takahashi N, Sato T
Organizer
JADR2018/ 66th Japanese Division Meeting 2018
Related Report
Int'l Joint Research
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